Protein-bound uremic toxins as therapeutic targets for cardiovascular, kidney, and metabolic disorders
Cardiovascular-kidney-metabolic (CKM) syndrome is a systemic clinical condition characterized by pathological and physiological interactions among metabolic abnormalities, chronic kidney disease, and cardiovascular diseases, leading to multi-organ dysfunction and a higher incidence of cardiovascular...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2025.1500336/full |
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| author | Shihan Zhang Shasha Tang Yalei Liu Binghua Xue Qinyuan Xie Lingyun Zhao Huijuan Yuan |
| author_facet | Shihan Zhang Shasha Tang Yalei Liu Binghua Xue Qinyuan Xie Lingyun Zhao Huijuan Yuan |
| author_sort | Shihan Zhang |
| collection | DOAJ |
| description | Cardiovascular-kidney-metabolic (CKM) syndrome is a systemic clinical condition characterized by pathological and physiological interactions among metabolic abnormalities, chronic kidney disease, and cardiovascular diseases, leading to multi-organ dysfunction and a higher incidence of cardiovascular endpoints. Traditional approaches to managing CKM syndrome risk are inadequate in these patients, necessitating strategies targeting specific CKM syndrome risk factors. Increasing evidence suggests that addressing uremic toxins and/or pathways induced by uremic toxins may reduce CKM syndrome risk and treat the disease. This review explores the interactions among heart, kidney, and metabolic pathways in the context of uremic toxins and underscores the significant role of uremic toxins as potential therapeutic targets in the pathophysiology of these diseases. Strategies aimed at regulating these uremic toxins offer potential avenues for reversing and managing CKM syndrome, providing new insights for its clinical diagnosis and treatment. |
| format | Article |
| id | doaj-art-37784a13cfec4665b8960603800de9c0 |
| institution | Kabale University |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj-art-37784a13cfec4665b8960603800de9c02025-01-27T06:40:39ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-01-011610.3389/fendo.2025.15003361500336Protein-bound uremic toxins as therapeutic targets for cardiovascular, kidney, and metabolic disordersShihan ZhangShasha TangYalei LiuBinghua XueQinyuan XieLingyun ZhaoHuijuan YuanCardiovascular-kidney-metabolic (CKM) syndrome is a systemic clinical condition characterized by pathological and physiological interactions among metabolic abnormalities, chronic kidney disease, and cardiovascular diseases, leading to multi-organ dysfunction and a higher incidence of cardiovascular endpoints. Traditional approaches to managing CKM syndrome risk are inadequate in these patients, necessitating strategies targeting specific CKM syndrome risk factors. Increasing evidence suggests that addressing uremic toxins and/or pathways induced by uremic toxins may reduce CKM syndrome risk and treat the disease. This review explores the interactions among heart, kidney, and metabolic pathways in the context of uremic toxins and underscores the significant role of uremic toxins as potential therapeutic targets in the pathophysiology of these diseases. Strategies aimed at regulating these uremic toxins offer potential avenues for reversing and managing CKM syndrome, providing new insights for its clinical diagnosis and treatment.https://www.frontiersin.org/articles/10.3389/fendo.2025.1500336/fullprotein-bound uremic toxinsgut microbiotacardiovascular-kidney-metabolic syndromemetabolic diseasesmanagement |
| spellingShingle | Shihan Zhang Shasha Tang Yalei Liu Binghua Xue Qinyuan Xie Lingyun Zhao Huijuan Yuan Protein-bound uremic toxins as therapeutic targets for cardiovascular, kidney, and metabolic disorders Frontiers in Endocrinology protein-bound uremic toxins gut microbiota cardiovascular-kidney-metabolic syndrome metabolic diseases management |
| title | Protein-bound uremic toxins as therapeutic targets for cardiovascular, kidney, and metabolic disorders |
| title_full | Protein-bound uremic toxins as therapeutic targets for cardiovascular, kidney, and metabolic disorders |
| title_fullStr | Protein-bound uremic toxins as therapeutic targets for cardiovascular, kidney, and metabolic disorders |
| title_full_unstemmed | Protein-bound uremic toxins as therapeutic targets for cardiovascular, kidney, and metabolic disorders |
| title_short | Protein-bound uremic toxins as therapeutic targets for cardiovascular, kidney, and metabolic disorders |
| title_sort | protein bound uremic toxins as therapeutic targets for cardiovascular kidney and metabolic disorders |
| topic | protein-bound uremic toxins gut microbiota cardiovascular-kidney-metabolic syndrome metabolic diseases management |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2025.1500336/full |
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