The Mechanisms of Movement Control and Time Estimation in Cervical Dystonia Patients
Traditionally, the pathophysiology of cervical dystonia has been regarded mainly in relation to neurochemical abnormities in the basal ganglia. Recently, however, substantial evidence has emerged for cerebellar involvement. While the absence of neurological “cerebellar signs” in most dystonia patien...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2013/908741 |
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| author | Pavel Filip Ovidiu V. Lungu Daniel J. Shaw Tomas Kasparek Martin Bareš |
| author_facet | Pavel Filip Ovidiu V. Lungu Daniel J. Shaw Tomas Kasparek Martin Bareš |
| author_sort | Pavel Filip |
| collection | DOAJ |
| description | Traditionally, the pathophysiology of cervical dystonia has been regarded mainly in relation to neurochemical abnormities in the basal ganglia. Recently, however, substantial evidence has emerged for cerebellar involvement. While the absence of neurological “cerebellar signs” in most dystonia patients may be considered at least provoking, there are more subtle indications of cerebellar dysfunction in complex, demanding tasks. Specifically, given the role of the cerebellum in the neural representation of time, in the millisecond range, dysfunction to this structure is considered to be of greater importance than dysfunction of the basal ganglia. In the current study, we investigated the performance of cervical dystonia patients on a computer task known to engage the cerebellum, namely, the interception of a moving target with changing parameters (speed, acceleration, and angle) with a simple response (pushing a button). The cervical dystonia patients achieved significantly worse results than a sample of healthy controls. Our results suggest that the cervical dystonia patients are impaired at integrating incoming visual information with motor responses during the prediction of upcoming actions, an impairment we interpret as evidence of cerebellar dysfunction. |
| format | Article |
| id | doaj-art-389b16b8b1374646a5d79136a09a3fbe |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-389b16b8b1374646a5d79136a09a3fbe2025-02-03T05:54:16ZengWileyNeural Plasticity2090-59041687-54432013-01-01201310.1155/2013/908741908741The Mechanisms of Movement Control and Time Estimation in Cervical Dystonia PatientsPavel Filip0Ovidiu V. Lungu1Daniel J. Shaw2Tomas Kasparek3Martin Bareš4Central European Institute of Technology, CEITEC MU, Behavioral and Social Neuroscience Research Group, Masaryk University, 625 00 Brno, Czech RepublicDepartment of Psychiatry, University of Montréal, Montréal, QC, H3C 3T5, CanadaCentral European Institute of Technology, CEITEC MU, Behavioral and Social Neuroscience Research Group, Masaryk University, 625 00 Brno, Czech RepublicCentral European Institute of Technology, CEITEC MU, Behavioral and Social Neuroscience Research Group, Masaryk University, 625 00 Brno, Czech RepublicCentral European Institute of Technology, CEITEC MU, Behavioral and Social Neuroscience Research Group, Masaryk University, 625 00 Brno, Czech RepublicTraditionally, the pathophysiology of cervical dystonia has been regarded mainly in relation to neurochemical abnormities in the basal ganglia. Recently, however, substantial evidence has emerged for cerebellar involvement. While the absence of neurological “cerebellar signs” in most dystonia patients may be considered at least provoking, there are more subtle indications of cerebellar dysfunction in complex, demanding tasks. Specifically, given the role of the cerebellum in the neural representation of time, in the millisecond range, dysfunction to this structure is considered to be of greater importance than dysfunction of the basal ganglia. In the current study, we investigated the performance of cervical dystonia patients on a computer task known to engage the cerebellum, namely, the interception of a moving target with changing parameters (speed, acceleration, and angle) with a simple response (pushing a button). The cervical dystonia patients achieved significantly worse results than a sample of healthy controls. Our results suggest that the cervical dystonia patients are impaired at integrating incoming visual information with motor responses during the prediction of upcoming actions, an impairment we interpret as evidence of cerebellar dysfunction.http://dx.doi.org/10.1155/2013/908741 |
| spellingShingle | Pavel Filip Ovidiu V. Lungu Daniel J. Shaw Tomas Kasparek Martin Bareš The Mechanisms of Movement Control and Time Estimation in Cervical Dystonia Patients Neural Plasticity |
| title | The Mechanisms of Movement Control and Time Estimation in Cervical Dystonia Patients |
| title_full | The Mechanisms of Movement Control and Time Estimation in Cervical Dystonia Patients |
| title_fullStr | The Mechanisms of Movement Control and Time Estimation in Cervical Dystonia Patients |
| title_full_unstemmed | The Mechanisms of Movement Control and Time Estimation in Cervical Dystonia Patients |
| title_short | The Mechanisms of Movement Control and Time Estimation in Cervical Dystonia Patients |
| title_sort | mechanisms of movement control and time estimation in cervical dystonia patients |
| url | http://dx.doi.org/10.1155/2013/908741 |
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