LncRNA FEZF1-AS1 Promotes TGF-β2-Mediated Proliferation and Migration in Human Lens Epithelial Cells SRA01/04
Posterior capsule opacification (PCO) is a common complication after cataract surgery attributed to the proliferation and migration of postoperative residual lens epithelial cells (LECs). The long noncoding RNA (lncRNA) FEZ family zinc finger 1 antisense RNA 1 (FEZF1-AS1) promotes the proliferation...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2019/4736203 |
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| author | Yong Wang Lili Chen Yonghui Gu Ying Wang You Yuan Qiujian Zhu Mingchao Bi Shuyan Gu |
| author_facet | Yong Wang Lili Chen Yonghui Gu Ying Wang You Yuan Qiujian Zhu Mingchao Bi Shuyan Gu |
| author_sort | Yong Wang |
| collection | DOAJ |
| description | Posterior capsule opacification (PCO) is a common complication after cataract surgery attributed to the proliferation and migration of postoperative residual lens epithelial cells (LECs). The long noncoding RNA (lncRNA) FEZ family zinc finger 1 antisense RNA 1 (FEZF1-AS1) promotes the proliferation and migration of multiple types of cancer cells. Here, we discovered that FEZF1-AS1 is markedly upregulated in TGF-β2-treated SRA01/04 cells. In addition, the proliferation and migration of SRA01/04 cells were enhanced following TGF-β2 treatment. FEZF1-AS1 knockdown inhibited the TGF-β2-induced proliferation and migration of SRA01/04 cells. Accordingly, FEZF1-AS1 overexpression promoted the TGF-β2-induced proliferation and migration of SRA01/04 cells. Finally, FEZF1-AS1 upregulated TGF-β2-induced SRA01/04 cell proliferation and migration via boosting FEZF1 protein levels. Our findings indicate that the dysregulation of FEZF1-AS1 participates in the TGF-β2-induced proliferation and migration of human lens epithelial cells (HLECs), which might be achieved, at least in part, through the induction of FEZF1 expression. |
| format | Article |
| id | doaj-art-38943524c9be4d05a4635551f59c7787 |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-38943524c9be4d05a4635551f59c77872025-02-03T01:31:50ZengWileyJournal of Ophthalmology2090-004X2090-00582019-01-01201910.1155/2019/47362034736203LncRNA FEZF1-AS1 Promotes TGF-β2-Mediated Proliferation and Migration in Human Lens Epithelial Cells SRA01/04Yong Wang0Lili Chen1Yonghui Gu2Ying Wang3You Yuan4Qiujian Zhu5Mingchao Bi6Shuyan Gu7Aier School of Ophthalmology, Central South University, Changsha, Hunan, ChinaDepartment of Ophthalmology, Lixiang Eye Hospital of Soochow University, Suzhou, Jiangsu, ChinaDepartment of Ophthalmology, Suzhou Municipal Hospital, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, Jiangsu, ChinaDepartment of Ophthalmology, Suzhou Municipal Hospital, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, Jiangsu, ChinaDepartment of Ophthalmology, Lixiang Eye Hospital of Soochow University, Suzhou, Jiangsu, ChinaDepartment of Ophthalmology, Lixiang Eye Hospital of Soochow University, Suzhou, Jiangsu, ChinaDepartment of Ophthalmology, The First Hospital, Jilin University, Changchun, Jilin, ChinaAier School of Ophthalmology, Central South University, Changsha, Hunan, ChinaPosterior capsule opacification (PCO) is a common complication after cataract surgery attributed to the proliferation and migration of postoperative residual lens epithelial cells (LECs). The long noncoding RNA (lncRNA) FEZ family zinc finger 1 antisense RNA 1 (FEZF1-AS1) promotes the proliferation and migration of multiple types of cancer cells. Here, we discovered that FEZF1-AS1 is markedly upregulated in TGF-β2-treated SRA01/04 cells. In addition, the proliferation and migration of SRA01/04 cells were enhanced following TGF-β2 treatment. FEZF1-AS1 knockdown inhibited the TGF-β2-induced proliferation and migration of SRA01/04 cells. Accordingly, FEZF1-AS1 overexpression promoted the TGF-β2-induced proliferation and migration of SRA01/04 cells. Finally, FEZF1-AS1 upregulated TGF-β2-induced SRA01/04 cell proliferation and migration via boosting FEZF1 protein levels. Our findings indicate that the dysregulation of FEZF1-AS1 participates in the TGF-β2-induced proliferation and migration of human lens epithelial cells (HLECs), which might be achieved, at least in part, through the induction of FEZF1 expression.http://dx.doi.org/10.1155/2019/4736203 |
| spellingShingle | Yong Wang Lili Chen Yonghui Gu Ying Wang You Yuan Qiujian Zhu Mingchao Bi Shuyan Gu LncRNA FEZF1-AS1 Promotes TGF-β2-Mediated Proliferation and Migration in Human Lens Epithelial Cells SRA01/04 Journal of Ophthalmology |
| title | LncRNA FEZF1-AS1 Promotes TGF-β2-Mediated Proliferation and Migration in Human Lens Epithelial Cells SRA01/04 |
| title_full | LncRNA FEZF1-AS1 Promotes TGF-β2-Mediated Proliferation and Migration in Human Lens Epithelial Cells SRA01/04 |
| title_fullStr | LncRNA FEZF1-AS1 Promotes TGF-β2-Mediated Proliferation and Migration in Human Lens Epithelial Cells SRA01/04 |
| title_full_unstemmed | LncRNA FEZF1-AS1 Promotes TGF-β2-Mediated Proliferation and Migration in Human Lens Epithelial Cells SRA01/04 |
| title_short | LncRNA FEZF1-AS1 Promotes TGF-β2-Mediated Proliferation and Migration in Human Lens Epithelial Cells SRA01/04 |
| title_sort | lncrna fezf1 as1 promotes tgf β2 mediated proliferation and migration in human lens epithelial cells sra01 04 |
| url | http://dx.doi.org/10.1155/2019/4736203 |
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