A Neural Correlate of Predicted and Actual Reward-Value Information in Monkey Pedunculopontine Tegmental and Dorsal Raphe Nucleus during Saccade Tasks
Dopamine, acetylcholine, and serotonin, the main modulators of the central nervous system, have been proposed to play important roles in the execution of movement, control of several forms of attentional behavior, and reinforcement learning. While the response pattern of midbrain dopaminergic neuron...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2011/579840 |
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| author | Ken-ichi Okada Kae Nakamura Yasushi Kobayashi |
| author_facet | Ken-ichi Okada Kae Nakamura Yasushi Kobayashi |
| author_sort | Ken-ichi Okada |
| collection | DOAJ |
| description | Dopamine, acetylcholine, and serotonin, the main modulators of the central nervous system, have been proposed to play important roles in the execution of movement, control of several forms of attentional behavior, and reinforcement learning. While the response pattern of midbrain dopaminergic neurons and its specific role in reinforcement learning have been revealed, the role of the other neuromodulators remains rather elusive. Here, we review our recent studies using extracellular recording from neurons in the pedunculopontine tegmental nucleus, where many cholinergic neurons exist, and the dorsal raphe nucleus, where many serotonergic neurons exist, while monkeys performed eye movement tasks to obtain different reward values. The firing patterns of these neurons are often tonic throughout the task period, while dopaminergic neurons exhibited a phasic activity pattern to the task event. The different modulation patterns, together with the activity of dopaminergic neurons, reveal dynamic information processing between these different neuromodulator systems. |
| format | Article |
| id | doaj-art-3790fbffb09d44d6928059610e20d0f0 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-3790fbffb09d44d6928059610e20d0f02025-02-03T06:12:38ZengWileyNeural Plasticity2090-59041687-54432011-01-01201110.1155/2011/579840579840A Neural Correlate of Predicted and Actual Reward-Value Information in Monkey Pedunculopontine Tegmental and Dorsal Raphe Nucleus during Saccade TasksKen-ichi Okada0Kae Nakamura1Yasushi Kobayashi2Graduate School of Frontier Biosciences, Osaka University, 1-3 Machikaneyama, Toyonaka 560-8531, JapanDepartment of Physiology, Kansai Medical University, 10-15 Fumizono-cho, Moriguchi City, Osaka 570-8506, JapanGraduate School of Frontier Biosciences, Osaka University, 1-3 Machikaneyama, Toyonaka 560-8531, JapanDopamine, acetylcholine, and serotonin, the main modulators of the central nervous system, have been proposed to play important roles in the execution of movement, control of several forms of attentional behavior, and reinforcement learning. While the response pattern of midbrain dopaminergic neurons and its specific role in reinforcement learning have been revealed, the role of the other neuromodulators remains rather elusive. Here, we review our recent studies using extracellular recording from neurons in the pedunculopontine tegmental nucleus, where many cholinergic neurons exist, and the dorsal raphe nucleus, where many serotonergic neurons exist, while monkeys performed eye movement tasks to obtain different reward values. The firing patterns of these neurons are often tonic throughout the task period, while dopaminergic neurons exhibited a phasic activity pattern to the task event. The different modulation patterns, together with the activity of dopaminergic neurons, reveal dynamic information processing between these different neuromodulator systems.http://dx.doi.org/10.1155/2011/579840 |
| spellingShingle | Ken-ichi Okada Kae Nakamura Yasushi Kobayashi A Neural Correlate of Predicted and Actual Reward-Value Information in Monkey Pedunculopontine Tegmental and Dorsal Raphe Nucleus during Saccade Tasks Neural Plasticity |
| title | A Neural Correlate of Predicted and Actual Reward-Value Information in Monkey Pedunculopontine Tegmental and Dorsal Raphe Nucleus during Saccade Tasks |
| title_full | A Neural Correlate of Predicted and Actual Reward-Value Information in Monkey Pedunculopontine Tegmental and Dorsal Raphe Nucleus during Saccade Tasks |
| title_fullStr | A Neural Correlate of Predicted and Actual Reward-Value Information in Monkey Pedunculopontine Tegmental and Dorsal Raphe Nucleus during Saccade Tasks |
| title_full_unstemmed | A Neural Correlate of Predicted and Actual Reward-Value Information in Monkey Pedunculopontine Tegmental and Dorsal Raphe Nucleus during Saccade Tasks |
| title_short | A Neural Correlate of Predicted and Actual Reward-Value Information in Monkey Pedunculopontine Tegmental and Dorsal Raphe Nucleus during Saccade Tasks |
| title_sort | neural correlate of predicted and actual reward value information in monkey pedunculopontine tegmental and dorsal raphe nucleus during saccade tasks |
| url | http://dx.doi.org/10.1155/2011/579840 |
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