The clinical value and most informative threshold of polygenic risk score in the Quebec City Case-Control Asthma Cohort

The clinical value and most informative threshold of polygenic risk score in the Quebec City Case-Control Asthma Cohort

Abstract Genome-wide association studies (GWAS) have identified genetic variants robustly associated with asthma. A potential near-term clinical application is to calculate polygenic risk score (PRS) to improve disease risk prediction. The value of PRS, as part of numerous multi-source variables use...

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Bibliographic Details
Main Authors: Martin Pariès, Stéphanie Bougeard, Aida Eslami, Zhonglin Li, Michel Laviolette, Louis-Philippe Boulet, Evelyne Vigneau, Yohan Bossé
Format: Article
Language:English
Published: BMC 2025-01-01
Series:BMC Pulmonary Medicine
Subjects:
Asthma
Threshold
Polygenic risk score
Multivariate method
Optimal scaling
Cohort study
Online Access:https://doi.org/10.1186/s12890-025-03486-3
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