To Bind or to Let Loose: Effectiveness of Sodium Polystyrene Sulfonate in Decreasing Serum Potassium
Background. The use of sodium polystyrene sulfonate in decreasing serum potassium has recently been questioned due to the lack of documented effectiveness. Methods. A retrospective cohort analysis of all hospitalized patients who received sodium polystyrene sulfonate over four months was performed....
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Nephrology |
| Online Access: | http://dx.doi.org/10.1155/2012/940320 |
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| _version_ | 1832561759678889984 |
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| author | Shaifali Sandal Hatim Karachiwala John Noviasky Dongliang Wang William C. Elliott David F. Lehmann |
| author_facet | Shaifali Sandal Hatim Karachiwala John Noviasky Dongliang Wang William C. Elliott David F. Lehmann |
| author_sort | Shaifali Sandal |
| collection | DOAJ |
| description | Background. The use of sodium polystyrene sulfonate in decreasing serum potassium has recently been questioned due to the lack of documented effectiveness. Methods. A retrospective cohort analysis of all hospitalized patients who received sodium polystyrene sulfonate over four months was performed. The change in serum potassium was noted over a period of 24 hours. Patients who received any other form of potassium-altering drug or treatment were excluded. Results. The administration of sodium polystyrene sulfonate reduced serum potassium by 16.7% (P<0.001) as compared to the baseline serum potassium over a period of 24 hours. During this same time, no change in serum creatinine was identified (P=0.73). In addition, there was no correlation between potassium and creatinine change (r2 = 0.0004 and P=0.99). Patients with higher initial serum potassium (≥5.6 mEq/L) reduced their potassium concentration 4% more than those with initial serum potassium of <5.6 mEq/L; however, this reduction did not reach statistical significance (P=0.32). There was no significant difference in the effectiveness of 15 gm and 30 gm resin preparation (P=0.54). Thirteen deaths were noted in our cohort, of which one death was due to ischemic colitis. Conclusion. We conclude that sodium polystyrene sulfonate is effective in lowering serum potassium. |
| format | Article |
| id | doaj-art-389d5d12890441d7b8ea0dd925b00d91 |
| institution | Kabale University |
| issn | 2090-214X 2090-2158 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Nephrology |
| spelling | doaj-art-389d5d12890441d7b8ea0dd925b00d912025-02-03T01:24:19ZengWileyInternational Journal of Nephrology2090-214X2090-21582012-01-01201210.1155/2012/940320940320To Bind or to Let Loose: Effectiveness of Sodium Polystyrene Sulfonate in Decreasing Serum PotassiumShaifali Sandal0Hatim Karachiwala1John Noviasky2Dongliang Wang3William C. Elliott4David F. Lehmann5Division of Nephrology, University of Rochester Medical Center, 601 Elmwood Avenue, P.O. Box 675, Rochester, NY 14642, USADivision of Oncology, Dalhousie University, Room 457A, Bethune Building, 1276 South Park Street Halifax, Nova Scotia, B3H 2Y9, CanadaDepartment of Pharmacy, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USADepartments of Public Health and Preventive Medicine, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USADepartments of Public Health and Preventive Medicine, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USADepartment of Medicine, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USABackground. The use of sodium polystyrene sulfonate in decreasing serum potassium has recently been questioned due to the lack of documented effectiveness. Methods. A retrospective cohort analysis of all hospitalized patients who received sodium polystyrene sulfonate over four months was performed. The change in serum potassium was noted over a period of 24 hours. Patients who received any other form of potassium-altering drug or treatment were excluded. Results. The administration of sodium polystyrene sulfonate reduced serum potassium by 16.7% (P<0.001) as compared to the baseline serum potassium over a period of 24 hours. During this same time, no change in serum creatinine was identified (P=0.73). In addition, there was no correlation between potassium and creatinine change (r2 = 0.0004 and P=0.99). Patients with higher initial serum potassium (≥5.6 mEq/L) reduced their potassium concentration 4% more than those with initial serum potassium of <5.6 mEq/L; however, this reduction did not reach statistical significance (P=0.32). There was no significant difference in the effectiveness of 15 gm and 30 gm resin preparation (P=0.54). Thirteen deaths were noted in our cohort, of which one death was due to ischemic colitis. Conclusion. We conclude that sodium polystyrene sulfonate is effective in lowering serum potassium.http://dx.doi.org/10.1155/2012/940320 |
| spellingShingle | Shaifali Sandal Hatim Karachiwala John Noviasky Dongliang Wang William C. Elliott David F. Lehmann To Bind or to Let Loose: Effectiveness of Sodium Polystyrene Sulfonate in Decreasing Serum Potassium International Journal of Nephrology |
| title | To Bind or to Let Loose: Effectiveness of Sodium Polystyrene Sulfonate in Decreasing Serum Potassium |
| title_full | To Bind or to Let Loose: Effectiveness of Sodium Polystyrene Sulfonate in Decreasing Serum Potassium |
| title_fullStr | To Bind or to Let Loose: Effectiveness of Sodium Polystyrene Sulfonate in Decreasing Serum Potassium |
| title_full_unstemmed | To Bind or to Let Loose: Effectiveness of Sodium Polystyrene Sulfonate in Decreasing Serum Potassium |
| title_short | To Bind or to Let Loose: Effectiveness of Sodium Polystyrene Sulfonate in Decreasing Serum Potassium |
| title_sort | to bind or to let loose effectiveness of sodium polystyrene sulfonate in decreasing serum potassium |
| url | http://dx.doi.org/10.1155/2012/940320 |
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