Daily Feeding of Fructooligosaccharide or Glucomannan Delays Onset of Senescence in SAMP8 Mice
We hypothesized that daily intake of nondigestible saccharides delays senescence onset through the improvement of intestinal microflora. Here, we raised senescence accelerated mice prone 8 (SAMP8) on the AIN93 diet (CONT), with sucrose being substituted for 5% of fructooligosaccharide (FOS) or 5% of...
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| Format: | Article |
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Wiley
2014-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2014/303184 |
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| author | Sadako Nakamura Naoyuki Kondo Yoshitake Yamaguchi Michiru Hashiguchi Kenichi Tanabe Chihiro Ushiroda Miho Kawahashi-Tokuhisa Katsuyuki Yui Mana Miyakoda Tsuneyuki Oku |
| author_facet | Sadako Nakamura Naoyuki Kondo Yoshitake Yamaguchi Michiru Hashiguchi Kenichi Tanabe Chihiro Ushiroda Miho Kawahashi-Tokuhisa Katsuyuki Yui Mana Miyakoda Tsuneyuki Oku |
| author_sort | Sadako Nakamura |
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| description | We hypothesized that daily intake of nondigestible saccharides delays senescence onset through the improvement of intestinal microflora. Here, we raised senescence accelerated mice prone 8 (SAMP8) on the AIN93 diet (CONT), with sucrose being substituted for 5% of fructooligosaccharide (FOS) or 5% of glucomannan (GM), 15 mice per group. Ten SAMR1 were raised as reference of normal aging with control diet. Grading of senescence was conducted using the method developed by Hosokawa, and body weight, dietary intake, and drinking water intake were measured on alternate days. Following 38 weeks of these diets we evaluated learning and memory abilities using a passive avoidance apparatus and investigated effects on the intestinal microflora, measured oxidative stress markers, and inflammatory cytokines. Continuous intake of FOS and GM significantly enhanced learning and memory ability and decelerated senescence development when compared with the CONT group. Bifidobacterium levels were significantly increased in FOS and GM-fed mice. Urinary 8OHdG, 15-isoprostane, serum TNF-α, and IL-6 were also lower in FOS-fed mice, while IL-10 in FOS and GM groups was higher than in CONT group. These findings suggest that daily intake of nondigestible saccharides delays the onset of senescence via improvement of intestinal microflora. |
| format | Article |
| id | doaj-art-37a3debf3e72448c8b28b02b744c89a8 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
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| series | Gastroenterology Research and Practice |
| spelling | doaj-art-37a3debf3e72448c8b28b02b744c89a82025-02-03T01:11:59ZengWileyGastroenterology Research and Practice1687-61211687-630X2014-01-01201410.1155/2014/303184303184Daily Feeding of Fructooligosaccharide or Glucomannan Delays Onset of Senescence in SAMP8 MiceSadako Nakamura0Naoyuki Kondo1Yoshitake Yamaguchi2Michiru Hashiguchi3Kenichi Tanabe4Chihiro Ushiroda5Miho Kawahashi-Tokuhisa6Katsuyuki Yui7Mana Miyakoda8Tsuneyuki Oku9Graduate School of Human Health Science, University of Nagasaki Siebold, 1-1-1 Manabino, Nagayo, Nagasaki 8512195, JapanGraduate School of Human Health Science, University of Nagasaki Siebold, 1-1-1 Manabino, Nagayo, Nagasaki 8512195, JapanGraduate School of Human Health Science, University of Nagasaki Siebold, 1-1-1 Manabino, Nagayo, Nagasaki 8512195, JapanKyoto Koka Women's University, 38 Kadono-cho, Nishikyogoku, Ukyo-ku, Kyoto 6150882, JapanGraduate School of Human Health Science, University of Nagasaki Siebold, 1-1-1 Manabino, Nagayo, Nagasaki 8512195, JapanGraduate School of Human Health Science, University of Nagasaki Siebold, 1-1-1 Manabino, Nagayo, Nagasaki 8512195, JapanGraduate School of Human Health Science, University of Nagasaki Siebold, 1-1-1 Manabino, Nagayo, Nagasaki 8512195, JapanDivision of Immunology, Department of Molecular Microbiology and Immunology, Graduate School of Biomedical Sciences, Nagasaki University, 1-12-4 Sakamoto, Nagasaki 8528523, JapanDivision of Immunology, Department of Molecular Microbiology and Immunology, Graduate School of Biomedical Sciences, Nagasaki University, 1-12-4 Sakamoto, Nagasaki 8528523, JapanGraduate School of Human Health Science, University of Nagasaki Siebold, 1-1-1 Manabino, Nagayo, Nagasaki 8512195, JapanWe hypothesized that daily intake of nondigestible saccharides delays senescence onset through the improvement of intestinal microflora. Here, we raised senescence accelerated mice prone 8 (SAMP8) on the AIN93 diet (CONT), with sucrose being substituted for 5% of fructooligosaccharide (FOS) or 5% of glucomannan (GM), 15 mice per group. Ten SAMR1 were raised as reference of normal aging with control diet. Grading of senescence was conducted using the method developed by Hosokawa, and body weight, dietary intake, and drinking water intake were measured on alternate days. Following 38 weeks of these diets we evaluated learning and memory abilities using a passive avoidance apparatus and investigated effects on the intestinal microflora, measured oxidative stress markers, and inflammatory cytokines. Continuous intake of FOS and GM significantly enhanced learning and memory ability and decelerated senescence development when compared with the CONT group. Bifidobacterium levels were significantly increased in FOS and GM-fed mice. Urinary 8OHdG, 15-isoprostane, serum TNF-α, and IL-6 were also lower in FOS-fed mice, while IL-10 in FOS and GM groups was higher than in CONT group. These findings suggest that daily intake of nondigestible saccharides delays the onset of senescence via improvement of intestinal microflora.http://dx.doi.org/10.1155/2014/303184 |
| spellingShingle | Sadako Nakamura Naoyuki Kondo Yoshitake Yamaguchi Michiru Hashiguchi Kenichi Tanabe Chihiro Ushiroda Miho Kawahashi-Tokuhisa Katsuyuki Yui Mana Miyakoda Tsuneyuki Oku Daily Feeding of Fructooligosaccharide or Glucomannan Delays Onset of Senescence in SAMP8 Mice Gastroenterology Research and Practice |
| title | Daily Feeding of Fructooligosaccharide or Glucomannan Delays Onset of Senescence in SAMP8 Mice |
| title_full | Daily Feeding of Fructooligosaccharide or Glucomannan Delays Onset of Senescence in SAMP8 Mice |
| title_fullStr | Daily Feeding of Fructooligosaccharide or Glucomannan Delays Onset of Senescence in SAMP8 Mice |
| title_full_unstemmed | Daily Feeding of Fructooligosaccharide or Glucomannan Delays Onset of Senescence in SAMP8 Mice |
| title_short | Daily Feeding of Fructooligosaccharide or Glucomannan Delays Onset of Senescence in SAMP8 Mice |
| title_sort | daily feeding of fructooligosaccharide or glucomannan delays onset of senescence in samp8 mice |
| url | http://dx.doi.org/10.1155/2014/303184 |
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