Assessment and incorporation of in vitro correlates to pharmacokinetic outcomes in antibody developability workflows

Assessment and incorporation of in vitro correlates to pharmacokinetic outcomes in antibody developability workflows

In vitro assessments for the prediction of pharmacokinetic (PK) behavior of biotherapeutics can help identify corresponding liabilities significantly earlier in the discovery timeline. This can minimize the need for extensive early in vivo PK characterization, thereby reducing animal usage and optim...

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Bibliographic Details
Main Authors: Tushar Jain, Bianka Prinz, Alexander Marker, Alexander Michel, Katrin Reichel, Valerie Czepczor, Sylvie Klieber, Wei Sun, Sagar Kathuria, Sevim Oezguer Bruederle, Christian Lange, Lena Wahl, Charles Starr, Alessandro Masiero, Lindsay Avery
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:mAbs
Subjects:
Antibodies
biotherapeutics
developability
in silico prediction
in vitro measurement
in vivo assessment
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2024.2384104
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