Associations between left atrial indices and cardiorespiratory and muscular fitness among physically active military personnel
BackgroundLeft atrial (LA) size and function are linked to exercise intolerance in heart failure, while associations between LA parameters and exercise performance remain unclear in athletes.ObjectivesThis study aimed to identify correlations between echocardiographic LA size, pressure, stiffness, a...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2025.1435818/full |
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| author | Yen-Chen Lin Yen-Chen Lin Pang-Yen Liu Kun-Zhe Tsai Kun-Zhe Tsai Kun-Zhe Tsai Wei-Chun Huang Wei-Chun Huang Wen-Chung Yu Wen-Chung Yu Xuemei Sui Carl J. Lavie Gen-Min Lin Gen-Min Lin |
| author_facet | Yen-Chen Lin Yen-Chen Lin Pang-Yen Liu Kun-Zhe Tsai Kun-Zhe Tsai Kun-Zhe Tsai Wei-Chun Huang Wei-Chun Huang Wen-Chung Yu Wen-Chung Yu Xuemei Sui Carl J. Lavie Gen-Min Lin Gen-Min Lin |
| author_sort | Yen-Chen Lin |
| collection | DOAJ |
| description | BackgroundLeft atrial (LA) size and function are linked to exercise intolerance in heart failure, while associations between LA parameters and exercise performance remain unclear in athletes.ObjectivesThis study aimed to identify correlations between echocardiographic LA size, pressure, stiffness, and composite indices, and various exercise performance indicators.MethodsEchocardiographic parameters were obtained from 181 physically active military personnel receiving regular training and tests for a 3-km run and 2 min of push-ups and sit-ups. The top 16% of runners were compared sex-specifically, with the remaining 84% as controls to identify LA discriminators for running capacity. LA composite indices were defined as the LA volume index (LAVI) divided by the stiffness index (LASI) or pressure index (mitral E/e′). Spearman correlations were used to identify LA correlates with exercise performance. Generalized linear regressions were used to identify LA predictors of exercise performance with adjustments for potential covariates.ResultsThe top 16% of runners vs. controls had a lower LASI based on LA volume changes (LASI_v, 0.196 vs. 0.245, p = 0.013) and higher LAVI-to-LASI_v (12.30 vs. 8.08, p = 0.001) and LAVI-to-(mitral E/e′) (4.37 vs. 3.76, p = 0.038) ratios. The LAVI-to-LASI_v ratio was the most highly correlated shared LA parameter for running (|rho| = 0.403), push-up (rho = 0.335), and sit-up (rho = 0.352) performance. The LAVI-to-mitral E/e′ ratio was the most highly correlated, independent, and unique LA parameter for running (|rho| = 0.457) performance.ConclusionsThe LAVI-to-LASI_v ratio, comprising LA size and stiffness information, was the best correlate across exercise types, while the LAVI-to-mitral E/e′ ratio, comprising LA size and pressure information, was the best correlate of an endurance exercise, i.e., 3-km running performance. |
| format | Article |
| id | doaj-art-3873f9bafb3e469bb7775989cd0ce402 |
| institution | Kabale University |
| issn | 2297-055X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj-art-3873f9bafb3e469bb7775989cd0ce4022025-01-31T06:41:05ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2025-01-011210.3389/fcvm.2025.14358181435818Associations between left atrial indices and cardiorespiratory and muscular fitness among physically active military personnelYen-Chen Lin0Yen-Chen Lin1Pang-Yen Liu2Kun-Zhe Tsai3Kun-Zhe Tsai4Kun-Zhe Tsai5Wei-Chun Huang6Wei-Chun Huang7Wen-Chung Yu8Wen-Chung Yu9Xuemei Sui10Carl J. Lavie11Gen-Min Lin12Gen-Min Lin13Division of Cardiology, Department of Internal Medicine, Linkou Chang Gung Memorial Hospital, Taoyuan, TaiwanGraduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, TaiwanDepartment of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, TaiwanDepartment of Medicine, Hualien Armed Forces General Hospital, Hualien City, TaiwanDepartment of Stomatology of Periodontology, Mackay Memorial Hospital, Taipei, TaiwanDepartment of Periodontology, School of Dentistry, Tri-Service General Hospital, National Defense Medical Center, Taipei, TaiwanDepartment of Medicine, Pingtung Christian Hospital, Pingtung City, Pingtung, TaiwanDepartment of Business Management, National Sun Yat-sen University, Kaohsiung City, TaiwanCollege of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan0Division of Cardiology, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan1Department of Exercise Science, Arnold School of Public Health, University of South Carolina, Columbia, SC, United States2John Ochsner Heart and Vascular Institute, Ochsner Clinical School, The University of Queensland School of Medicine, New Orleans, LA, United StatesDepartment of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, TaiwanDepartment of Medicine, Hualien Armed Forces General Hospital, Hualien City, TaiwanBackgroundLeft atrial (LA) size and function are linked to exercise intolerance in heart failure, while associations between LA parameters and exercise performance remain unclear in athletes.ObjectivesThis study aimed to identify correlations between echocardiographic LA size, pressure, stiffness, and composite indices, and various exercise performance indicators.MethodsEchocardiographic parameters were obtained from 181 physically active military personnel receiving regular training and tests for a 3-km run and 2 min of push-ups and sit-ups. The top 16% of runners were compared sex-specifically, with the remaining 84% as controls to identify LA discriminators for running capacity. LA composite indices were defined as the LA volume index (LAVI) divided by the stiffness index (LASI) or pressure index (mitral E/e′). Spearman correlations were used to identify LA correlates with exercise performance. Generalized linear regressions were used to identify LA predictors of exercise performance with adjustments for potential covariates.ResultsThe top 16% of runners vs. controls had a lower LASI based on LA volume changes (LASI_v, 0.196 vs. 0.245, p = 0.013) and higher LAVI-to-LASI_v (12.30 vs. 8.08, p = 0.001) and LAVI-to-(mitral E/e′) (4.37 vs. 3.76, p = 0.038) ratios. The LAVI-to-LASI_v ratio was the most highly correlated shared LA parameter for running (|rho| = 0.403), push-up (rho = 0.335), and sit-up (rho = 0.352) performance. The LAVI-to-mitral E/e′ ratio was the most highly correlated, independent, and unique LA parameter for running (|rho| = 0.457) performance.ConclusionsThe LAVI-to-LASI_v ratio, comprising LA size and stiffness information, was the best correlate across exercise types, while the LAVI-to-mitral E/e′ ratio, comprising LA size and pressure information, was the best correlate of an endurance exercise, i.e., 3-km running performance.https://www.frontiersin.org/articles/10.3389/fcvm.2025.1435818/fullleft atrial volume index (LAVI)left atrial stiffness index (LASI)left atrial strainexercise performanceathletesechocardiography |
| spellingShingle | Yen-Chen Lin Yen-Chen Lin Pang-Yen Liu Kun-Zhe Tsai Kun-Zhe Tsai Kun-Zhe Tsai Wei-Chun Huang Wei-Chun Huang Wen-Chung Yu Wen-Chung Yu Xuemei Sui Carl J. Lavie Gen-Min Lin Gen-Min Lin Associations between left atrial indices and cardiorespiratory and muscular fitness among physically active military personnel Frontiers in Cardiovascular Medicine left atrial volume index (LAVI) left atrial stiffness index (LASI) left atrial strain exercise performance athletes echocardiography |
| title | Associations between left atrial indices and cardiorespiratory and muscular fitness among physically active military personnel |
| title_full | Associations between left atrial indices and cardiorespiratory and muscular fitness among physically active military personnel |
| title_fullStr | Associations between left atrial indices and cardiorespiratory and muscular fitness among physically active military personnel |
| title_full_unstemmed | Associations between left atrial indices and cardiorespiratory and muscular fitness among physically active military personnel |
| title_short | Associations between left atrial indices and cardiorespiratory and muscular fitness among physically active military personnel |
| title_sort | associations between left atrial indices and cardiorespiratory and muscular fitness among physically active military personnel |
| topic | left atrial volume index (LAVI) left atrial stiffness index (LASI) left atrial strain exercise performance athletes echocardiography |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2025.1435818/full |
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