When Ribonucleases Come into Play in Pathogens: A Survey of Gram-Positive Bacteria
It is widely acknowledged that RNA stability plays critical roles in bacterial adaptation and survival in different environments like those encountered when bacteria infect a host. Bacterial ribonucleases acting alone or in concert with regulatory RNAs or RNA binding proteins are the mediators of th...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Microbiology |
| Online Access: | http://dx.doi.org/10.1155/2012/592196 |
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| author | Brian C. Jester Pascale Romby Efthimia Lioliou |
| author_facet | Brian C. Jester Pascale Romby Efthimia Lioliou |
| author_sort | Brian C. Jester |
| collection | DOAJ |
| description | It is widely acknowledged that RNA stability plays critical roles in bacterial adaptation and survival in different environments like those encountered when bacteria infect a host. Bacterial ribonucleases acting alone or in concert with regulatory RNAs or RNA binding proteins are the mediators of the regulatory outcome on RNA stability. We will give a current update of what is known about ribonucleases in the model Gram-positive organism Bacillus subtilis and will describe their established roles in virulence in several Gram-positive pathogenic bacteria that are imposing major health concerns worldwide. Implications on bacterial evolution through stabilization/transfer of genetic material (phage or plasmid DNA) as a result of ribonucleases' functions will be covered. The role of ribonucleases in emergence of antibiotic resistance and new concepts in drug design will additionally be discussed. |
| format | Article |
| id | doaj-art-37990c2f6dcf4d48a03b30d0e6765ad5 |
| institution | Kabale University |
| issn | 1687-918X 1687-9198 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Microbiology |
| spelling | doaj-art-37990c2f6dcf4d48a03b30d0e6765ad52025-02-03T05:44:36ZengWileyInternational Journal of Microbiology1687-918X1687-91982012-01-01201210.1155/2012/592196592196When Ribonucleases Come into Play in Pathogens: A Survey of Gram-Positive BacteriaBrian C. Jester0Pascale Romby1Efthimia Lioliou2Architecture et réactivité de l’ARN, UPR 9002 CNRS, IBMC, Université de Strasbourg, 15 rue René Descartes, 67084 Strasbourg, FranceArchitecture et réactivité de l’ARN, UPR 9002 CNRS, IBMC, Université de Strasbourg, 15 rue René Descartes, 67084 Strasbourg, FranceArchitecture et réactivité de l’ARN, UPR 9002 CNRS, IBMC, Université de Strasbourg, 15 rue René Descartes, 67084 Strasbourg, FranceIt is widely acknowledged that RNA stability plays critical roles in bacterial adaptation and survival in different environments like those encountered when bacteria infect a host. Bacterial ribonucleases acting alone or in concert with regulatory RNAs or RNA binding proteins are the mediators of the regulatory outcome on RNA stability. We will give a current update of what is known about ribonucleases in the model Gram-positive organism Bacillus subtilis and will describe their established roles in virulence in several Gram-positive pathogenic bacteria that are imposing major health concerns worldwide. Implications on bacterial evolution through stabilization/transfer of genetic material (phage or plasmid DNA) as a result of ribonucleases' functions will be covered. The role of ribonucleases in emergence of antibiotic resistance and new concepts in drug design will additionally be discussed.http://dx.doi.org/10.1155/2012/592196 |
| spellingShingle | Brian C. Jester Pascale Romby Efthimia Lioliou When Ribonucleases Come into Play in Pathogens: A Survey of Gram-Positive Bacteria International Journal of Microbiology |
| title | When Ribonucleases Come into Play in Pathogens: A Survey of Gram-Positive Bacteria |
| title_full | When Ribonucleases Come into Play in Pathogens: A Survey of Gram-Positive Bacteria |
| title_fullStr | When Ribonucleases Come into Play in Pathogens: A Survey of Gram-Positive Bacteria |
| title_full_unstemmed | When Ribonucleases Come into Play in Pathogens: A Survey of Gram-Positive Bacteria |
| title_short | When Ribonucleases Come into Play in Pathogens: A Survey of Gram-Positive Bacteria |
| title_sort | when ribonucleases come into play in pathogens a survey of gram positive bacteria |
| url | http://dx.doi.org/10.1155/2012/592196 |
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