Rosa roxburghii Tratt fruit extract ameliorate free fatty acid induced steatosis in HepG2 cells through activating PI3K-Akt and PPAR pathways

Rosa roxburghii Tratt fruit extract ameliorate free fatty acid induced steatosis in HepG2 cells through activating PI3K-Akt and PPAR pathways

Abstract There has been a continuous increase in the global incidence of obesity. Rosa roxburghii Tratt (RRT), a plant with medicinal and edible uses, contains active components that can alleviate obesity, indicating an anti-obesity potential. This research sought to investigate the anti-obesity eff...

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Bibliographic Details
Main Authors: Yihan Ling, Wenxi Wang, Xingjie Li, Xiaomeng Wang, Shuwen Zhang, Shaolin Huang, Heting Zhou, Lijun Peng, Wenya Yin
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Rosa roxburghii Tratt fruit extract
Obesity
Lipid metabolism
Mitochondrial function
Network Pharmacology
PI3K-Akt signaling pathway
Online Access:https://doi.org/10.1038/s41598-025-12126-z
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