Acitretin Treatment for Lipoid Proteinosis
Lipoid proteinosis (LP) is a rare, autosomal-recessive disease characterized by the hoarseness and widespread cutaneous scarring, more prominent on sun-exposed areas. Yellow-white plaques can be seen on oral mucosa and on the skin among depressed scars. Histological evaluation of the affected sites...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Case Reports in Dermatological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2012/324506 |
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| author | Özgür Gündüz Neriman Şahiner Pınar Atasoy Çağrı Şenyücel |
| author_facet | Özgür Gündüz Neriman Şahiner Pınar Atasoy Çağrı Şenyücel |
| author_sort | Özgür Gündüz |
| collection | DOAJ |
| description | Lipoid proteinosis (LP) is a rare, autosomal-recessive disease characterized by the hoarseness and widespread cutaneous scarring, more prominent on sun-exposed areas. Yellow-white plaques can be seen on oral mucosa and on the skin among depressed scars. Histological evaluation of the affected sites shows accumulation of hyaline-like material in dermis and disruption of basement membrane. Although LP is compatible with normal life expectancy, involvement of upper respiratory tract may endanger patient's life, especially in the case of a respiratory tract infection. Involvement of central nervous system has also been reported, but its clinical importance is obscure. Due to the rarity of LP, a definite therapeutical approach is not established. In this paper we describe a 21-year-old LP patient who was treated with acitretin for six months. Although the outcome with cutaneous lesions was not satisfactory, her hoarseness was significantly improved. |
| format | Article |
| id | doaj-art-378a639b49cc457297128c5f0cfe690b |
| institution | Kabale University |
| issn | 2090-6463 2090-6471 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Dermatological Medicine |
| spelling | doaj-art-378a639b49cc457297128c5f0cfe690b2025-02-03T01:28:00ZengWileyCase Reports in Dermatological Medicine2090-64632090-64712012-01-01201210.1155/2012/324506324506Acitretin Treatment for Lipoid ProteinosisÖzgür Gündüz0Neriman Şahiner1Pınar Atasoy2Çağrı Şenyücel3Department of Dermatology and Venerology, Suleyman Demirel Teaching Hospital, University of Kırıkkale, Fabrikalar Mahallesi, Saglık Sokak, Kırıkkale 71100, TurkeyDepartment of Dermatology and Venerology, Suleyman Demirel Teaching Hospital, University of Kırıkkale, Fabrikalar Mahallesi, Saglık Sokak, Kırıkkale 71100, TurkeyDepartment of Pathology, School of Medicine, Kırıkkale University, Kirikkale 71100, TurkeyDepartment of Radiodiagnostics, School of Medicine, Kırıkkale University, Kirikkale 71100, TurkeyLipoid proteinosis (LP) is a rare, autosomal-recessive disease characterized by the hoarseness and widespread cutaneous scarring, more prominent on sun-exposed areas. Yellow-white plaques can be seen on oral mucosa and on the skin among depressed scars. Histological evaluation of the affected sites shows accumulation of hyaline-like material in dermis and disruption of basement membrane. Although LP is compatible with normal life expectancy, involvement of upper respiratory tract may endanger patient's life, especially in the case of a respiratory tract infection. Involvement of central nervous system has also been reported, but its clinical importance is obscure. Due to the rarity of LP, a definite therapeutical approach is not established. In this paper we describe a 21-year-old LP patient who was treated with acitretin for six months. Although the outcome with cutaneous lesions was not satisfactory, her hoarseness was significantly improved.http://dx.doi.org/10.1155/2012/324506 |
| spellingShingle | Özgür Gündüz Neriman Şahiner Pınar Atasoy Çağrı Şenyücel Acitretin Treatment for Lipoid Proteinosis Case Reports in Dermatological Medicine |
| title | Acitretin Treatment for Lipoid Proteinosis |
| title_full | Acitretin Treatment for Lipoid Proteinosis |
| title_fullStr | Acitretin Treatment for Lipoid Proteinosis |
| title_full_unstemmed | Acitretin Treatment for Lipoid Proteinosis |
| title_short | Acitretin Treatment for Lipoid Proteinosis |
| title_sort | acitretin treatment for lipoid proteinosis |
| url | http://dx.doi.org/10.1155/2012/324506 |
| work_keys_str_mv | AT ozgurgunduz acitretintreatmentforlipoidproteinosis AT nerimansahiner acitretintreatmentforlipoidproteinosis AT pınaratasoy acitretintreatmentforlipoidproteinosis AT cagrısenyucel acitretintreatmentforlipoidproteinosis |