Overcoming the Silencing of Doxycycline-Inducible Promoters in hiPSC-derived Cardiomyocytes [version 1; peer review: 1 approved, 2 approved with reservations]

Overcoming the Silencing of Doxycycline-Inducible Promoters in hiPSC-derived Cardiomyocytes [version 1; peer review: 1 approved, 2 approved with reservations]

Background Human induced pluripotent stem cells (hiPSCs) are pivotal for studying human development, modeling diseases, and advancing regenerative medicine. Effective control of transgene expression is crucial to achieve temporal and quantitative precision in all of these contexts. The doxycycline (...

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Bibliographic Details
Main Authors: Michelle Guichardaz, Elisa Balmas, Alessandro Bertero, Sveva Bottini
Format: Article
Language:English
Published: F1000 Research Ltd 2024-12-01
Series:Open Research Europe
Subjects:
Human induced pluripotent stem cells
cardiomyocytes
inducible expression
silencing
TRE3VG promoter
T11 promoter
eng
Online Access:https://open-research-europe.ec.europa.eu/articles/4-266/v1
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