Sucrose-preferring gut microbes prevent host obesity by producing exopolysaccharides
Abstract Commensal bacteria affect host health by producing various metabolites from dietary carbohydrates via bacterial glycometabolism; however, the underlying mechanism of action remains unclear. Here, we identified Streptococcus salivarius as a unique anti-obesity commensal bacterium. We found t...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-01-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-025-56470-0 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832571504656646144 |
|---|---|
| author | Hidenori Shimizu Junki Miyamoto Keiko Hisa Ryuji Ohue-Kitano Hiromi Takada Mayu Yamano Akari Nishida Daiki Sasahara Yuki Masujima Keita Watanabe Shota Nishikawa Sakura Takahashi Takako Ikeda Yuya Nakajima Naofumi Yoshida Chiaki Matsuzaki Takuya Kageyama Ibuki Hayashi Akari Matsuki Ryo Akashi Seiichi Kitahama Masako Ueyama Takumi Murakami Shinsuke Inuki Junichiro Irie Noriko Satoh-Asahara Hirokazu Toju Hiroshi Mori Shinji Nakaoka Tomoya Yamashita Atsushi Toyoda Kenji Yamamoto Hiroaki Ohno Takane Katayama Hiroshi Itoh Ikuo Kimura |
| author_facet | Hidenori Shimizu Junki Miyamoto Keiko Hisa Ryuji Ohue-Kitano Hiromi Takada Mayu Yamano Akari Nishida Daiki Sasahara Yuki Masujima Keita Watanabe Shota Nishikawa Sakura Takahashi Takako Ikeda Yuya Nakajima Naofumi Yoshida Chiaki Matsuzaki Takuya Kageyama Ibuki Hayashi Akari Matsuki Ryo Akashi Seiichi Kitahama Masako Ueyama Takumi Murakami Shinsuke Inuki Junichiro Irie Noriko Satoh-Asahara Hirokazu Toju Hiroshi Mori Shinji Nakaoka Tomoya Yamashita Atsushi Toyoda Kenji Yamamoto Hiroaki Ohno Takane Katayama Hiroshi Itoh Ikuo Kimura |
| author_sort | Hidenori Shimizu |
| collection | DOAJ |
| description | Abstract Commensal bacteria affect host health by producing various metabolites from dietary carbohydrates via bacterial glycometabolism; however, the underlying mechanism of action remains unclear. Here, we identified Streptococcus salivarius as a unique anti-obesity commensal bacterium. We found that S. salivarius may prevent host obesity caused by excess sucrose intake via the exopolysaccharide (EPS) –short-chain fatty acid (SCFA) –carbohydrate metabolic axis in male mice. Healthy human donor-derived S. salivarius produced high EPS levels from sucrose but not from other sugars. S. salivarius abundance was significantly decreased in human donors with obesity compared with that in healthy donors, and the EPS–SCFA bacterial carbohydrate metabolic process was attenuated. Our findings reveal an important mechanism by which host–commensal interactions in glycometabolism affect energy regulation, suggesting an approach for preventing lifestyle-related diseases via prebiotics and probiotics by targeting bacteria and EPS metabolites. |
| format | Article |
| id | doaj-art-382d9b1b3bdf494da379bf22b9a66692 |
| institution | Kabale University |
| issn | 2041-1723 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-382d9b1b3bdf494da379bf22b9a666922025-02-02T12:32:55ZengNature PortfolioNature Communications2041-17232025-01-0116111610.1038/s41467-025-56470-0Sucrose-preferring gut microbes prevent host obesity by producing exopolysaccharidesHidenori Shimizu0Junki Miyamoto1Keiko Hisa2Ryuji Ohue-Kitano3Hiromi Takada4Mayu Yamano5Akari Nishida6Daiki Sasahara7Yuki Masujima8Keita Watanabe9Shota Nishikawa10Sakura Takahashi11Takako Ikeda12Yuya Nakajima13Naofumi Yoshida14Chiaki Matsuzaki15Takuya Kageyama16Ibuki Hayashi17Akari Matsuki18Ryo Akashi19Seiichi Kitahama20Masako Ueyama21Takumi Murakami22Shinsuke Inuki23Junichiro Irie24Noriko Satoh-Asahara25Hirokazu Toju26Hiroshi Mori27Shinji Nakaoka28Tomoya Yamashita29Atsushi Toyoda30Kenji Yamamoto31Hiroaki Ohno32Takane Katayama33Hiroshi Itoh34Ikuo Kimura35Laboratory of Molecular Neurobiology, Graduate School of Biostudies, Kyoto University, Sakyo-kuDepartment of Applied Biological Science, Graduate School of Agriculture, Tokyo University of Agriculture and TechnologyNoster Inc., Kamiueno, Muko-shiLaboratory of Molecular Neurobiology, Graduate School of Biostudies, Kyoto University, Sakyo-kuLaboratory of Molecular Neurobiology, Graduate School of Biostudies, Kyoto University, Sakyo-kuDepartment of Molecular Endocrinology, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-kuDepartment of Molecular Endocrinology, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-kuLaboratory of Molecular Neurobiology, Graduate School of Biostudies, Kyoto University, Sakyo-kuLaboratory of Molecular Neurobiology, Graduate School of Biostudies, Kyoto University, Sakyo-kuLaboratory of Molecular Neurobiology, Graduate School of Biostudies, Kyoto University, Sakyo-kuDepartment of Molecular Endocrinology, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-kuLaboratory of Molecular Neurobiology, Graduate School of Biostudies, Kyoto University, Sakyo-kuLaboratory of Molecular Neurobiology, Graduate School of Biostudies, Kyoto University, Sakyo-kuDepartment of Endocrinology, Metabolism and Nephrology, School of Medicine, Keio University, Shinjuku-kuDepartment of Advanced Medical Technologies, National Cerebral and Cardiovascular Center Research InstituteResearch Institute for Bioresources and Biotechnology, Ishikawa Prefectural UniversityCenter for Ecological Research, Kyoto UniversityLaboratory of Ecosystems and Coevolution, Graduate School of Biostudies, Kyoto UniversityLaboratory of Mathematical Biology, Faculty of Advanced Life Science, Hokkaido UniversityLaboratory of Mathematical Biology, Faculty of Advanced Life Science, Hokkaido UniversityDepartment of Metabolic and Bariatric Surgery, Center for Obesity, Diabetes and Endocrinology, Chibune General HospitalSleep Apnea Syndrome Treatment Center, Fukujuji Hospital, Japan Anti-Tuberculosis AssociationAdvanced Genomics Center, National Institute of Genetics, YataDepartment of Bioorganic Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-kuDepartment of Endocrinology, Metabolism and Nephrology, School of Medicine, Keio University, Shinjuku-kuDepartment of Endocrinology, Metabolism, and Hypertension Research, Clinical Research Institute, NHO Kyoto Medical CenterLaboratory of Ecosystems and Coevolution, Graduate School of Biostudies, Kyoto UniversityAdvanced Genomics Center, National Institute of Genetics, YataLaboratory of Mathematical Biology, Faculty of Advanced Life Science, Hokkaido UniversityDivision of Advanced Medical Science, Graduate School of Science, Technology and Innovation, Kobe UniversityAdvanced Genomics Center, National Institute of Genetics, YataCenter for Innovative and Joint Research, Wakayama University, Wakayama-shiDepartment of Bioorganic Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-kuLaboratory of Molecular Biology and Bioresponse, Graduate School of Biostudies, Kyoto University, Sakyo-kuDepartment of Endocrinology, Metabolism and Nephrology, School of Medicine, Keio University, Shinjuku-kuLaboratory of Molecular Neurobiology, Graduate School of Biostudies, Kyoto University, Sakyo-kuAbstract Commensal bacteria affect host health by producing various metabolites from dietary carbohydrates via bacterial glycometabolism; however, the underlying mechanism of action remains unclear. Here, we identified Streptococcus salivarius as a unique anti-obesity commensal bacterium. We found that S. salivarius may prevent host obesity caused by excess sucrose intake via the exopolysaccharide (EPS) –short-chain fatty acid (SCFA) –carbohydrate metabolic axis in male mice. Healthy human donor-derived S. salivarius produced high EPS levels from sucrose but not from other sugars. S. salivarius abundance was significantly decreased in human donors with obesity compared with that in healthy donors, and the EPS–SCFA bacterial carbohydrate metabolic process was attenuated. Our findings reveal an important mechanism by which host–commensal interactions in glycometabolism affect energy regulation, suggesting an approach for preventing lifestyle-related diseases via prebiotics and probiotics by targeting bacteria and EPS metabolites.https://doi.org/10.1038/s41467-025-56470-0 |
| spellingShingle | Hidenori Shimizu Junki Miyamoto Keiko Hisa Ryuji Ohue-Kitano Hiromi Takada Mayu Yamano Akari Nishida Daiki Sasahara Yuki Masujima Keita Watanabe Shota Nishikawa Sakura Takahashi Takako Ikeda Yuya Nakajima Naofumi Yoshida Chiaki Matsuzaki Takuya Kageyama Ibuki Hayashi Akari Matsuki Ryo Akashi Seiichi Kitahama Masako Ueyama Takumi Murakami Shinsuke Inuki Junichiro Irie Noriko Satoh-Asahara Hirokazu Toju Hiroshi Mori Shinji Nakaoka Tomoya Yamashita Atsushi Toyoda Kenji Yamamoto Hiroaki Ohno Takane Katayama Hiroshi Itoh Ikuo Kimura Sucrose-preferring gut microbes prevent host obesity by producing exopolysaccharides Nature Communications |
| title | Sucrose-preferring gut microbes prevent host obesity by producing exopolysaccharides |
| title_full | Sucrose-preferring gut microbes prevent host obesity by producing exopolysaccharides |
| title_fullStr | Sucrose-preferring gut microbes prevent host obesity by producing exopolysaccharides |
| title_full_unstemmed | Sucrose-preferring gut microbes prevent host obesity by producing exopolysaccharides |
| title_short | Sucrose-preferring gut microbes prevent host obesity by producing exopolysaccharides |
| title_sort | sucrose preferring gut microbes prevent host obesity by producing exopolysaccharides |
| url | https://doi.org/10.1038/s41467-025-56470-0 |
| work_keys_str_mv | AT hidenorishimizu sucrosepreferringgutmicrobespreventhostobesitybyproducingexopolysaccharides AT junkimiyamoto sucrosepreferringgutmicrobespreventhostobesitybyproducingexopolysaccharides AT keikohisa sucrosepreferringgutmicrobespreventhostobesitybyproducingexopolysaccharides AT ryujiohuekitano sucrosepreferringgutmicrobespreventhostobesitybyproducingexopolysaccharides AT hiromitakada sucrosepreferringgutmicrobespreventhostobesitybyproducingexopolysaccharides AT mayuyamano sucrosepreferringgutmicrobespreventhostobesitybyproducingexopolysaccharides AT akarinishida sucrosepreferringgutmicrobespreventhostobesitybyproducingexopolysaccharides AT daikisasahara sucrosepreferringgutmicrobespreventhostobesitybyproducingexopolysaccharides AT yukimasujima sucrosepreferringgutmicrobespreventhostobesitybyproducingexopolysaccharides AT keitawatanabe sucrosepreferringgutmicrobespreventhostobesitybyproducingexopolysaccharides AT shotanishikawa sucrosepreferringgutmicrobespreventhostobesitybyproducingexopolysaccharides AT sakuratakahashi sucrosepreferringgutmicrobespreventhostobesitybyproducingexopolysaccharides AT takakoikeda sucrosepreferringgutmicrobespreventhostobesitybyproducingexopolysaccharides AT yuyanakajima sucrosepreferringgutmicrobespreventhostobesitybyproducingexopolysaccharides AT naofumiyoshida sucrosepreferringgutmicrobespreventhostobesitybyproducingexopolysaccharides AT chiakimatsuzaki sucrosepreferringgutmicrobespreventhostobesitybyproducingexopolysaccharides AT takuyakageyama sucrosepreferringgutmicrobespreventhostobesitybyproducingexopolysaccharides AT ibukihayashi sucrosepreferringgutmicrobespreventhostobesitybyproducingexopolysaccharides AT akarimatsuki sucrosepreferringgutmicrobespreventhostobesitybyproducingexopolysaccharides AT ryoakashi sucrosepreferringgutmicrobespreventhostobesitybyproducingexopolysaccharides AT seiichikitahama sucrosepreferringgutmicrobespreventhostobesitybyproducingexopolysaccharides AT masakoueyama sucrosepreferringgutmicrobespreventhostobesitybyproducingexopolysaccharides AT takumimurakami sucrosepreferringgutmicrobespreventhostobesitybyproducingexopolysaccharides AT shinsukeinuki sucrosepreferringgutmicrobespreventhostobesitybyproducingexopolysaccharides AT junichiroirie sucrosepreferringgutmicrobespreventhostobesitybyproducingexopolysaccharides AT norikosatohasahara sucrosepreferringgutmicrobespreventhostobesitybyproducingexopolysaccharides AT hirokazutoju sucrosepreferringgutmicrobespreventhostobesitybyproducingexopolysaccharides AT hiroshimori sucrosepreferringgutmicrobespreventhostobesitybyproducingexopolysaccharides AT shinjinakaoka sucrosepreferringgutmicrobespreventhostobesitybyproducingexopolysaccharides AT tomoyayamashita sucrosepreferringgutmicrobespreventhostobesitybyproducingexopolysaccharides AT atsushitoyoda sucrosepreferringgutmicrobespreventhostobesitybyproducingexopolysaccharides AT kenjiyamamoto sucrosepreferringgutmicrobespreventhostobesitybyproducingexopolysaccharides AT hiroakiohno sucrosepreferringgutmicrobespreventhostobesitybyproducingexopolysaccharides AT takanekatayama sucrosepreferringgutmicrobespreventhostobesitybyproducingexopolysaccharides AT hiroshiitoh sucrosepreferringgutmicrobespreventhostobesitybyproducingexopolysaccharides AT ikuokimura sucrosepreferringgutmicrobespreventhostobesitybyproducingexopolysaccharides |