The Role of Prolactin as a Disease Activity Indicator in Some Rheumatic Diseases
Background: Autoimmune rheumatic diseases, including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and scleroderma, predominantly affect women and are characterized by systemic inflammation, leading to organ failure. Prolactin (PRL), a hormone produced by the pituitary gland and lym...
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South Valley University, Faculty of Medicine
2025-07-01
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| Series: | SVU - International Journal of Medical Sciences |
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| Online Access: | https://svuijm.journals.ekb.eg/article_382169.html |
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| author | Mohamed Ismail Abdelkarem HM Fayed Wael Abd El-Mohsen Abady Eman Abulhagag Mohammed Mahmoud |
| author_facet | Mohamed Ismail Abdelkarem HM Fayed Wael Abd El-Mohsen Abady Eman Abulhagag Mohammed Mahmoud |
| author_sort | Mohamed Ismail Abdelkarem |
| collection | DOAJ |
| description | Background: Autoimmune rheumatic diseases, including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and scleroderma, predominantly affect women and are characterized by systemic inflammation, leading to organ failure. Prolactin (PRL), a hormone produced by the pituitary gland and lymphocytes, significantly affects immune regulation and is implicated in the pathophysiology of these diseases.
Objectives: This study aimed to evaluate the relationship between PRL levels and disease activity in RA, SLE, and scleroderma.
Patients and methods: A cross-sectional case-control study involved 150 premenopausal women (50 with RA, 30 with SLE, and 20 with scleroderma) and 50 age-matched healthy controls. Clinical disease activity assessments (DAS28 for RA, SLEDAI for SLE, and MRSS for scleroderma) and laboratory estimation of serum PRL level were conducted.
Results: The mean PRL levels in RA (26.17 ng/ml), SLE (25.23 ng/ml), and scleroderma (32.07 ng/ml) were significantly higher than controls (15.48 ng/ml) (P < 0.001). 42% of RA patients, 30% of SLE patients, and 50% of scleroderma patients had elevated PRL levels. Hyperprolacinemia is correlated with disease activity (DAS28 (r = 0.493, p = 0.0001), SLEDAI (r = 0.546, p = 0.002), and MRSS (r = 0.893, p = 0.0001), respectively).
Conclusion: Serum PRL levels were significantly elevated in RA, SLE, and scleroderma, which is consistent with disease activity scores. Regular monitoring may be necessary because of the potential of PRL to function as a marker of disease activity. The therapeutic potential of dopamine agonists in autoimmune diseases warrants further investigation, as they have the potential to reduce flare-ups and organ involvement. |
| format | Article |
| id | doaj-art-38ae996a574a4da2b79832f1d9c6257d |
| institution | Kabale University |
| issn | 2735-427X 2636-3402 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | South Valley University, Faculty of Medicine |
| record_format | Article |
| series | SVU - International Journal of Medical Sciences |
| spelling | doaj-art-38ae996a574a4da2b79832f1d9c6257d2025-02-06T09:45:18ZengSouth Valley University, Faculty of MedicineSVU - International Journal of Medical Sciences2735-427X2636-34022025-07-0172529544https://doi.org/10.21608/svuijm.2024.299939.1904The Role of Prolactin as a Disease Activity Indicator in Some Rheumatic DiseasesMohamed Ismail Abdelkarem 0HM Fayed 1 Wael Abd El-Mohsen Abady2 Eman Abulhagag Mohammed Mahmoud 3Rheumatology and Rehabilitation Department, Faculty of Medicine, Al-Azhar University (Assiut Branch), Assuit, Egypt.Clinical Pathology Department, Faculty of Medicine, South Valley University, Qena, Egypt Physical Medicine, Rheumatology and Rehabilitation Department, Faculty of Medicine, South Valley University, Qena, Egypt. Physical Medicine, Rheumatology and Rehabilitation Department, Faculty of Medicine, South Valley University, Qena, Egypt.Background: Autoimmune rheumatic diseases, including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and scleroderma, predominantly affect women and are characterized by systemic inflammation, leading to organ failure. Prolactin (PRL), a hormone produced by the pituitary gland and lymphocytes, significantly affects immune regulation and is implicated in the pathophysiology of these diseases. Objectives: This study aimed to evaluate the relationship between PRL levels and disease activity in RA, SLE, and scleroderma. Patients and methods: A cross-sectional case-control study involved 150 premenopausal women (50 with RA, 30 with SLE, and 20 with scleroderma) and 50 age-matched healthy controls. Clinical disease activity assessments (DAS28 for RA, SLEDAI for SLE, and MRSS for scleroderma) and laboratory estimation of serum PRL level were conducted. Results: The mean PRL levels in RA (26.17 ng/ml), SLE (25.23 ng/ml), and scleroderma (32.07 ng/ml) were significantly higher than controls (15.48 ng/ml) (P < 0.001). 42% of RA patients, 30% of SLE patients, and 50% of scleroderma patients had elevated PRL levels. Hyperprolacinemia is correlated with disease activity (DAS28 (r = 0.493, p = 0.0001), SLEDAI (r = 0.546, p = 0.002), and MRSS (r = 0.893, p = 0.0001), respectively). Conclusion: Serum PRL levels were significantly elevated in RA, SLE, and scleroderma, which is consistent with disease activity scores. Regular monitoring may be necessary because of the potential of PRL to function as a marker of disease activity. The therapeutic potential of dopamine agonists in autoimmune diseases warrants further investigation, as they have the potential to reduce flare-ups and organ involvement.https://svuijm.journals.ekb.eg/article_382169.htmlrheumatoid arthritis systemic lupus erythematosussystemic sclerosis das28 sledai |
| spellingShingle | Mohamed Ismail Abdelkarem HM Fayed Wael Abd El-Mohsen Abady Eman Abulhagag Mohammed Mahmoud The Role of Prolactin as a Disease Activity Indicator in Some Rheumatic Diseases SVU - International Journal of Medical Sciences rheumatoid arthritis systemic lupus erythematosus systemic sclerosis das28 sledai |
| title | The Role of Prolactin as a Disease Activity Indicator in Some Rheumatic Diseases |
| title_full | The Role of Prolactin as a Disease Activity Indicator in Some Rheumatic Diseases |
| title_fullStr | The Role of Prolactin as a Disease Activity Indicator in Some Rheumatic Diseases |
| title_full_unstemmed | The Role of Prolactin as a Disease Activity Indicator in Some Rheumatic Diseases |
| title_short | The Role of Prolactin as a Disease Activity Indicator in Some Rheumatic Diseases |
| title_sort | role of prolactin as a disease activity indicator in some rheumatic diseases |
| topic | rheumatoid arthritis systemic lupus erythematosus systemic sclerosis das28 sledai |
| url | https://svuijm.journals.ekb.eg/article_382169.html |
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