Ovarian Volume Correlates Strongly with the Number of Nongrowing Follicles in the Human Ovary

A reliable indirect measure of ovarian reserve for the individual woman remains a challenge for reproductive specialists. Using descriptive statistics from a large-scale study of ovarian volumes, we have developed a normative model for healthy females for ages 25 through 85. For average values, this...

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Bibliographic Details
Main Authors: Thomas W. Kelsey, W. Hamish B. Wallace
Format: Article
Language:English
Published: Wiley 2012-01-01
Series:Obstetrics and Gynecology International
Online Access:http://dx.doi.org/10.1155/2012/305025
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Summary:A reliable indirect measure of ovarian reserve for the individual woman remains a challenge for reproductive specialists. Using descriptive statistics from a large-scale study of ovarian volumes, we have developed a normative model for healthy females for ages 25 through 85. For average values, this model has a strong and positive correlation (r=0.89) with our recent model of nongrowing follicles (NGFs) in the human ovary for ages 25 through 51. When both models are log-adjusted, the correlation increases to r=0.99, over the full range of ovarian volume. Furthermore we can deduce that an ovary of 3 cm3 volume (or less) contains approximately 1000 NGF (or fewer). These strong correlations indicate that ovarian volume is a useful factor in the indirect estimation of human ovarian reserve for the individual woman.
ISSN:1687-9589
1687-9597