Investigation of the Protective Effects of Taurine against Alloxan-Induced Diabetic Retinal Changes via Electroretinogram and Retinal Histology with New Zealand White Rabbits
The purpose of this study was to investigate the protective role of orally administered taurine against diabetic retinal changes via electroretinogram (ERG) and retinal histology on rabbits. Rabbits were randomly assigned into groups: Group I (vehicle administration only); Group II (diabetes: induce...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2014/631549 |
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| author | Samuel Tung-Hsing Chiang Shang-Min Yeh Yi-Chen Chen Shiun-Long Lin Jung-Kai Tseng |
| author_facet | Samuel Tung-Hsing Chiang Shang-Min Yeh Yi-Chen Chen Shiun-Long Lin Jung-Kai Tseng |
| author_sort | Samuel Tung-Hsing Chiang |
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| description | The purpose of this study was to investigate the protective role of orally administered taurine against diabetic retinal changes via electroretinogram (ERG) and retinal histology on rabbits. Rabbits were randomly assigned into groups: Group I (vehicle administration only); Group II (diabetes: induced by 100 mg/kg alloxan injection); Group III (diabetes and fed with 200 mg/kg taurine); and Group IV (diabetes and fed with 400 mg/kg taurine). The body weight and blood glucose levels of the rabbits were monitored weekly. The ERG was measured on weeks 5 and 15. Retinal histology was analyzed in the end of the experiment. Results revealed that a taurine supplement significantly ameliorates the alloxan-induced hyperglycemia and protects the retina from electrophysiological changes. Group II showed a significant (P<0.05) change in the mean scotopic b-wave amplitude when compared to that of Group I, whereas the diabetic rabbits treated with taurine (Group III and IV) were analogous to Group I. Histologically, the amount of Bipolar and Müller cells showed no difference (P>0.05) between all groups and when compared with those of Group I. Our study provides solid evidences that taurine possesses an antidiabetic activity, reduced loss of body weight, and less electrophysiological changes of the diabetic retina. |
| format | Article |
| id | doaj-art-389874612e594bc5ace5fb29ed0fad99 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-389874612e594bc5ace5fb29ed0fad992025-02-03T01:01:04ZengWileyInternational Journal of Endocrinology1687-83371687-83452014-01-01201410.1155/2014/631549631549Investigation of the Protective Effects of Taurine against Alloxan-Induced Diabetic Retinal Changes via Electroretinogram and Retinal Histology with New Zealand White RabbitsSamuel Tung-Hsing Chiang0Shang-Min Yeh1Yi-Chen Chen2Shiun-Long Lin3Jung-Kai Tseng4Department of Optometry and Vision Science, Faculty of Medical and Health Science, The University of Auckland, 85 Park Road, Grafton, Auckland 1023, New ZealandSchool of Optometry, Chung Shan Medical University, No. 110, Section 1, Jianguo N. Road, Taichung 40201, TaiwanDepartment of Animal Science and Technology, National Taiwan University, No. 50, Lane 155, Section 3, Keelung Road, Taipei 11054, TaiwanDepartment of Veterinary Medicine, National Chung Hsing University, No. 250, Kuo-Kuang Road, Taichung 40227, TaiwanSchool of Optometry, Chung Shan Medical University, No. 110, Section 1, Jianguo N. Road, Taichung 40201, TaiwanThe purpose of this study was to investigate the protective role of orally administered taurine against diabetic retinal changes via electroretinogram (ERG) and retinal histology on rabbits. Rabbits were randomly assigned into groups: Group I (vehicle administration only); Group II (diabetes: induced by 100 mg/kg alloxan injection); Group III (diabetes and fed with 200 mg/kg taurine); and Group IV (diabetes and fed with 400 mg/kg taurine). The body weight and blood glucose levels of the rabbits were monitored weekly. The ERG was measured on weeks 5 and 15. Retinal histology was analyzed in the end of the experiment. Results revealed that a taurine supplement significantly ameliorates the alloxan-induced hyperglycemia and protects the retina from electrophysiological changes. Group II showed a significant (P<0.05) change in the mean scotopic b-wave amplitude when compared to that of Group I, whereas the diabetic rabbits treated with taurine (Group III and IV) were analogous to Group I. Histologically, the amount of Bipolar and Müller cells showed no difference (P>0.05) between all groups and when compared with those of Group I. Our study provides solid evidences that taurine possesses an antidiabetic activity, reduced loss of body weight, and less electrophysiological changes of the diabetic retina.http://dx.doi.org/10.1155/2014/631549 |
| spellingShingle | Samuel Tung-Hsing Chiang Shang-Min Yeh Yi-Chen Chen Shiun-Long Lin Jung-Kai Tseng Investigation of the Protective Effects of Taurine against Alloxan-Induced Diabetic Retinal Changes via Electroretinogram and Retinal Histology with New Zealand White Rabbits International Journal of Endocrinology |
| title | Investigation of the Protective Effects of Taurine against Alloxan-Induced Diabetic Retinal Changes via Electroretinogram and Retinal Histology with New Zealand White Rabbits |
| title_full | Investigation of the Protective Effects of Taurine against Alloxan-Induced Diabetic Retinal Changes via Electroretinogram and Retinal Histology with New Zealand White Rabbits |
| title_fullStr | Investigation of the Protective Effects of Taurine against Alloxan-Induced Diabetic Retinal Changes via Electroretinogram and Retinal Histology with New Zealand White Rabbits |
| title_full_unstemmed | Investigation of the Protective Effects of Taurine against Alloxan-Induced Diabetic Retinal Changes via Electroretinogram and Retinal Histology with New Zealand White Rabbits |
| title_short | Investigation of the Protective Effects of Taurine against Alloxan-Induced Diabetic Retinal Changes via Electroretinogram and Retinal Histology with New Zealand White Rabbits |
| title_sort | investigation of the protective effects of taurine against alloxan induced diabetic retinal changes via electroretinogram and retinal histology with new zealand white rabbits |
| url | http://dx.doi.org/10.1155/2014/631549 |
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