Designing and Fabrication of Nano-Hydroxyapatite and Curcumin-Loaded Chitosan/PVA Nanofibrous Mats for Potential Use as Wound Dressing Biomaterials
Chitosan/polyvinyl alcohol nanofibrous mats loaded with nano-hydroxyapatite and/or curcumin are successfully fabricated by the electrospinning method for the first time. Nano-hydroxyapatite is prepared by the co-precipitation method. The XRD pattern of calcined powder at 700 °C for 2 h reveals the p...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-01-01
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| Series: | Nanomaterials |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-4991/15/2/82 |
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| Summary: | Chitosan/polyvinyl alcohol nanofibrous mats loaded with nano-hydroxyapatite and/or curcumin are successfully fabricated by the electrospinning method for the first time. Nano-hydroxyapatite is prepared by the co-precipitation method. The XRD pattern of calcined powder at 700 °C for 2 h reveals the presence of hydroxyapatite as a sole phase. FT-IR confirms its purity. The morphology of the hydroxyapatite is studied by HR-TEM. Nano-hydroxyapatite and curcumin are added at 5 wt% with respect to the polymer weight. XRD, FE-SEM, FT-IR, and HR-TEM are used to characterize the fabricated nanofibrous mats. The results confirm the successful loading of nano-hydroxyapatite and curcumin within the fabricated mats. The in vitro antimicrobial results show that most of mats have significant antimicrobial effects against <i>E. coli</i> and <i>S. aureus</i>. The fabricated matd are biocompatible with fibroblasts and the presence of curcumin increases cell viability. Curcumin release from both CS/PVA/Cur and CS/PVA/HA/Cur nanofiber mats principally follows the Korsmeyer–Peppas and Peppas–Salhin models. |
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| ISSN: | 2079-4991 |