Pirfenidone regulates seizures through the HMGB1/TLR4 axis to improve cognitive functions and modulate oxidative stress and neurotransmitters in PTZ-induced kindling in mice

Pirfenidone regulates seizures through the HMGB1/TLR4 axis to improve cognitive functions and modulate oxidative stress and neurotransmitters in PTZ-induced kindling in mice

BackgroundEpilepsy is a neurological disorder characterized by recurrent seizures due to abnormal electrical activity in the brain. Pirfenidone, an antifibrotic drug, has shown anti-inflammatory and antioxidant properties in various disease models, including neurological conditions. However, its pot...

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Bibliographic Details
Main Authors: Mansi Dahalia, Sparsh Gupta, Haya Majid, Divya Vohora, Nidhi
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Pharmacology
Subjects:
anticonvulsant
cognition
epilepsy
neuroinflammation
neurotransmitters
pentylenetetrazole
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1528032/full
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