Glucocorticoid-Induced TNFR-Related (GITR) Protein and Its Ligand in Antitumor Immunity: Functional Role and Therapeutic Modulation
The ability of the tumor necrosis factor receptor (TNFR) family member GITR to modulate immune responses has been the subject of multiple studies. Initially thought to be critically involved in governing functions of regulatory T cells, GITR and its ligand GITRL have meanwhile been found to modulate...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2010-01-01
|
| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2010/239083 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832564398320779264 |
|---|---|
| author | Theresa Placke Hans-Georg Kopp Helmut Rainer Salih |
| author_facet | Theresa Placke Hans-Georg Kopp Helmut Rainer Salih |
| author_sort | Theresa Placke |
| collection | DOAJ |
| description | The ability of the tumor necrosis factor receptor (TNFR) family member GITR to modulate immune responses has been the subject of multiple studies. Initially thought to be critically involved in governing functions of regulatory T cells, GITR and its ligand GITRL have meanwhile been found to modulate the reactivity of various different cell types and to influence a broad variety of immunological conditions including the immune response against tumors. Not only GITR, but also GITRL is capable of transducing signals, and the consequences of GITR-GITRL interaction may vary among different effector cell types, differ upon signal transduction via the receptor, the ligand, or both, depend on the level of an ongoing immune response, and even differ among mice and men. In this paper, we address available data on GITR and its ligand in immune responses and discuss the role and potential therapeutic modulation of this molecule system in antitumor immunity. |
| format | Article |
| id | doaj-art-381442bc9b6a43ea8976eebe2b9f3ff0 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-381442bc9b6a43ea8976eebe2b9f3ff02025-02-03T01:11:01ZengWileyClinical and Developmental Immunology1740-25221740-25302010-01-01201010.1155/2010/239083239083Glucocorticoid-Induced TNFR-Related (GITR) Protein and Its Ligand in Antitumor Immunity: Functional Role and Therapeutic ModulationTheresa Placke0Hans-Georg Kopp1Helmut Rainer Salih2Department of Hematology/Oncology, Eberhard Karls University, Otfried-Mueller-Str. 10, 72076 Tuebingen, GermanyDepartment of Hematology/Oncology, Eberhard Karls University, Otfried-Mueller-Str. 10, 72076 Tuebingen, GermanyDepartment of Hematology/Oncology, Eberhard Karls University, Otfried-Mueller-Str. 10, 72076 Tuebingen, GermanyThe ability of the tumor necrosis factor receptor (TNFR) family member GITR to modulate immune responses has been the subject of multiple studies. Initially thought to be critically involved in governing functions of regulatory T cells, GITR and its ligand GITRL have meanwhile been found to modulate the reactivity of various different cell types and to influence a broad variety of immunological conditions including the immune response against tumors. Not only GITR, but also GITRL is capable of transducing signals, and the consequences of GITR-GITRL interaction may vary among different effector cell types, differ upon signal transduction via the receptor, the ligand, or both, depend on the level of an ongoing immune response, and even differ among mice and men. In this paper, we address available data on GITR and its ligand in immune responses and discuss the role and potential therapeutic modulation of this molecule system in antitumor immunity.http://dx.doi.org/10.1155/2010/239083 |
| spellingShingle | Theresa Placke Hans-Georg Kopp Helmut Rainer Salih Glucocorticoid-Induced TNFR-Related (GITR) Protein and Its Ligand in Antitumor Immunity: Functional Role and Therapeutic Modulation Clinical and Developmental Immunology |
| title | Glucocorticoid-Induced TNFR-Related (GITR) Protein and Its Ligand in Antitumor Immunity: Functional Role and Therapeutic Modulation |
| title_full | Glucocorticoid-Induced TNFR-Related (GITR) Protein and Its Ligand in Antitumor Immunity: Functional Role and Therapeutic Modulation |
| title_fullStr | Glucocorticoid-Induced TNFR-Related (GITR) Protein and Its Ligand in Antitumor Immunity: Functional Role and Therapeutic Modulation |
| title_full_unstemmed | Glucocorticoid-Induced TNFR-Related (GITR) Protein and Its Ligand in Antitumor Immunity: Functional Role and Therapeutic Modulation |
| title_short | Glucocorticoid-Induced TNFR-Related (GITR) Protein and Its Ligand in Antitumor Immunity: Functional Role and Therapeutic Modulation |
| title_sort | glucocorticoid induced tnfr related gitr protein and its ligand in antitumor immunity functional role and therapeutic modulation |
| url | http://dx.doi.org/10.1155/2010/239083 |
| work_keys_str_mv | AT theresaplacke glucocorticoidinducedtnfrrelatedgitrproteinanditsligandinantitumorimmunityfunctionalroleandtherapeuticmodulation AT hansgeorgkopp glucocorticoidinducedtnfrrelatedgitrproteinanditsligandinantitumorimmunityfunctionalroleandtherapeuticmodulation AT helmutrainersalih glucocorticoidinducedtnfrrelatedgitrproteinanditsligandinantitumorimmunityfunctionalroleandtherapeuticmodulation |