Effect of aspirin dosage on oxidative stress and platelet reactivity in patients undergoing coronary artery bypass grafting (APRICOT): randomized controlled trial
Coronary artery bypass grafting (CABG) triggers oxidative stress and platelet activation. High acetylsalicylic acid (ASA) dose might mitigate the transient proinflammatory state. We compared the effect of three ASA dosages on post-CABG platelet reactivity, oxidative stress, and serum CD39 and CD73 l...
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Taylor & Francis Group
2025-12-01
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| Series: | Platelets |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/09537104.2025.2457415 |
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| author | Aleksandra Gąsecka Rafał Kaczorowski Katarzyna Pomykała Tomasz Kucharski Magdalena Gajewska Dominika Siwik Katarzyna Karoń Maciej Małyszko Jaromir Hunia Jakub Michal Zimodro Paweł Kowalczyk Oliwia Zagrocka-Stendel Małgorzata Dutkiewicz Katarzyna Koziak Ceren Eyileten Marek Postuła Mateusz Wondołkowski Marcin Grabowski Mariusz Kuśmierczyk Radosław Wilimski |
| author_facet | Aleksandra Gąsecka Rafał Kaczorowski Katarzyna Pomykała Tomasz Kucharski Magdalena Gajewska Dominika Siwik Katarzyna Karoń Maciej Małyszko Jaromir Hunia Jakub Michal Zimodro Paweł Kowalczyk Oliwia Zagrocka-Stendel Małgorzata Dutkiewicz Katarzyna Koziak Ceren Eyileten Marek Postuła Mateusz Wondołkowski Marcin Grabowski Mariusz Kuśmierczyk Radosław Wilimski |
| author_sort | Aleksandra Gąsecka |
| collection | DOAJ |
| description | Coronary artery bypass grafting (CABG) triggers oxidative stress and platelet activation. High acetylsalicylic acid (ASA) dose might mitigate the transient proinflammatory state. We compared the effect of three ASA dosages on post-CABG platelet reactivity, oxidative stress, and serum CD39 and CD73 levels. Thirty-six consecutive patients undergoing elective off-pump CABG, pre-treated with ASA 1 × 75 mg for ≥7 days, were randomized to continue the prior treatment regimen, switch to ASA 1 × 150 mg, or ASA 2 × 75 mg. Blood was collected on admission, 7 days, 1 month, and 3 months after CABG. Platelet reactivity was assessed using impedance aggregometry. Platelet oxidative stress was measured as platelet mitochondria extracellular oxygen consumption rate and oxidatively damaged whole-blood DNA cleavage. Serum CD39 and CD73 levels were determined using ELISA. Platelet reactivity and oxidative stress parameters were comparable in all groups. Patients treated with ASA 2 × 75 mg had higher CD39 levels at 7 days and 1 month (p = .049, p = .033), compared to the control group. ASA 2 × 75 mg was associated a beneficial effect on serum CD39 levels after off-pump CABG, without a significant effect on oxidative stress parameters. |
| format | Article |
| id | doaj-art-3870a6d13a914f1f8e5d4f0ee1290386 |
| institution | Kabale University |
| issn | 0953-7104 1369-1635 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Platelets |
| spelling | doaj-art-3870a6d13a914f1f8e5d4f0ee12903862025-02-05T12:22:13ZengTaylor & Francis GroupPlatelets0953-71041369-16352025-12-0136110.1080/09537104.2025.2457415Effect of aspirin dosage on oxidative stress and platelet reactivity in patients undergoing coronary artery bypass grafting (APRICOT): randomized controlled trialAleksandra Gąsecka0Rafał Kaczorowski1Katarzyna Pomykała2Tomasz Kucharski3Magdalena Gajewska4Dominika Siwik5Katarzyna Karoń6Maciej Małyszko7Jaromir Hunia8Jakub Michal Zimodro9Paweł Kowalczyk10Oliwia Zagrocka-Stendel11Małgorzata Dutkiewicz12Katarzyna Koziak13Ceren Eyileten14Marek Postuła15Mateusz Wondołkowski16Marcin Grabowski17Mariusz Kuśmierczyk18Radosław Wilimski19Department of Cardiology, Medical University of Warsaw, Warsaw, PolandDepartment of Cardiology, Medical University of Warsaw, Warsaw, PolandDepartment of Cardiology, Medical University of Warsaw, Warsaw, PolandDepartment of Cardiology, Medical University of Warsaw, Warsaw, PolandDepartment of Cardiology, Medical University of Warsaw, Warsaw, PolandDepartment of Psychiatry, Medical University of Warsaw, Warsaw, PolandDepartment of Internal Medicine with the Diabetology and Metabolic Disorders Unit and the Endocrine Diagnostics Unit, Bielański Hospital, Warsaw, PolandDepartment of Gastroenterology and Internal Medicine, Medical University of Warsaw, Warsaw, PolandDepartment of Cardiology, Medical University of Warsaw, Warsaw, PolandDepartment of Cardiology, Medical University of Warsaw, Warsaw, PolandDepartment of Animal Nutrition, The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Jabłonna, PolandDepartment of Immunology, Biochemistry and Nutrition, Medical University of Warsaw, Warsaw, PolandDepartment of Immunology, Biochemistry and Nutrition, Medical University of Warsaw, Warsaw, PolandDepartment of Immunology, Biochemistry and Nutrition, Medical University of Warsaw, Warsaw, PolandDepartment of Experimental and Clinical Pharmacology, Medical University of Warsaw, Warsaw, PolandDepartment of Experimental and Clinical Pharmacology, Medical University of Warsaw, Warsaw, PolandDepartment of Cardio-Thoracic Surgery and Transplantology, Medical University of Warsaw, Warsaw, PolandDepartment of Cardiology, Medical University of Warsaw, Warsaw, PolandDepartment of Cardio-Thoracic Surgery and Transplantology, Medical University of Warsaw, Warsaw, PolandDepartment of Cardio-Thoracic Surgery and Transplantology, Medical University of Warsaw, Warsaw, PolandCoronary artery bypass grafting (CABG) triggers oxidative stress and platelet activation. High acetylsalicylic acid (ASA) dose might mitigate the transient proinflammatory state. We compared the effect of three ASA dosages on post-CABG platelet reactivity, oxidative stress, and serum CD39 and CD73 levels. Thirty-six consecutive patients undergoing elective off-pump CABG, pre-treated with ASA 1 × 75 mg for ≥7 days, were randomized to continue the prior treatment regimen, switch to ASA 1 × 150 mg, or ASA 2 × 75 mg. Blood was collected on admission, 7 days, 1 month, and 3 months after CABG. Platelet reactivity was assessed using impedance aggregometry. Platelet oxidative stress was measured as platelet mitochondria extracellular oxygen consumption rate and oxidatively damaged whole-blood DNA cleavage. Serum CD39 and CD73 levels were determined using ELISA. Platelet reactivity and oxidative stress parameters were comparable in all groups. Patients treated with ASA 2 × 75 mg had higher CD39 levels at 7 days and 1 month (p = .049, p = .033), compared to the control group. ASA 2 × 75 mg was associated a beneficial effect on serum CD39 levels after off-pump CABG, without a significant effect on oxidative stress parameters.https://www.tandfonline.com/doi/10.1080/09537104.2025.2457415Acetylsalicylic acidASAcoronary artery bypass graftingoxidative stressplatelet reactivity |
| spellingShingle | Aleksandra Gąsecka Rafał Kaczorowski Katarzyna Pomykała Tomasz Kucharski Magdalena Gajewska Dominika Siwik Katarzyna Karoń Maciej Małyszko Jaromir Hunia Jakub Michal Zimodro Paweł Kowalczyk Oliwia Zagrocka-Stendel Małgorzata Dutkiewicz Katarzyna Koziak Ceren Eyileten Marek Postuła Mateusz Wondołkowski Marcin Grabowski Mariusz Kuśmierczyk Radosław Wilimski Effect of aspirin dosage on oxidative stress and platelet reactivity in patients undergoing coronary artery bypass grafting (APRICOT): randomized controlled trial Platelets Acetylsalicylic acid ASA coronary artery bypass grafting oxidative stress platelet reactivity |
| title | Effect of aspirin dosage on oxidative stress and platelet reactivity in patients undergoing coronary artery bypass grafting (APRICOT): randomized controlled trial |
| title_full | Effect of aspirin dosage on oxidative stress and platelet reactivity in patients undergoing coronary artery bypass grafting (APRICOT): randomized controlled trial |
| title_fullStr | Effect of aspirin dosage on oxidative stress and platelet reactivity in patients undergoing coronary artery bypass grafting (APRICOT): randomized controlled trial |
| title_full_unstemmed | Effect of aspirin dosage on oxidative stress and platelet reactivity in patients undergoing coronary artery bypass grafting (APRICOT): randomized controlled trial |
| title_short | Effect of aspirin dosage on oxidative stress and platelet reactivity in patients undergoing coronary artery bypass grafting (APRICOT): randomized controlled trial |
| title_sort | effect of aspirin dosage on oxidative stress and platelet reactivity in patients undergoing coronary artery bypass grafting apricot randomized controlled trial |
| topic | Acetylsalicylic acid ASA coronary artery bypass grafting oxidative stress platelet reactivity |
| url | https://www.tandfonline.com/doi/10.1080/09537104.2025.2457415 |
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