Immune Activation, Immunosenescence, and Osteoprotegerin as Markers of Endothelial Dysfunction in Subclinical HIV-Associated Atherosclerosis
HIV-infected patients have a significantly greater risk of cardiovascular disease. Several markers including osteoprotegerin have been shown to be involved in the development and progression of atherosclerosis. We investigated the relationship between T-cell phenotype, osteoprotegerin, and atheroscl...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2014/192594 |
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| author | Alessandra D’Abramo Maria Antonella Zingaropoli Alessandra Oliva Claudia D’Agostino Samir Al Moghazi Giulia De Luca Marco Iannetta Claudio Maria Mastroianni Vincenzo Vullo |
| author_facet | Alessandra D’Abramo Maria Antonella Zingaropoli Alessandra Oliva Claudia D’Agostino Samir Al Moghazi Giulia De Luca Marco Iannetta Claudio Maria Mastroianni Vincenzo Vullo |
| author_sort | Alessandra D’Abramo |
| collection | DOAJ |
| description | HIV-infected patients have a significantly greater risk of cardiovascular disease. Several markers including osteoprotegerin have been shown to be involved in the development and progression of atherosclerosis. We investigated the relationship between T-cell phenotype, osteoprotegerin, and atherosclerosis evaluated by carotid intima-media thickness (c-IMT) in 94 HIV+ patients on suppressive antiretroviral therapy with Framingham score <10%. As for the control group, 24 HIV-negative subjects were enrolled. c-IMT was assessed by ultrasound. CD4+/CD8+ T-cell activation (CD38+ HLADR+) and senescence (CD57+ CD28−) were measured by flow cytometry. IL-6 and OPG levels were measured by ELISA kit. c-IMT was higher in HIV+ than in controls. Among HIV+ patients, 44.7% had pathological c-IMT (≥0.9 mm). CD8+ T-cell activation and senescence and OPG plasma levels were higher in HIV+ patients than in controls. Subjects with pathological c-IMT exhibited higher CD8+ immune activation and immunosenescence and OPG levels than subjects with normal c-IMT. Multivariate analysis showed that age, CD8+ CD38+ HLADR+, and CD8+ CD28− CD57+ were independently associated with pathological c-IMT. Several factors have been implicated in the pathogenesis of atherosclerosis in HIV patients. Immune activation and immunosenescence of CD8+ T cell together with OPG plasma levels might be associated with the development and progression of early atherosclerosis, even in the case of viral suppression. |
| format | Article |
| id | doaj-art-385688c4369342a5a3717a2a2fe0144f |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-385688c4369342a5a3717a2a2fe0144f2025-02-03T05:49:31ZengWileyMediators of Inflammation0962-93511466-18612014-01-01201410.1155/2014/192594192594Immune Activation, Immunosenescence, and Osteoprotegerin as Markers of Endothelial Dysfunction in Subclinical HIV-Associated AtherosclerosisAlessandra D’Abramo0Maria Antonella Zingaropoli1Alessandra Oliva2Claudia D’Agostino3Samir Al Moghazi4Giulia De Luca5Marco Iannetta6Claudio Maria Mastroianni7Vincenzo Vullo8Department of Public Health and Infectious Diseases, “ Sapienza” University of Rome, Viale del Policlinico 155, 00161 Rome, ItalyDepartment of Public Health and Infectious Diseases, “ Sapienza” University of Rome, Viale del Policlinico 155, 00161 Rome, ItalyDepartment of Public Health and Infectious Diseases, “ Sapienza” University of Rome, Viale del Policlinico 155, 00161 Rome, ItalyDepartment of Public Health and Infectious Diseases, “ Sapienza” University of Rome, Viale del Policlinico 155, 00161 Rome, ItalyDepartment of Public Health and Infectious Diseases, “ Sapienza” University of Rome, Viale del Policlinico 155, 00161 Rome, ItalyDepartment of Public Health and Infectious Diseases, “ Sapienza” University of Rome, Viale del Policlinico 155, 00161 Rome, ItalyDepartment of Public Health and Infectious Diseases, “ Sapienza” University of Rome, Viale del Policlinico 155, 00161 Rome, ItalyDepartment of Public Health and Infectious Diseases, “ Sapienza” University of Rome, Viale del Policlinico 155, 00161 Rome, ItalyDepartment of Public Health and Infectious Diseases, “ Sapienza” University of Rome, Viale del Policlinico 155, 00161 Rome, ItalyHIV-infected patients have a significantly greater risk of cardiovascular disease. Several markers including osteoprotegerin have been shown to be involved in the development and progression of atherosclerosis. We investigated the relationship between T-cell phenotype, osteoprotegerin, and atherosclerosis evaluated by carotid intima-media thickness (c-IMT) in 94 HIV+ patients on suppressive antiretroviral therapy with Framingham score <10%. As for the control group, 24 HIV-negative subjects were enrolled. c-IMT was assessed by ultrasound. CD4+/CD8+ T-cell activation (CD38+ HLADR+) and senescence (CD57+ CD28−) were measured by flow cytometry. IL-6 and OPG levels were measured by ELISA kit. c-IMT was higher in HIV+ than in controls. Among HIV+ patients, 44.7% had pathological c-IMT (≥0.9 mm). CD8+ T-cell activation and senescence and OPG plasma levels were higher in HIV+ patients than in controls. Subjects with pathological c-IMT exhibited higher CD8+ immune activation and immunosenescence and OPG levels than subjects with normal c-IMT. Multivariate analysis showed that age, CD8+ CD38+ HLADR+, and CD8+ CD28− CD57+ were independently associated with pathological c-IMT. Several factors have been implicated in the pathogenesis of atherosclerosis in HIV patients. Immune activation and immunosenescence of CD8+ T cell together with OPG plasma levels might be associated with the development and progression of early atherosclerosis, even in the case of viral suppression.http://dx.doi.org/10.1155/2014/192594 |
| spellingShingle | Alessandra D’Abramo Maria Antonella Zingaropoli Alessandra Oliva Claudia D’Agostino Samir Al Moghazi Giulia De Luca Marco Iannetta Claudio Maria Mastroianni Vincenzo Vullo Immune Activation, Immunosenescence, and Osteoprotegerin as Markers of Endothelial Dysfunction in Subclinical HIV-Associated Atherosclerosis Mediators of Inflammation |
| title | Immune Activation, Immunosenescence, and Osteoprotegerin as Markers of Endothelial Dysfunction in Subclinical HIV-Associated Atherosclerosis |
| title_full | Immune Activation, Immunosenescence, and Osteoprotegerin as Markers of Endothelial Dysfunction in Subclinical HIV-Associated Atherosclerosis |
| title_fullStr | Immune Activation, Immunosenescence, and Osteoprotegerin as Markers of Endothelial Dysfunction in Subclinical HIV-Associated Atherosclerosis |
| title_full_unstemmed | Immune Activation, Immunosenescence, and Osteoprotegerin as Markers of Endothelial Dysfunction in Subclinical HIV-Associated Atherosclerosis |
| title_short | Immune Activation, Immunosenescence, and Osteoprotegerin as Markers of Endothelial Dysfunction in Subclinical HIV-Associated Atherosclerosis |
| title_sort | immune activation immunosenescence and osteoprotegerin as markers of endothelial dysfunction in subclinical hiv associated atherosclerosis |
| url | http://dx.doi.org/10.1155/2014/192594 |
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