Nano‐gold micelles loaded Dox and Elacridar for reversing drug resistance of breast cancer
Abstract The aim of this study was to provide a new effective carrier for rescuing the sensitivity of drug‐resistant in breast cancer cells. Nano‐gold micelles loaded with Dox and Elacridar (FP‐ssD@A‐E) were chemically synthesised. With the increase in the amount of Dox and Elacridar, the encapsulat...
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| Format: | Article |
| Language: | English |
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Wiley
2023-04-01
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| Series: | IET Nanobiotechnology |
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| Online Access: | https://doi.org/10.1049/nbt2.12102 |
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| author | Liu‐Jing Wen Yue‐Sheng Wang Jie Zhang |
| author_facet | Liu‐Jing Wen Yue‐Sheng Wang Jie Zhang |
| author_sort | Liu‐Jing Wen |
| collection | DOAJ |
| description | Abstract The aim of this study was to provide a new effective carrier for rescuing the sensitivity of drug‐resistant in breast cancer cells. Nano‐gold micelles loaded with Dox and Elacridar (FP‐ssD@A‐E) were chemically synthesised. With the increase in the amount of Dox and Elacridar, the encapsulation rate of FP‐ssD@A‐E gradually increased, and the drug loading rate gradually decreased. FP‐ss@A‐E had a sustained‐release effect. Dox, Elacridar, FP‐ss@AuNPs, and FP‐ssD@A‐E significantly improved cell apoptosis, in which, FP‐ssD@A‐E was the most significant. FP‐ssD@A‐E significantly decreased the cell viability and improved the Dox uptake. The levels of VEGFR‐1, P‐gp, IL‐6, and i‐NOS were significantly decreased after Dox, Dox + Elacridar, FP‐ss@AuNPs, and FP‐ssD@A‐E treatment. It was worth noting that FP‐ssD@A‐E had the most significant effects. The prepared FP‐ssD@A‐E micelles, which were spherical in shape, uniform in particle size distribution, and had good drug loading performance and encapsulation efficiency. |
| format | Article |
| id | doaj-art-37f344a0694843dfb4284ece6e85c60e |
| institution | Kabale University |
| issn | 1751-8741 1751-875X |
| language | English |
| publishDate | 2023-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | IET Nanobiotechnology |
| spelling | doaj-art-37f344a0694843dfb4284ece6e85c60e2025-02-03T06:47:34ZengWileyIET Nanobiotechnology1751-87411751-875X2023-04-01172496010.1049/nbt2.12102Nano‐gold micelles loaded Dox and Elacridar for reversing drug resistance of breast cancerLiu‐Jing Wen0Yue‐Sheng Wang1Jie Zhang2Department of Pharmacy Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and Therapy Tianjin's Clinical Research Center for Cancer Tianjin ChinaDepartment of Dentistry Second Hospital Affiliated to Tianjin Medical University Tianjin ChinaDepartment of Pharmacy Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and Therapy Tianjin's Clinical Research Center for Cancer Tianjin ChinaAbstract The aim of this study was to provide a new effective carrier for rescuing the sensitivity of drug‐resistant in breast cancer cells. Nano‐gold micelles loaded with Dox and Elacridar (FP‐ssD@A‐E) were chemically synthesised. With the increase in the amount of Dox and Elacridar, the encapsulation rate of FP‐ssD@A‐E gradually increased, and the drug loading rate gradually decreased. FP‐ss@A‐E had a sustained‐release effect. Dox, Elacridar, FP‐ss@AuNPs, and FP‐ssD@A‐E significantly improved cell apoptosis, in which, FP‐ssD@A‐E was the most significant. FP‐ssD@A‐E significantly decreased the cell viability and improved the Dox uptake. The levels of VEGFR‐1, P‐gp, IL‐6, and i‐NOS were significantly decreased after Dox, Dox + Elacridar, FP‐ss@AuNPs, and FP‐ssD@A‐E treatment. It was worth noting that FP‐ssD@A‐E had the most significant effects. The prepared FP‐ssD@A‐E micelles, which were spherical in shape, uniform in particle size distribution, and had good drug loading performance and encapsulation efficiency.https://doi.org/10.1049/nbt2.12102breast cancerdoxorubicindrug loaded hybrid micelleselacridargold nanoparticles |
| spellingShingle | Liu‐Jing Wen Yue‐Sheng Wang Jie Zhang Nano‐gold micelles loaded Dox and Elacridar for reversing drug resistance of breast cancer IET Nanobiotechnology breast cancer doxorubicin drug loaded hybrid micelles elacridar gold nanoparticles |
| title | Nano‐gold micelles loaded Dox and Elacridar for reversing drug resistance of breast cancer |
| title_full | Nano‐gold micelles loaded Dox and Elacridar for reversing drug resistance of breast cancer |
| title_fullStr | Nano‐gold micelles loaded Dox and Elacridar for reversing drug resistance of breast cancer |
| title_full_unstemmed | Nano‐gold micelles loaded Dox and Elacridar for reversing drug resistance of breast cancer |
| title_short | Nano‐gold micelles loaded Dox and Elacridar for reversing drug resistance of breast cancer |
| title_sort | nano gold micelles loaded dox and elacridar for reversing drug resistance of breast cancer |
| topic | breast cancer doxorubicin drug loaded hybrid micelles elacridar gold nanoparticles |
| url | https://doi.org/10.1049/nbt2.12102 |
| work_keys_str_mv | AT liujingwen nanogoldmicellesloadeddoxandelacridarforreversingdrugresistanceofbreastcancer AT yueshengwang nanogoldmicellesloadeddoxandelacridarforreversingdrugresistanceofbreastcancer AT jiezhang nanogoldmicellesloadeddoxandelacridarforreversingdrugresistanceofbreastcancer |