Circadian Clock Gene Bmal1: A Molecular Bridge from AKI to CKD

Acute kidney injury (AKI) and chronic kidney disease (CKD) represent two frequently observed clinical conditions. AKI is characterized by an abrupt decrease in glomerular filtration rate (GFR), generally associated with elevated serum creatinine (sCr), blood urea nitrogen (BUN), and electrolyte imba...

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Main Authors: Songyuan Yang, Zehua Ye, Lijia Chen, Xiangjun Zhou, Wei Li, Fan Cheng
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Biomolecules
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Online Access:https://www.mdpi.com/2218-273X/15/1/77
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author Songyuan Yang
Zehua Ye
Lijia Chen
Xiangjun Zhou
Wei Li
Fan Cheng
author_facet Songyuan Yang
Zehua Ye
Lijia Chen
Xiangjun Zhou
Wei Li
Fan Cheng
author_sort Songyuan Yang
collection DOAJ
description Acute kidney injury (AKI) and chronic kidney disease (CKD) represent two frequently observed clinical conditions. AKI is characterized by an abrupt decrease in glomerular filtration rate (GFR), generally associated with elevated serum creatinine (sCr), blood urea nitrogen (BUN), and electrolyte imbalances. This condition usually persists for approximately a week, causing a transient reduction in kidney function. If these abnormalities continue beyond 90 days, the condition is redefined as chronic kidney disease (CKD) or may advance to end-stage renal disease (ESRD). Recent research increasingly indicates that maladaptive repair mechanisms after AKI significantly contribute to the development of CKD. Thus, implementing early interventions to halt the progression from AKI to CKD has the potential to markedly improve patient outcomes. Although considerable research has been conducted, the exact mechanisms linking AKI to CKD are complex, and effective treatments remain limited. Kidney function is influenced by circadian rhythms, with the circadian gene Bmal1 being vital in managing these cycles. Recent research indicates that Bmal1 is significantly involved in the progression of both AKI and CKD. In this study, we conducted a retrospective analysis of Bmal1’s role in AKI and CKD, reviewed recent research advancements, and investigated how Bmal1 influences the pathological mechanisms underlying the progression from AKI to CKD. Additionally, we highlighted gaps in the existing research and examined the potential of Bmal1 as a therapeutic target in kidney disease management. This work aims to provide meaningful insights for future studies on the role of the circadian gene Bmal1 in the transition from AKI to CKD, with the goal of identifying therapeutic approaches to mitigate kidney disease progression.
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spelling doaj-art-389d588b4fa8492cbf0d0f1c65fb7ca32025-01-24T13:25:05ZengMDPI AGBiomolecules2218-273X2025-01-011517710.3390/biom15010077Circadian Clock Gene Bmal1: A Molecular Bridge from AKI to CKDSongyuan Yang0Zehua Ye1Lijia Chen2Xiangjun Zhou3Wei Li4Fan Cheng5Department of Urology, Renmin Hospital of Wuhan University, Wuhan 430060, ChinaDepartment of Urology, Renmin Hospital of Wuhan University, Wuhan 430060, ChinaDepartment of Urology, Renmin Hospital of Wuhan University, Wuhan 430060, ChinaDepartment of Urology, Renmin Hospital of Wuhan University, Wuhan 430060, ChinaDepartment of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan 430060, ChinaDepartment of Urology, Renmin Hospital of Wuhan University, Wuhan 430060, ChinaAcute kidney injury (AKI) and chronic kidney disease (CKD) represent two frequently observed clinical conditions. AKI is characterized by an abrupt decrease in glomerular filtration rate (GFR), generally associated with elevated serum creatinine (sCr), blood urea nitrogen (BUN), and electrolyte imbalances. This condition usually persists for approximately a week, causing a transient reduction in kidney function. If these abnormalities continue beyond 90 days, the condition is redefined as chronic kidney disease (CKD) or may advance to end-stage renal disease (ESRD). Recent research increasingly indicates that maladaptive repair mechanisms after AKI significantly contribute to the development of CKD. Thus, implementing early interventions to halt the progression from AKI to CKD has the potential to markedly improve patient outcomes. Although considerable research has been conducted, the exact mechanisms linking AKI to CKD are complex, and effective treatments remain limited. Kidney function is influenced by circadian rhythms, with the circadian gene Bmal1 being vital in managing these cycles. Recent research indicates that Bmal1 is significantly involved in the progression of both AKI and CKD. In this study, we conducted a retrospective analysis of Bmal1’s role in AKI and CKD, reviewed recent research advancements, and investigated how Bmal1 influences the pathological mechanisms underlying the progression from AKI to CKD. Additionally, we highlighted gaps in the existing research and examined the potential of Bmal1 as a therapeutic target in kidney disease management. This work aims to provide meaningful insights for future studies on the role of the circadian gene Bmal1 in the transition from AKI to CKD, with the goal of identifying therapeutic approaches to mitigate kidney disease progression.https://www.mdpi.com/2218-273X/15/1/77circadian clockBmal1AKICKD
spellingShingle Songyuan Yang
Zehua Ye
Lijia Chen
Xiangjun Zhou
Wei Li
Fan Cheng
Circadian Clock Gene Bmal1: A Molecular Bridge from AKI to CKD
Biomolecules
circadian clock
Bmal1
AKI
CKD
title Circadian Clock Gene Bmal1: A Molecular Bridge from AKI to CKD
title_full Circadian Clock Gene Bmal1: A Molecular Bridge from AKI to CKD
title_fullStr Circadian Clock Gene Bmal1: A Molecular Bridge from AKI to CKD
title_full_unstemmed Circadian Clock Gene Bmal1: A Molecular Bridge from AKI to CKD
title_short Circadian Clock Gene Bmal1: A Molecular Bridge from AKI to CKD
title_sort circadian clock gene bmal1 a molecular bridge from aki to ckd
topic circadian clock
Bmal1
AKI
CKD
url https://www.mdpi.com/2218-273X/15/1/77
work_keys_str_mv AT songyuanyang circadianclockgenebmal1amolecularbridgefromakitockd
AT zehuaye circadianclockgenebmal1amolecularbridgefromakitockd
AT lijiachen circadianclockgenebmal1amolecularbridgefromakitockd
AT xiangjunzhou circadianclockgenebmal1amolecularbridgefromakitockd
AT weili circadianclockgenebmal1amolecularbridgefromakitockd
AT fancheng circadianclockgenebmal1amolecularbridgefromakitockd