Prevalence of Oral Manifestations and Their Association with CD4/CD8 Ratio and HIV Viral Load in South India
The objective of the present research was to determine the prevalence of oral manifestations in an HIV infected population from south India and evaluate their association with HIV viral load and CD4/CD8 ratio. Intraoral examination of 103 patients, whose CD4/CD8 ratio was available, were conducted....
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | International Journal of Dentistry |
| Online Access: | http://dx.doi.org/10.1155/2011/964278 |
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| author | Sharma Gaurav Pai M. Keerthilatha Nagpal Archna |
| author_facet | Sharma Gaurav Pai M. Keerthilatha Nagpal Archna |
| author_sort | Sharma Gaurav |
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| description | The objective of the present research was to determine the prevalence of oral manifestations in an HIV infected population from south India and evaluate their association with HIV viral load and CD4/CD8 ratio. Intraoral examination of 103 patients, whose CD4/CD8 ratio was available, were conducted. HIV viral loads were available for thirty patients only. The prevalence of oral manifestations was 80.6% (83/103). The most common oromucosal lesion was erythematous candidiasis (EC) (38.8%) followed by melanotic hyperpigmentation (35.9%). Patients having any oral manifestation had a mean CD4/CD8 ratio of 0.24. EC had positive predictive value of 85.0% for CD4/CD8 ratio <0.30. The prevalence of oral manifestations in patients taking ART was lesser (78.6%) as compared to patients not taking ART (82%). Patients having any oral manifestation had a higher HIV viral load as compared to patients not having any oral manifestations (𝑃<0.05). Pseudomembranous candidiasis (PC) was significantly associated with higher HIV viral loads (>20,000 copies/mL) (𝑃<0.05). Patients having EC had 4 times greater chance of having CD4/CD8 ratio <0.30. PC can be considered as a marker of immune suppression (HIV viral load >20,000 copies/mL). |
| format | Article |
| id | doaj-art-382a2dab19f146c8989c1a5055afd4f3 |
| institution | Kabale University |
| issn | 1687-8728 1687-8736 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Dentistry |
| spelling | doaj-art-382a2dab19f146c8989c1a5055afd4f32025-02-03T05:58:03ZengWileyInternational Journal of Dentistry1687-87281687-87362011-01-01201110.1155/2011/964278964278Prevalence of Oral Manifestations and Their Association with CD4/CD8 Ratio and HIV Viral Load in South IndiaSharma Gaurav0Pai M. Keerthilatha1Nagpal Archna2Department of Oral Medicine and Radiology, Sudha Rustagi Dental College, Haryana, Faridabad 121002, IndiaDepartment of Oral Medicine and Radiology, Manipal College of Dental Sciences, Manipal 576104, IndiaDepartment of Oral Medicine and Radiology, PDM Dental College, Haryana, Bahadurgarh 124507, IndiaThe objective of the present research was to determine the prevalence of oral manifestations in an HIV infected population from south India and evaluate their association with HIV viral load and CD4/CD8 ratio. Intraoral examination of 103 patients, whose CD4/CD8 ratio was available, were conducted. HIV viral loads were available for thirty patients only. The prevalence of oral manifestations was 80.6% (83/103). The most common oromucosal lesion was erythematous candidiasis (EC) (38.8%) followed by melanotic hyperpigmentation (35.9%). Patients having any oral manifestation had a mean CD4/CD8 ratio of 0.24. EC had positive predictive value of 85.0% for CD4/CD8 ratio <0.30. The prevalence of oral manifestations in patients taking ART was lesser (78.6%) as compared to patients not taking ART (82%). Patients having any oral manifestation had a higher HIV viral load as compared to patients not having any oral manifestations (𝑃<0.05). Pseudomembranous candidiasis (PC) was significantly associated with higher HIV viral loads (>20,000 copies/mL) (𝑃<0.05). Patients having EC had 4 times greater chance of having CD4/CD8 ratio <0.30. PC can be considered as a marker of immune suppression (HIV viral load >20,000 copies/mL).http://dx.doi.org/10.1155/2011/964278 |
| spellingShingle | Sharma Gaurav Pai M. Keerthilatha Nagpal Archna Prevalence of Oral Manifestations and Their Association with CD4/CD8 Ratio and HIV Viral Load in South India International Journal of Dentistry |
| title | Prevalence of Oral Manifestations and Their Association with CD4/CD8 Ratio and HIV Viral Load in South India |
| title_full | Prevalence of Oral Manifestations and Their Association with CD4/CD8 Ratio and HIV Viral Load in South India |
| title_fullStr | Prevalence of Oral Manifestations and Their Association with CD4/CD8 Ratio and HIV Viral Load in South India |
| title_full_unstemmed | Prevalence of Oral Manifestations and Their Association with CD4/CD8 Ratio and HIV Viral Load in South India |
| title_short | Prevalence of Oral Manifestations and Their Association with CD4/CD8 Ratio and HIV Viral Load in South India |
| title_sort | prevalence of oral manifestations and their association with cd4 cd8 ratio and hiv viral load in south india |
| url | http://dx.doi.org/10.1155/2011/964278 |
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