Non-Drug and Non-Invasive Therapeutic Options in Alzheimer’s Disease
Despite the massive efforts of modern medicine to stop the evolution of Alzheimer’s disease (AD), it affects an increasing number of people, changing individual lives and imposing itself as a burden on families and the health systems. Considering that the vast majority of conventional drug therapies...
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MDPI AG
2025-01-01
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| Series: | Biomedicines |
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| author | Alina Simona Șovrea Adina Bianca Boșca Eleonora Dronca Anne-Marie Constantin Andreea Crintea Rada Suflețel Roxana Adelina Ștefan Paul Andrei Ștefan Mădălin Mihai Onofrei Christoph Tschall Carmen-Bianca Crivii |
| author_facet | Alina Simona Șovrea Adina Bianca Boșca Eleonora Dronca Anne-Marie Constantin Andreea Crintea Rada Suflețel Roxana Adelina Ștefan Paul Andrei Ștefan Mădălin Mihai Onofrei Christoph Tschall Carmen-Bianca Crivii |
| author_sort | Alina Simona Șovrea |
| collection | DOAJ |
| description | Despite the massive efforts of modern medicine to stop the evolution of Alzheimer’s disease (AD), it affects an increasing number of people, changing individual lives and imposing itself as a burden on families and the health systems. Considering that the vast majority of conventional drug therapies did not lead to the expected results, this review will discuss the newly developing therapies as an alternative in the effort to stop or slow AD. Focused Ultrasound (FUS) and its derived Transcranial Pulse Stimulation (TPS) are non-invasive therapeutic approaches. Singly or as an applied technique to change the permeability of the blood–brain–barrier (BBB), FUS and TPS have demonstrated the benefits of use in treating AD in animal and human studies. Adipose-derived stem Cells (ADSCs), gene therapy, and many other alternative methods (diet, sleep pattern, physical exercise, nanoparticle delivery) are also new potential treatments since multimodal approaches represent the modern trend in this disorder research therapies. |
| format | Article |
| id | doaj-art-37d956357a3c47dc8582ee330c9e551d |
| institution | Kabale University |
| issn | 2227-9059 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj-art-37d956357a3c47dc8582ee330c9e551d2025-01-24T13:23:57ZengMDPI AGBiomedicines2227-90592025-01-011318410.3390/biomedicines13010084Non-Drug and Non-Invasive Therapeutic Options in Alzheimer’s DiseaseAlina Simona Șovrea0Adina Bianca Boșca1Eleonora Dronca2Anne-Marie Constantin3Andreea Crintea4Rada Suflețel5Roxana Adelina Ștefan6Paul Andrei Ștefan7Mădălin Mihai Onofrei8Christoph Tschall9Carmen-Bianca Crivii10Morpho-Functional Sciences Department, Iuliu Hațieganu University of Medicine and Pharmacy, 400347 Cluj-Napoca, RomaniaMorpho-Functional Sciences Department, Iuliu Hațieganu University of Medicine and Pharmacy, 400347 Cluj-Napoca, RomaniaMolecular Sciences Department, Iuliu Hațieganu University of Medicine and Pharmacy, 400347 Cluj-Napoca, RomaniaMorpho-Functional Sciences Department, Iuliu Hațieganu University of Medicine and Pharmacy, 400347 Cluj-Napoca, RomaniaMolecular Sciences Department, Iuliu Hațieganu University of Medicine and Pharmacy, 400347 Cluj-Napoca, RomaniaMorpho-Functional Sciences Department, Iuliu Hațieganu University of Medicine and Pharmacy, 400347 Cluj-Napoca, RomaniaMorpho-Functional Sciences Department, Iuliu Hațieganu University of Medicine and Pharmacy, 400347 Cluj-Napoca, RomaniaRadiology and Imaging Department, Emergency County Hospital Cluj, 400347 Cluj-Napoca, RomaniaMorpho-Functional Sciences Department, Iuliu Hațieganu University of Medicine and Pharmacy, 400347 Cluj-Napoca, RomaniaMorpho-Functional Sciences Department, Iuliu Hațieganu University of Medicine and Pharmacy, 400347 Cluj-Napoca, RomaniaMorpho-Functional Sciences Department, Iuliu Hațieganu University of Medicine and Pharmacy, 400347 Cluj-Napoca, RomaniaDespite the massive efforts of modern medicine to stop the evolution of Alzheimer’s disease (AD), it affects an increasing number of people, changing individual lives and imposing itself as a burden on families and the health systems. Considering that the vast majority of conventional drug therapies did not lead to the expected results, this review will discuss the newly developing therapies as an alternative in the effort to stop or slow AD. Focused Ultrasound (FUS) and its derived Transcranial Pulse Stimulation (TPS) are non-invasive therapeutic approaches. Singly or as an applied technique to change the permeability of the blood–brain–barrier (BBB), FUS and TPS have demonstrated the benefits of use in treating AD in animal and human studies. Adipose-derived stem Cells (ADSCs), gene therapy, and many other alternative methods (diet, sleep pattern, physical exercise, nanoparticle delivery) are also new potential treatments since multimodal approaches represent the modern trend in this disorder research therapies.https://www.mdpi.com/2227-9059/13/1/84Alzheimer’s diseasenon-drugnon-invasivetherapeutic optionsFUSTPS |
| spellingShingle | Alina Simona Șovrea Adina Bianca Boșca Eleonora Dronca Anne-Marie Constantin Andreea Crintea Rada Suflețel Roxana Adelina Ștefan Paul Andrei Ștefan Mădălin Mihai Onofrei Christoph Tschall Carmen-Bianca Crivii Non-Drug and Non-Invasive Therapeutic Options in Alzheimer’s Disease Biomedicines Alzheimer’s disease non-drug non-invasive therapeutic options FUS TPS |
| title | Non-Drug and Non-Invasive Therapeutic Options in Alzheimer’s Disease |
| title_full | Non-Drug and Non-Invasive Therapeutic Options in Alzheimer’s Disease |
| title_fullStr | Non-Drug and Non-Invasive Therapeutic Options in Alzheimer’s Disease |
| title_full_unstemmed | Non-Drug and Non-Invasive Therapeutic Options in Alzheimer’s Disease |
| title_short | Non-Drug and Non-Invasive Therapeutic Options in Alzheimer’s Disease |
| title_sort | non drug and non invasive therapeutic options in alzheimer s disease |
| topic | Alzheimer’s disease non-drug non-invasive therapeutic options FUS TPS |
| url | https://www.mdpi.com/2227-9059/13/1/84 |
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