Donor Specific Anti-HLA Antibody and Risk of Graft Failure in Haploidentical Stem Cell Transplantation
Outcomes of allogeneic hematopoietic stem cell transplantation (AHSCT) using HLA-half matched related donors (haploidentical) have recently improved due to better control of alloreactive reactions in both graft-versus-host and host-versus-graft directions. The recognition of the role of humoral reje...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Advances in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2016/4025073 |
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| author | Piyanuch Kongtim Kai Cao Stefan O. Ciurea |
| author_facet | Piyanuch Kongtim Kai Cao Stefan O. Ciurea |
| author_sort | Piyanuch Kongtim |
| collection | DOAJ |
| description | Outcomes of allogeneic hematopoietic stem cell transplantation (AHSCT) using HLA-half matched related donors (haploidentical) have recently improved due to better control of alloreactive reactions in both graft-versus-host and host-versus-graft directions. The recognition of the role of humoral rejection in the development of primary graft failure in this setting has broadened our understanding about causes of engraftment failure in these patients, helped us better select donors for patients in need of AHSCT, and developed rational therapeutic measures for HLA sensitized patients to prevent this unfortunate event, which is usually associated with a very high mortality rate. With these recent advances the rate of graft failure in haploidentical transplantation has decreased to less than 5%. |
| format | Article |
| id | doaj-art-37f06ce8139a40bb8eeaac1533fd9cc1 |
| institution | Kabale University |
| issn | 1687-9104 1687-9112 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Hematology |
| spelling | doaj-art-37f06ce8139a40bb8eeaac1533fd9cc12025-02-03T00:58:56ZengWileyAdvances in Hematology1687-91041687-91122016-01-01201610.1155/2016/40250734025073Donor Specific Anti-HLA Antibody and Risk of Graft Failure in Haploidentical Stem Cell TransplantationPiyanuch Kongtim0Kai Cao1Stefan O. Ciurea2Department of Stem Cell Transplant and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USADepartment of Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USADepartment of Stem Cell Transplant and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USAOutcomes of allogeneic hematopoietic stem cell transplantation (AHSCT) using HLA-half matched related donors (haploidentical) have recently improved due to better control of alloreactive reactions in both graft-versus-host and host-versus-graft directions. The recognition of the role of humoral rejection in the development of primary graft failure in this setting has broadened our understanding about causes of engraftment failure in these patients, helped us better select donors for patients in need of AHSCT, and developed rational therapeutic measures for HLA sensitized patients to prevent this unfortunate event, which is usually associated with a very high mortality rate. With these recent advances the rate of graft failure in haploidentical transplantation has decreased to less than 5%.http://dx.doi.org/10.1155/2016/4025073 |
| spellingShingle | Piyanuch Kongtim Kai Cao Stefan O. Ciurea Donor Specific Anti-HLA Antibody and Risk of Graft Failure in Haploidentical Stem Cell Transplantation Advances in Hematology |
| title | Donor Specific Anti-HLA Antibody and Risk of Graft Failure in Haploidentical Stem Cell Transplantation |
| title_full | Donor Specific Anti-HLA Antibody and Risk of Graft Failure in Haploidentical Stem Cell Transplantation |
| title_fullStr | Donor Specific Anti-HLA Antibody and Risk of Graft Failure in Haploidentical Stem Cell Transplantation |
| title_full_unstemmed | Donor Specific Anti-HLA Antibody and Risk of Graft Failure in Haploidentical Stem Cell Transplantation |
| title_short | Donor Specific Anti-HLA Antibody and Risk of Graft Failure in Haploidentical Stem Cell Transplantation |
| title_sort | donor specific anti hla antibody and risk of graft failure in haploidentical stem cell transplantation |
| url | http://dx.doi.org/10.1155/2016/4025073 |
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