Signaling pathway mechanisms of circadian clock gene Bmal1 regulating bone and cartilage metabolism: a review
Abstract Circadian rhythm is ubiquitous in nature. Circadian clock genes such as Bmal1 and Clock form a multi-level transcription-translation feedback network, and regulate a variety of physiological and pathological processes, including bone and cartilage metabolism. Deletion of the core clock gene...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2025-01-01
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| Series: | Bone Research |
| Online Access: | https://doi.org/10.1038/s41413-025-00403-6 |
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| author | Yiting Ze Yongyao Wu Zhen Tan Rui Li Rong Li Wenzhen Gao Qing Zhao |
| author_facet | Yiting Ze Yongyao Wu Zhen Tan Rui Li Rong Li Wenzhen Gao Qing Zhao |
| author_sort | Yiting Ze |
| collection | DOAJ |
| description | Abstract Circadian rhythm is ubiquitous in nature. Circadian clock genes such as Bmal1 and Clock form a multi-level transcription-translation feedback network, and regulate a variety of physiological and pathological processes, including bone and cartilage metabolism. Deletion of the core clock gene Bmal1 leads to pathological bone alterations, while the phenotypes are not consistent. Studies have shown that multiple signaling pathways are involved in the process of Bmal1 regulating bone and cartilage metabolism, but the exact regulatory mechanisms remain unclear. This paper reviews the signaling pathways by which Bmal1 regulates bone/cartilage metabolism, the upstream regulatory factors that control Bmal1, and the current Bmal1 knockout mouse models for research. We hope to provide new insights for the prevention and treatment of bone/cartilage diseases related to circadian rhythms. |
| format | Article |
| id | doaj-art-387bce4d99aa46adb133a9face64492a |
| institution | Kabale University |
| issn | 2095-6231 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Bone Research |
| spelling | doaj-art-387bce4d99aa46adb133a9face64492a2025-02-02T12:12:37ZengNature Publishing GroupBone Research2095-62312025-01-0113111310.1038/s41413-025-00403-6Signaling pathway mechanisms of circadian clock gene Bmal1 regulating bone and cartilage metabolism: a reviewYiting Ze0Yongyao Wu1Zhen Tan2Rui Li3Rong Li4Wenzhen Gao5Qing Zhao6Department of Orthodontics, State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan UniversityDepartment of Orthodontics, State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan UniversityDepartment of Implant Dentistry, State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan UniversityDepartment of Orthodontics, State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan UniversityDepartment of Orthodontics, State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan UniversityDepartment of Orthodontics, State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan UniversityDepartment of Orthodontics, State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan UniversityAbstract Circadian rhythm is ubiquitous in nature. Circadian clock genes such as Bmal1 and Clock form a multi-level transcription-translation feedback network, and regulate a variety of physiological and pathological processes, including bone and cartilage metabolism. Deletion of the core clock gene Bmal1 leads to pathological bone alterations, while the phenotypes are not consistent. Studies have shown that multiple signaling pathways are involved in the process of Bmal1 regulating bone and cartilage metabolism, but the exact regulatory mechanisms remain unclear. This paper reviews the signaling pathways by which Bmal1 regulates bone/cartilage metabolism, the upstream regulatory factors that control Bmal1, and the current Bmal1 knockout mouse models for research. We hope to provide new insights for the prevention and treatment of bone/cartilage diseases related to circadian rhythms.https://doi.org/10.1038/s41413-025-00403-6 |
| spellingShingle | Yiting Ze Yongyao Wu Zhen Tan Rui Li Rong Li Wenzhen Gao Qing Zhao Signaling pathway mechanisms of circadian clock gene Bmal1 regulating bone and cartilage metabolism: a review Bone Research |
| title | Signaling pathway mechanisms of circadian clock gene Bmal1 regulating bone and cartilage metabolism: a review |
| title_full | Signaling pathway mechanisms of circadian clock gene Bmal1 regulating bone and cartilage metabolism: a review |
| title_fullStr | Signaling pathway mechanisms of circadian clock gene Bmal1 regulating bone and cartilage metabolism: a review |
| title_full_unstemmed | Signaling pathway mechanisms of circadian clock gene Bmal1 regulating bone and cartilage metabolism: a review |
| title_short | Signaling pathway mechanisms of circadian clock gene Bmal1 regulating bone and cartilage metabolism: a review |
| title_sort | signaling pathway mechanisms of circadian clock gene bmal1 regulating bone and cartilage metabolism a review |
| url | https://doi.org/10.1038/s41413-025-00403-6 |
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