CNS Vasculitis Associated with Waldenström Macroglobulinemia
Waldenström macroglobulinemia (WM) is an indolent B cell lymphoproliferative disorder with monoclonal IgM secretion. We present a patient with WM who presented with multifocal acute cortical ischemic strokes and was found to have central nervous system (CNS) vasculitis. Workup was negative for cryog...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Case Reports in Neurological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2016/2510573 |
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| author | Tanawan Riangwiwat Chris Y. Wu Alberto S. Santos-Ocampo Randal J. Liu Aaron M. McMurtray Beau K. Nakamoto |
| author_facet | Tanawan Riangwiwat Chris Y. Wu Alberto S. Santos-Ocampo Randal J. Liu Aaron M. McMurtray Beau K. Nakamoto |
| author_sort | Tanawan Riangwiwat |
| collection | DOAJ |
| description | Waldenström macroglobulinemia (WM) is an indolent B cell lymphoproliferative disorder with monoclonal IgM secretion. We present a patient with WM who presented with multifocal acute cortical ischemic strokes and was found to have central nervous system (CNS) vasculitis. Workup was negative for cryoglobulins and hyperviscosity syndrome. Immunosuppression with intravenous steroids and cyclophosphamide stabilized the patient’s mental status and neurologic deficits. On followup over 7 years, patient gained independence from walking aids and experienced no recurrences of CNS vasculitis. To our knowledge, CNS vasculitis in a WM patient, in the absence of cryoglobulins, has not been reported. Immunosuppression is the preferred treatment. |
| format | Article |
| id | doaj-art-37d8c0ef9fa3493982b084e9862bf454 |
| institution | Kabale University |
| issn | 2090-6668 2090-6676 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Neurological Medicine |
| spelling | doaj-art-37d8c0ef9fa3493982b084e9862bf4542025-02-03T06:08:13ZengWileyCase Reports in Neurological Medicine2090-66682090-66762016-01-01201610.1155/2016/25105732510573CNS Vasculitis Associated with Waldenström MacroglobulinemiaTanawan Riangwiwat0Chris Y. Wu1Alberto S. Santos-Ocampo2Randal J. Liu3Aaron M. McMurtray4Beau K. Nakamoto5Department of Medicine, University of Hawaii, Honolulu, HI, USADepartment of Medicine, University of Hawaii, Honolulu, HI, USADepartment of Rheumatology, Straub Clinics and Hospital, Honolulu, HI, USADepartment of Oncology, Straub Clinics and Hospital, Honolulu, HI, USADepartment of Neurology, Harbor-UCLA Medical Center, Torrance, CA, USADepartment of Medicine, University of Hawaii, Honolulu, HI, USAWaldenström macroglobulinemia (WM) is an indolent B cell lymphoproliferative disorder with monoclonal IgM secretion. We present a patient with WM who presented with multifocal acute cortical ischemic strokes and was found to have central nervous system (CNS) vasculitis. Workup was negative for cryoglobulins and hyperviscosity syndrome. Immunosuppression with intravenous steroids and cyclophosphamide stabilized the patient’s mental status and neurologic deficits. On followup over 7 years, patient gained independence from walking aids and experienced no recurrences of CNS vasculitis. To our knowledge, CNS vasculitis in a WM patient, in the absence of cryoglobulins, has not been reported. Immunosuppression is the preferred treatment.http://dx.doi.org/10.1155/2016/2510573 |
| spellingShingle | Tanawan Riangwiwat Chris Y. Wu Alberto S. Santos-Ocampo Randal J. Liu Aaron M. McMurtray Beau K. Nakamoto CNS Vasculitis Associated with Waldenström Macroglobulinemia Case Reports in Neurological Medicine |
| title | CNS Vasculitis Associated with Waldenström Macroglobulinemia |
| title_full | CNS Vasculitis Associated with Waldenström Macroglobulinemia |
| title_fullStr | CNS Vasculitis Associated with Waldenström Macroglobulinemia |
| title_full_unstemmed | CNS Vasculitis Associated with Waldenström Macroglobulinemia |
| title_short | CNS Vasculitis Associated with Waldenström Macroglobulinemia |
| title_sort | cns vasculitis associated with waldenstrom macroglobulinemia |
| url | http://dx.doi.org/10.1155/2016/2510573 |
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