Inflammatory Serum Biomarkers in Colorectal Cancer in Kazakhstan Population
Colorectal cancer is a type of oncopathology widespread in Kazakhstan. The genetic component, as well as the possible etiopathogenetic mechanisms, is widely studied. One of the most promising areas is the study of diagnostic and prognostic possibilities of inflammatory biomarkers in patients with di...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-01-01
|
| Series: | International Journal of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2020/9476326 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832546933100511232 |
|---|---|
| author | L. Akhmaltdinova V. Sirota V. Zhumaliyeva D. Babenko I. Kadyrova Z. Tauesheva D. Taizhanova A. Ibraeva M. Maratkyzy A. Turmukhambetova |
| author_facet | L. Akhmaltdinova V. Sirota V. Zhumaliyeva D. Babenko I. Kadyrova Z. Tauesheva D. Taizhanova A. Ibraeva M. Maratkyzy A. Turmukhambetova |
| author_sort | L. Akhmaltdinova |
| collection | DOAJ |
| description | Colorectal cancer is a type of oncopathology widespread in Kazakhstan. The genetic component, as well as the possible etiopathogenetic mechanisms, is widely studied. One of the most promising areas is the study of diagnostic and prognostic possibilities of inflammatory biomarkers in patients with different degrees of tumor differentiation. The following biomarkers were included in the study panel: stem cell factor (SCF), vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF2), interleukin 6 (IL6), interleukin 8 (IL8), macrophage migration inhibitory factor (MIF), soluble Fas (SFAS), soluble Fas ligand (sFASL), transforming growth factor β (TGF), tumor necrosis factor (TNF), TNF-related apoptosis-inducing ligand (TRAIL), and programmed death ligand 1 (PD-L1). The data of our study show that most of the basic proinflammatory cytokines are involved in the systemic process and their levels do not depend on the level of tissue differentiation. Serum PD-L1 has shown itself to be a promising marker for tumor growth, which depends on the degree of differentiation. |
| format | Article |
| id | doaj-art-3836a86b3bd245bd930fb9396c5522d1 |
| institution | Kabale University |
| issn | 2090-8040 2042-0099 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Inflammation |
| spelling | doaj-art-3836a86b3bd245bd930fb9396c5522d12025-02-03T06:46:38ZengWileyInternational Journal of Inflammation2090-80402042-00992020-01-01202010.1155/2020/94763269476326Inflammatory Serum Biomarkers in Colorectal Cancer in Kazakhstan PopulationL. Akhmaltdinova0V. Sirota1V. Zhumaliyeva2D. Babenko3I. Kadyrova4Z. Tauesheva5D. Taizhanova6A. Ibraeva7M. Maratkyzy8A. Turmukhambetova9Shared Resource Lab of the Karaganda Medical University, Karaganda 10001, KazakhstanOncology Department of the Karaganda Medical University, Karaganda 10001, KazakhstanOncology Department of the Karaganda Medical University, Karaganda 10001, KazakhstanShared Resource Lab of the Karaganda Medical University, Karaganda 10001, KazakhstanShared Resource Lab of the Karaganda Medical University, Karaganda 10001, KazakhstanDepartment of Internal Diseases of the Karaganda Medical University, Karaganda 10001, KazakhstanDepartment of Internal Diseases of the Karaganda Medical University, Karaganda 10001, KazakhstanShared Resource Lab of the Karaganda Medical University, Karaganda 10001, KazakhstanShared Resource Lab of the Karaganda Medical University, Karaganda 10001, KazakhstanScience and Strategic Development Department of the Karaganda Medical University, Karaganda 10001, KazakhstanColorectal cancer is a type of oncopathology widespread in Kazakhstan. The genetic component, as well as the possible etiopathogenetic mechanisms, is widely studied. One of the most promising areas is the study of diagnostic and prognostic possibilities of inflammatory biomarkers in patients with different degrees of tumor differentiation. The following biomarkers were included in the study panel: stem cell factor (SCF), vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF2), interleukin 6 (IL6), interleukin 8 (IL8), macrophage migration inhibitory factor (MIF), soluble Fas (SFAS), soluble Fas ligand (sFASL), transforming growth factor β (TGF), tumor necrosis factor (TNF), TNF-related apoptosis-inducing ligand (TRAIL), and programmed death ligand 1 (PD-L1). The data of our study show that most of the basic proinflammatory cytokines are involved in the systemic process and their levels do not depend on the level of tissue differentiation. Serum PD-L1 has shown itself to be a promising marker for tumor growth, which depends on the degree of differentiation.http://dx.doi.org/10.1155/2020/9476326 |
| spellingShingle | L. Akhmaltdinova V. Sirota V. Zhumaliyeva D. Babenko I. Kadyrova Z. Tauesheva D. Taizhanova A. Ibraeva M. Maratkyzy A. Turmukhambetova Inflammatory Serum Biomarkers in Colorectal Cancer in Kazakhstan Population International Journal of Inflammation |
| title | Inflammatory Serum Biomarkers in Colorectal Cancer in Kazakhstan Population |
| title_full | Inflammatory Serum Biomarkers in Colorectal Cancer in Kazakhstan Population |
| title_fullStr | Inflammatory Serum Biomarkers in Colorectal Cancer in Kazakhstan Population |
| title_full_unstemmed | Inflammatory Serum Biomarkers in Colorectal Cancer in Kazakhstan Population |
| title_short | Inflammatory Serum Biomarkers in Colorectal Cancer in Kazakhstan Population |
| title_sort | inflammatory serum biomarkers in colorectal cancer in kazakhstan population |
| url | http://dx.doi.org/10.1155/2020/9476326 |
| work_keys_str_mv | AT lakhmaltdinova inflammatoryserumbiomarkersincolorectalcancerinkazakhstanpopulation AT vsirota inflammatoryserumbiomarkersincolorectalcancerinkazakhstanpopulation AT vzhumaliyeva inflammatoryserumbiomarkersincolorectalcancerinkazakhstanpopulation AT dbabenko inflammatoryserumbiomarkersincolorectalcancerinkazakhstanpopulation AT ikadyrova inflammatoryserumbiomarkersincolorectalcancerinkazakhstanpopulation AT ztauesheva inflammatoryserumbiomarkersincolorectalcancerinkazakhstanpopulation AT dtaizhanova inflammatoryserumbiomarkersincolorectalcancerinkazakhstanpopulation AT aibraeva inflammatoryserumbiomarkersincolorectalcancerinkazakhstanpopulation AT mmaratkyzy inflammatoryserumbiomarkersincolorectalcancerinkazakhstanpopulation AT aturmukhambetova inflammatoryserumbiomarkersincolorectalcancerinkazakhstanpopulation |