Photoprotective Effect of the Plant Collaea argentina against Adverse Effects Induced by Photodynamic Therapy
Photodynamic therapy (PDT) is a treatment modality for tumours and other accessible lesions based on the combination of light and a photosensitizer (PS) accumulated in the target tissue. The main disadvantage of PDT is PS retention after treatment during long time periods that conduces to cutaneous...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | International Journal of Photoenergy |
| Online Access: | http://dx.doi.org/10.1155/2014/436463 |
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| author | Leandro Mamone Daniel Sáenz Pablo Vallecorsa Alcira Batlle Adriana Casas Gabriela Di Venosa |
| author_facet | Leandro Mamone Daniel Sáenz Pablo Vallecorsa Alcira Batlle Adriana Casas Gabriela Di Venosa |
| author_sort | Leandro Mamone |
| collection | DOAJ |
| description | Photodynamic therapy (PDT) is a treatment modality for tumours and other accessible lesions based on the combination of light and a photosensitizer (PS) accumulated in the target tissue. The main disadvantage of PDT is PS retention after treatment during long time periods that conduces to cutaneous damage. It is believed that singlet oxygen is responsible for that skin photosensitization. The aim of this work was to evaluate the photoprotective activity of the methanolic extract of the Argentinian plant Collaea argentina against PDT under several treatments and employing different PSs. C. argentina exhibited photoprotective activity against aminolevulinic acid- (ALA-) PDT in the LM2 murine adenocarcinoma cell line. The photoprotection was dependant on the extract concentration and the incubation time, being detectable from 40 μg/mL onwards and at least after 3 h exposure of the cells. C. argentina extract protects these mammalian tumor cells against PDT effects, and it interferes with the oxygen singlet production from PSs during PDT treatment. We propose that it will be a promising agent to protect cells against PDT-induced skin sensitivity. |
| format | Article |
| id | doaj-art-3871f3925f234cb9b9a581082ad29e38 |
| institution | Kabale University |
| issn | 1110-662X 1687-529X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Photoenergy |
| spelling | doaj-art-3871f3925f234cb9b9a581082ad29e382025-02-03T07:23:34ZengWileyInternational Journal of Photoenergy1110-662X1687-529X2014-01-01201410.1155/2014/436463436463Photoprotective Effect of the Plant Collaea argentina against Adverse Effects Induced by Photodynamic TherapyLeandro Mamone0Daniel Sáenz1Pablo Vallecorsa2Alcira Batlle3Adriana Casas4Gabriela Di Venosa5Centro de Investigaciones sobre Porfirinas y Porfirias (CIPYP), CONICET, Hospital de Clínicas José de San Martín, Universidad de Buenos Aires, Córdoba 2351 1er subsuelo, Ciudad de Buenos Aires, 1120AAF Buenos Aires, ArgentinaCentro de Investigaciones sobre Porfirinas y Porfirias (CIPYP), CONICET, Hospital de Clínicas José de San Martín, Universidad de Buenos Aires, Córdoba 2351 1er subsuelo, Ciudad de Buenos Aires, 1120AAF Buenos Aires, ArgentinaCentro de Investigaciones sobre Porfirinas y Porfirias (CIPYP), CONICET, Hospital de Clínicas José de San Martín, Universidad de Buenos Aires, Córdoba 2351 1er subsuelo, Ciudad de Buenos Aires, 1120AAF Buenos Aires, ArgentinaCentro de Investigaciones sobre Porfirinas y Porfirias (CIPYP), CONICET, Hospital de Clínicas José de San Martín, Universidad de Buenos Aires, Córdoba 2351 1er subsuelo, Ciudad de Buenos Aires, 1120AAF Buenos Aires, ArgentinaCentro de Investigaciones sobre Porfirinas y Porfirias (CIPYP), CONICET, Hospital de Clínicas José de San Martín, Universidad de Buenos Aires, Córdoba 2351 1er subsuelo, Ciudad de Buenos Aires, 1120AAF Buenos Aires, ArgentinaCentro de Investigaciones sobre Porfirinas y Porfirias (CIPYP), CONICET, Hospital de Clínicas José de San Martín, Universidad de Buenos Aires, Córdoba 2351 1er subsuelo, Ciudad de Buenos Aires, 1120AAF Buenos Aires, ArgentinaPhotodynamic therapy (PDT) is a treatment modality for tumours and other accessible lesions based on the combination of light and a photosensitizer (PS) accumulated in the target tissue. The main disadvantage of PDT is PS retention after treatment during long time periods that conduces to cutaneous damage. It is believed that singlet oxygen is responsible for that skin photosensitization. The aim of this work was to evaluate the photoprotective activity of the methanolic extract of the Argentinian plant Collaea argentina against PDT under several treatments and employing different PSs. C. argentina exhibited photoprotective activity against aminolevulinic acid- (ALA-) PDT in the LM2 murine adenocarcinoma cell line. The photoprotection was dependant on the extract concentration and the incubation time, being detectable from 40 μg/mL onwards and at least after 3 h exposure of the cells. C. argentina extract protects these mammalian tumor cells against PDT effects, and it interferes with the oxygen singlet production from PSs during PDT treatment. We propose that it will be a promising agent to protect cells against PDT-induced skin sensitivity.http://dx.doi.org/10.1155/2014/436463 |
| spellingShingle | Leandro Mamone Daniel Sáenz Pablo Vallecorsa Alcira Batlle Adriana Casas Gabriela Di Venosa Photoprotective Effect of the Plant Collaea argentina against Adverse Effects Induced by Photodynamic Therapy International Journal of Photoenergy |
| title | Photoprotective Effect of the Plant Collaea argentina against Adverse Effects Induced by Photodynamic Therapy |
| title_full | Photoprotective Effect of the Plant Collaea argentina against Adverse Effects Induced by Photodynamic Therapy |
| title_fullStr | Photoprotective Effect of the Plant Collaea argentina against Adverse Effects Induced by Photodynamic Therapy |
| title_full_unstemmed | Photoprotective Effect of the Plant Collaea argentina against Adverse Effects Induced by Photodynamic Therapy |
| title_short | Photoprotective Effect of the Plant Collaea argentina against Adverse Effects Induced by Photodynamic Therapy |
| title_sort | photoprotective effect of the plant collaea argentina against adverse effects induced by photodynamic therapy |
| url | http://dx.doi.org/10.1155/2014/436463 |
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