Prevalence of major depressive disorder in adult patients with alcohol use disorder admitted in the psychiatric ward at the Jigme Dorji Wangchuck National Referral Hospital, Thimphu, Bhutan
Introduction The increasing prevalence of major depressive disorder (MDD) in alcohol use disorder (AUD) is associated with detrimental consequences, affecting the course and outcome of each disorder. The objective of this crosssectional study was to study the prevalence and severity of MDD and assoc...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
European Publishing
2023-05-01
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| Series: | Population Medicine |
| Subjects: | |
| Online Access: | https://www.populationmedicine.eu/Prevalence-of-major-depressive-disorder-in-adult-patients-with-alcohol-use-disorder,166187,0,2.html |
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| Summary: | Introduction
The increasing prevalence of major depressive
disorder (MDD) in alcohol use disorder (AUD) is associated
with detrimental consequences, affecting the course and
outcome of each disorder. The objective of this crosssectional
study was to study the prevalence and severity of
MDD and associated risk factors in Bhutanese adult patients
with AUD admitted to the psychiatric ward, YJigme Dorji
Wangchuck National Referral Hospital, from March 2020 to
February 2021.
Methods
All patients with AUD presenting for alcohol
detoxification for the first time with MDD as the only
associated psychiatric comorbidity were administered
a sociodemographic questionnaire and Patient Health
Questionnaire-9 (PHQ-9). Multivariate binary logistic
regression was carried out to determine factors associated
with depression using two models. All independent variables
were computed for multivariate logistic regression in Model
1. For Model 2, variables with p<0.2 from Model 1 were
included. Akaike information criterion (AIC) score was used
to construct our final multivariable model.
Results
The overall prevalence of major depression (PHQ-
9 score ≥10) among the participants was 38% (59/155).
Participants with mild depression (PHQ-9 score = 5–9) were
excluded. Participants with family history of alcohol and
substance use disorder demonstrated higher prevalence
of depression (p=0.03). In the multivariate binary logistic
regression, female participants (AOR=2.19; 95% CI: 1.01–
4.75) and respondents with family history of psychiatric
illness (AOR=4.63; 95% CI: 1.17–18.44) were more likely to
develop MDD.
Conclusions
This study demonstrated a high prevalence of
MDD in AUD patients. Female gender, having a positive family
history of psychiatric illness and a positive family history
of alcohol and drug use were associated with increased
likelihood of developing depression. Routine screening,
initiating appropriate treatment, referral and follow-up of
MDD in AUD patients may improve the prognosis of both the
disorders. |
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| ISSN: | 2654-1459 |