Oral Lesion as Unusual First Manifestation of Multiple Myeloma: Case Reports and Review of the Literature
Extramedullary plasmacytoma (EMP) and solitary bone plasmacytoma (SBP) represent a disease continuum through a multistage process of cell differentiation, survival, proliferation, and dissemination, strictly related to multiple myeloma (MM), the second most common hematological malignancy. Herein, w...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2014/529452 |
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| author | A. Romano M. S. Marescalco Chiara Liardo L. Villari C. Vetro C. Conticello F. Di Raimondo S. Ferlito |
| author_facet | A. Romano M. S. Marescalco Chiara Liardo L. Villari C. Vetro C. Conticello F. Di Raimondo S. Ferlito |
| author_sort | A. Romano |
| collection | DOAJ |
| description | Extramedullary plasmacytoma (EMP) and solitary bone plasmacytoma (SBP) represent a disease continuum through a multistage process of cell differentiation, survival, proliferation, and dissemination, strictly related to multiple myeloma (MM), the second most common hematological malignancy. Herein, we report two cases of recurrent oral plasmacytoma progressed to MM, in which the first clinical sign of a more widespread disease was limited to the mouth. Based on our experience, we recommend a strict workup for the differential diagnosis between EMP, SBP, and MM for patients with oral plasmacytoma, including radiological exam of the skeleton, magnetic resonance imaging (MRI) of the bone, and positive emission tomography (FDG-PET). MRI and possibly PET can all be used to more sensitively detect EM plasmacytoma sites. |
| format | Article |
| id | doaj-art-382880d020e24c15940e09c2dd7678e5 |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-382880d020e24c15940e09c2dd7678e52025-02-03T01:03:13ZengWileyCase Reports in Hematology2090-65602090-65792014-01-01201410.1155/2014/529452529452Oral Lesion as Unusual First Manifestation of Multiple Myeloma: Case Reports and Review of the LiteratureA. Romano0M. S. Marescalco1Chiara Liardo2L. Villari3C. Vetro4C. Conticello5F. Di Raimondo6S. Ferlito7Department of Clinical and Molecular Biomedicine, Section of Haematology, University of Catania, Via Citelli 6, 95124 Catania, ItalyDepartment of Clinical and Molecular Biomedicine, Section of Haematology, University of Catania, Via Citelli 6, 95124 Catania, Italy1st Section of Dentistry, Department of Surgery, University of Catania, Via Citelli 6, 95124 Catania, ItalyDivision of Pathology, AOU “Policlinico-Vittorio Emanuele”, Via Plebiscito 628, 95100 Catania, ItalyDepartment of Clinical and Molecular Biomedicine, Section of Haematology, University of Catania, Via Citelli 6, 95124 Catania, ItalyDepartment of Clinical and Molecular Biomedicine, Section of Haematology, University of Catania, Via Citelli 6, 95124 Catania, ItalyDepartment of Clinical and Molecular Biomedicine, Section of Haematology, University of Catania, Via Citelli 6, 95124 Catania, Italy1st Section of Dentistry, Department of Surgery, University of Catania, Via Citelli 6, 95124 Catania, ItalyExtramedullary plasmacytoma (EMP) and solitary bone plasmacytoma (SBP) represent a disease continuum through a multistage process of cell differentiation, survival, proliferation, and dissemination, strictly related to multiple myeloma (MM), the second most common hematological malignancy. Herein, we report two cases of recurrent oral plasmacytoma progressed to MM, in which the first clinical sign of a more widespread disease was limited to the mouth. Based on our experience, we recommend a strict workup for the differential diagnosis between EMP, SBP, and MM for patients with oral plasmacytoma, including radiological exam of the skeleton, magnetic resonance imaging (MRI) of the bone, and positive emission tomography (FDG-PET). MRI and possibly PET can all be used to more sensitively detect EM plasmacytoma sites.http://dx.doi.org/10.1155/2014/529452 |
| spellingShingle | A. Romano M. S. Marescalco Chiara Liardo L. Villari C. Vetro C. Conticello F. Di Raimondo S. Ferlito Oral Lesion as Unusual First Manifestation of Multiple Myeloma: Case Reports and Review of the Literature Case Reports in Hematology |
| title | Oral Lesion as Unusual First Manifestation of Multiple Myeloma: Case Reports and Review of the Literature |
| title_full | Oral Lesion as Unusual First Manifestation of Multiple Myeloma: Case Reports and Review of the Literature |
| title_fullStr | Oral Lesion as Unusual First Manifestation of Multiple Myeloma: Case Reports and Review of the Literature |
| title_full_unstemmed | Oral Lesion as Unusual First Manifestation of Multiple Myeloma: Case Reports and Review of the Literature |
| title_short | Oral Lesion as Unusual First Manifestation of Multiple Myeloma: Case Reports and Review of the Literature |
| title_sort | oral lesion as unusual first manifestation of multiple myeloma case reports and review of the literature |
| url | http://dx.doi.org/10.1155/2014/529452 |
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