Mucin-Poor Mucinous Tubular and Spindle Cell Carcinoma of the Kidney Presented with Multiple Metastases Two Years after Nephrectomy: An Atypical Behaviour of a Rare, Indolent Tumour
Background. Mucinous tubular and spindle cell carcinoma (MTSCC) is a rare type of renal cell carcinoma, whose clinical behaviour and metastatic potential have not been fully elucidated to date. There are only a few metastatic cases in the literature, which all either featured sarcomatoid differentia...
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| Language: | English |
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2017-01-01
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| Series: | Case Reports in Urology |
| Online Access: | http://dx.doi.org/10.1155/2017/6597592 |
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| author | I. Sokolakis C. Kalogirou L. Frey M. Oelschläger M. Krebs H. Riedmiller H. Kübler D. Vergho |
| author_facet | I. Sokolakis C. Kalogirou L. Frey M. Oelschläger M. Krebs H. Riedmiller H. Kübler D. Vergho |
| author_sort | I. Sokolakis |
| collection | DOAJ |
| description | Background. Mucinous tubular and spindle cell carcinoma (MTSCC) is a rare type of renal cell carcinoma, whose clinical behaviour and metastatic potential have not been fully elucidated to date. There are only a few metastatic cases in the literature, which all either featured sarcomatoid differentiation or were synchronously metastasised at diagnosis. Case Presentation. We report a case of a 49-year-old male with end-stage kidney disease on dialysis, presenting with multiple osseous metastases of a mucin-poor variant of MTSCC of the kidney, without sarcomatoid differentiation, two years after bilateral nephrectomy for papillary renal cell carcinoma (RCC) at a curable stage. After retrospectively reexamining the initial nephrectomy specimens, the tumour of the right kidney was also diagnosed as a mucin-poor variant of MTSCC, while the tumour of the left kidney was confirmed as a papillary RCC. Conclusions. It is proposed that MTSCC can be associated with end-stage renal disease and that particularly the mucin-poor variant is easily confused with papillary renal cell carcinoma, as happened in this case. Although it is considered as a relatively indolent malign entity, it can metastasise even years after successful primary surgical treatment. This implies, besides accurate diagnosis, that MTSCC patients should be monitored closely in the follow-up period. |
| format | Article |
| id | doaj-art-3882013d29ab4366bd977eb034e9ed00 |
| institution | Kabale University |
| issn | 2090-696X 2090-6978 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Urology |
| spelling | doaj-art-3882013d29ab4366bd977eb034e9ed002025-02-03T06:13:18ZengWileyCase Reports in Urology2090-696X2090-69782017-01-01201710.1155/2017/65975926597592Mucin-Poor Mucinous Tubular and Spindle Cell Carcinoma of the Kidney Presented with Multiple Metastases Two Years after Nephrectomy: An Atypical Behaviour of a Rare, Indolent TumourI. Sokolakis0C. Kalogirou1L. Frey2M. Oelschläger3M. Krebs4H. Riedmiller5H. Kübler6D. Vergho7Department of Urology and Paediatric Urology, Julius Maximilian University of Würzburg, Würzburg, GermanyDepartment of Urology and Paediatric Urology, Julius Maximilian University of Würzburg, Würzburg, GermanyInstitute of Pathology, Julius Maximilian University of Würzburg, Würzburg, GermanyDepartment of Urology and Paediatric Urology, Julius Maximilian University of Würzburg, Würzburg, GermanyDepartment of Urology and Paediatric Urology, Julius Maximilian University of Würzburg, Würzburg, GermanyDepartment of Urology and Paediatric Urology, Julius Maximilian University of Würzburg, Würzburg, GermanyDepartment of Urology and Paediatric Urology, Julius Maximilian University of Würzburg, Würzburg, GermanyDepartment of Urology and Paediatric Urology, Julius Maximilian University of Würzburg, Würzburg, GermanyBackground. Mucinous tubular and spindle cell carcinoma (MTSCC) is a rare type of renal cell carcinoma, whose clinical behaviour and metastatic potential have not been fully elucidated to date. There are only a few metastatic cases in the literature, which all either featured sarcomatoid differentiation or were synchronously metastasised at diagnosis. Case Presentation. We report a case of a 49-year-old male with end-stage kidney disease on dialysis, presenting with multiple osseous metastases of a mucin-poor variant of MTSCC of the kidney, without sarcomatoid differentiation, two years after bilateral nephrectomy for papillary renal cell carcinoma (RCC) at a curable stage. After retrospectively reexamining the initial nephrectomy specimens, the tumour of the right kidney was also diagnosed as a mucin-poor variant of MTSCC, while the tumour of the left kidney was confirmed as a papillary RCC. Conclusions. It is proposed that MTSCC can be associated with end-stage renal disease and that particularly the mucin-poor variant is easily confused with papillary renal cell carcinoma, as happened in this case. Although it is considered as a relatively indolent malign entity, it can metastasise even years after successful primary surgical treatment. This implies, besides accurate diagnosis, that MTSCC patients should be monitored closely in the follow-up period.http://dx.doi.org/10.1155/2017/6597592 |
| spellingShingle | I. Sokolakis C. Kalogirou L. Frey M. Oelschläger M. Krebs H. Riedmiller H. Kübler D. Vergho Mucin-Poor Mucinous Tubular and Spindle Cell Carcinoma of the Kidney Presented with Multiple Metastases Two Years after Nephrectomy: An Atypical Behaviour of a Rare, Indolent Tumour Case Reports in Urology |
| title | Mucin-Poor Mucinous Tubular and Spindle Cell Carcinoma of the Kidney Presented with Multiple Metastases Two Years after Nephrectomy: An Atypical Behaviour of a Rare, Indolent Tumour |
| title_full | Mucin-Poor Mucinous Tubular and Spindle Cell Carcinoma of the Kidney Presented with Multiple Metastases Two Years after Nephrectomy: An Atypical Behaviour of a Rare, Indolent Tumour |
| title_fullStr | Mucin-Poor Mucinous Tubular and Spindle Cell Carcinoma of the Kidney Presented with Multiple Metastases Two Years after Nephrectomy: An Atypical Behaviour of a Rare, Indolent Tumour |
| title_full_unstemmed | Mucin-Poor Mucinous Tubular and Spindle Cell Carcinoma of the Kidney Presented with Multiple Metastases Two Years after Nephrectomy: An Atypical Behaviour of a Rare, Indolent Tumour |
| title_short | Mucin-Poor Mucinous Tubular and Spindle Cell Carcinoma of the Kidney Presented with Multiple Metastases Two Years after Nephrectomy: An Atypical Behaviour of a Rare, Indolent Tumour |
| title_sort | mucin poor mucinous tubular and spindle cell carcinoma of the kidney presented with multiple metastases two years after nephrectomy an atypical behaviour of a rare indolent tumour |
| url | http://dx.doi.org/10.1155/2017/6597592 |
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