P53 and PIK3CA Mutations in KRAS/HER2 Negative Ovarian Intestinal-Type Mucinous Carcinoma Associated with Mature Teratoma
Primary ovarian intestinal-type mucinous carcinomas associated with mature teratoma are rare and represent less than 3% of all primary ovarian neoplasms. The molecular profile of these tumors is still controversial. We report here the first case of mucinous ovarian tumor in which mutation of the PIK...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Case Reports in Obstetrics and Gynecology |
| Online Access: | http://dx.doi.org/10.1155/2020/8863610 |
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| author | Sarah Bouri Philippe Simon Nicky D’Haene Xavier Catteau Jean-Christophe Noël |
| author_facet | Sarah Bouri Philippe Simon Nicky D’Haene Xavier Catteau Jean-Christophe Noël |
| author_sort | Sarah Bouri |
| collection | DOAJ |
| description | Primary ovarian intestinal-type mucinous carcinomas associated with mature teratoma are rare and represent less than 3% of all primary ovarian neoplasms. The molecular profile of these tumors is still controversial. We report here the first case of mucinous ovarian tumor in which mutation of the PIK3CA and P53 genes could be demonstrated by the next generation sequencing technique without KRAS mutation or HER2 amplification. Our data suggest that these mucinous carcinoma variants probably present an extremely complex molecular biology profile that should be known in the future to stratify therapeutic outcomes and potential targeted therapies, particularly in recurrent disease. |
| format | Article |
| id | doaj-art-385fb04c9ee64c3ea1fdc536c452d00b |
| institution | Kabale University |
| issn | 2090-6684 2090-6692 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Obstetrics and Gynecology |
| spelling | doaj-art-385fb04c9ee64c3ea1fdc536c452d00b2025-02-03T06:43:45ZengWileyCase Reports in Obstetrics and Gynecology2090-66842090-66922020-01-01202010.1155/2020/88636108863610P53 and PIK3CA Mutations in KRAS/HER2 Negative Ovarian Intestinal-Type Mucinous Carcinoma Associated with Mature TeratomaSarah Bouri0Philippe Simon1Nicky D’Haene2Xavier Catteau3Jean-Christophe Noël4Department of Pathology, Erasme University Hospital, Université Libre de Bruxelles, Brussels, BelgiumDepartment of Gynecology, Erasme University Hospital, Université Libre de Bruxelles, Brussels, BelgiumDepartment of Pathology, Erasme University Hospital, Université Libre de Bruxelles, Brussels, BelgiumDepartment of Pathology, Erasme University Hospital, Université Libre de Bruxelles, Brussels, BelgiumDepartment of Pathology, Erasme University Hospital, Université Libre de Bruxelles, Brussels, BelgiumPrimary ovarian intestinal-type mucinous carcinomas associated with mature teratoma are rare and represent less than 3% of all primary ovarian neoplasms. The molecular profile of these tumors is still controversial. We report here the first case of mucinous ovarian tumor in which mutation of the PIK3CA and P53 genes could be demonstrated by the next generation sequencing technique without KRAS mutation or HER2 amplification. Our data suggest that these mucinous carcinoma variants probably present an extremely complex molecular biology profile that should be known in the future to stratify therapeutic outcomes and potential targeted therapies, particularly in recurrent disease.http://dx.doi.org/10.1155/2020/8863610 |
| spellingShingle | Sarah Bouri Philippe Simon Nicky D’Haene Xavier Catteau Jean-Christophe Noël P53 and PIK3CA Mutations in KRAS/HER2 Negative Ovarian Intestinal-Type Mucinous Carcinoma Associated with Mature Teratoma Case Reports in Obstetrics and Gynecology |
| title | P53 and PIK3CA Mutations in KRAS/HER2 Negative Ovarian Intestinal-Type Mucinous Carcinoma Associated with Mature Teratoma |
| title_full | P53 and PIK3CA Mutations in KRAS/HER2 Negative Ovarian Intestinal-Type Mucinous Carcinoma Associated with Mature Teratoma |
| title_fullStr | P53 and PIK3CA Mutations in KRAS/HER2 Negative Ovarian Intestinal-Type Mucinous Carcinoma Associated with Mature Teratoma |
| title_full_unstemmed | P53 and PIK3CA Mutations in KRAS/HER2 Negative Ovarian Intestinal-Type Mucinous Carcinoma Associated with Mature Teratoma |
| title_short | P53 and PIK3CA Mutations in KRAS/HER2 Negative Ovarian Intestinal-Type Mucinous Carcinoma Associated with Mature Teratoma |
| title_sort | p53 and pik3ca mutations in kras her2 negative ovarian intestinal type mucinous carcinoma associated with mature teratoma |
| url | http://dx.doi.org/10.1155/2020/8863610 |
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