Designing and Fabrication of Nano-Hydroxyapatite and Curcumin-Loaded Chitosan/PVA Nanofibrous Mats for Potential Use as Wound Dressing Biomaterials
Chitosan/polyvinyl alcohol nanofibrous mats loaded with nano-hydroxyapatite and/or curcumin are successfully fabricated by the electrospinning method for the first time. Nano-hydroxyapatite is prepared by the co-precipitation method. The XRD pattern of calcined powder at 700 °C for 2 h reveals the p...
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2025-01-01
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| Series: | Nanomaterials |
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| author | Amira M. EL-Rafei Giorgia Maurizii Annalisa Aluigi Giovanna Sotgiu Marianna Barbalinardo Tamara Posati |
| author_facet | Amira M. EL-Rafei Giorgia Maurizii Annalisa Aluigi Giovanna Sotgiu Marianna Barbalinardo Tamara Posati |
| author_sort | Amira M. EL-Rafei |
| collection | DOAJ |
| description | Chitosan/polyvinyl alcohol nanofibrous mats loaded with nano-hydroxyapatite and/or curcumin are successfully fabricated by the electrospinning method for the first time. Nano-hydroxyapatite is prepared by the co-precipitation method. The XRD pattern of calcined powder at 700 °C for 2 h reveals the presence of hydroxyapatite as a sole phase. FT-IR confirms its purity. The morphology of the hydroxyapatite is studied by HR-TEM. Nano-hydroxyapatite and curcumin are added at 5 wt% with respect to the polymer weight. XRD, FE-SEM, FT-IR, and HR-TEM are used to characterize the fabricated nanofibrous mats. The results confirm the successful loading of nano-hydroxyapatite and curcumin within the fabricated mats. The in vitro antimicrobial results show that most of mats have significant antimicrobial effects against <i>E. coli</i> and <i>S. aureus</i>. The fabricated matd are biocompatible with fibroblasts and the presence of curcumin increases cell viability. Curcumin release from both CS/PVA/Cur and CS/PVA/HA/Cur nanofiber mats principally follows the Korsmeyer–Peppas and Peppas–Salhin models. |
| format | Article |
| id | doaj-art-38b253aff21745ddaa384f5a12869577 |
| institution | Kabale University |
| issn | 2079-4991 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
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| series | Nanomaterials |
| spelling | doaj-art-38b253aff21745ddaa384f5a128695772025-01-24T13:44:04ZengMDPI AGNanomaterials2079-49912025-01-011528210.3390/nano15020082Designing and Fabrication of Nano-Hydroxyapatite and Curcumin-Loaded Chitosan/PVA Nanofibrous Mats for Potential Use as Wound Dressing BiomaterialsAmira M. EL-Rafei0Giorgia Maurizii1Annalisa Aluigi2Giovanna Sotgiu3Marianna Barbalinardo4Tamara Posati5Refractories, Ceramics and Building Materials Department, National Research Centre, 33 EL Bohouth St., Dokki, Giza P.O. Box 12622, EgyptDepartment of Biomolecular Sciences, University of Urbino Carlo Bo, Piazza del Rinascimento, 6, 61029 Urbino, ItalyDepartment of Biomolecular Sciences, University of Urbino Carlo Bo, Piazza del Rinascimento, 6, 61029 Urbino, ItalyConsiglio Nazionale delle Ricerche (CNR), Istituto per la Sintesi Organica e Fotoreattività (ISOF), Via Piero Gobetti, 101, 40129 Bologna, ItalyConsiglio Nazionale delle Ricerche (CNR), Istituto per la Sintesi Organica e Fotoreattività (ISOF), Via Piero Gobetti, 101, 40129 Bologna, ItalyConsiglio Nazionale delle Ricerche (CNR), Istituto per la Sintesi Organica e Fotoreattività (ISOF), Via Piero Gobetti, 101, 40129 Bologna, ItalyChitosan/polyvinyl alcohol nanofibrous mats loaded with nano-hydroxyapatite and/or curcumin are successfully fabricated by the electrospinning method for the first time. Nano-hydroxyapatite is prepared by the co-precipitation method. The XRD pattern of calcined powder at 700 °C for 2 h reveals the presence of hydroxyapatite as a sole phase. FT-IR confirms its purity. The morphology of the hydroxyapatite is studied by HR-TEM. Nano-hydroxyapatite and curcumin are added at 5 wt% with respect to the polymer weight. XRD, FE-SEM, FT-IR, and HR-TEM are used to characterize the fabricated nanofibrous mats. The results confirm the successful loading of nano-hydroxyapatite and curcumin within the fabricated mats. The in vitro antimicrobial results show that most of mats have significant antimicrobial effects against <i>E. coli</i> and <i>S. aureus</i>. The fabricated matd are biocompatible with fibroblasts and the presence of curcumin increases cell viability. Curcumin release from both CS/PVA/Cur and CS/PVA/HA/Cur nanofiber mats principally follows the Korsmeyer–Peppas and Peppas–Salhin models.https://www.mdpi.com/2079-4991/15/2/82chitosanpolyvinyl alcoholnano-hydroxyapatitecurcuminelectrospinningdrug delivery |
| spellingShingle | Amira M. EL-Rafei Giorgia Maurizii Annalisa Aluigi Giovanna Sotgiu Marianna Barbalinardo Tamara Posati Designing and Fabrication of Nano-Hydroxyapatite and Curcumin-Loaded Chitosan/PVA Nanofibrous Mats for Potential Use as Wound Dressing Biomaterials Nanomaterials chitosan polyvinyl alcohol nano-hydroxyapatite curcumin electrospinning drug delivery |
| title | Designing and Fabrication of Nano-Hydroxyapatite and Curcumin-Loaded Chitosan/PVA Nanofibrous Mats for Potential Use as Wound Dressing Biomaterials |
| title_full | Designing and Fabrication of Nano-Hydroxyapatite and Curcumin-Loaded Chitosan/PVA Nanofibrous Mats for Potential Use as Wound Dressing Biomaterials |
| title_fullStr | Designing and Fabrication of Nano-Hydroxyapatite and Curcumin-Loaded Chitosan/PVA Nanofibrous Mats for Potential Use as Wound Dressing Biomaterials |
| title_full_unstemmed | Designing and Fabrication of Nano-Hydroxyapatite and Curcumin-Loaded Chitosan/PVA Nanofibrous Mats for Potential Use as Wound Dressing Biomaterials |
| title_short | Designing and Fabrication of Nano-Hydroxyapatite and Curcumin-Loaded Chitosan/PVA Nanofibrous Mats for Potential Use as Wound Dressing Biomaterials |
| title_sort | designing and fabrication of nano hydroxyapatite and curcumin loaded chitosan pva nanofibrous mats for potential use as wound dressing biomaterials |
| topic | chitosan polyvinyl alcohol nano-hydroxyapatite curcumin electrospinning drug delivery |
| url | https://www.mdpi.com/2079-4991/15/2/82 |
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