PFOA, PFOS and PFHxS toxicokinetic considerations for the development of an in vivo approach for assessing PFAS relative bioavailability in soil
A Sprague-Dawley rat model was utilized to elucidate perfluorooctanoic acid (PFOA), perfluorooctanesulfonic acid (PFOS) and perfluorohexanesulfonic acid (PFHxS) toxicokinetics with a goal of developing an in vivo approach for quantifying PFAS relative bioavailability in impacted soil. Following sing...
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Elsevier
2025-01-01
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| Series: | Environment International |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0160412024008195 |
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| author | Albert L. Juhasz Farzana Kastury Ruby Jones Mahima Seeborun Tanya Caceres Carina Herde Michelle Cavallaro Sarah Dilmetz Joshua Hutchings Yevgeniya Grebneva Chris Desire Peter Hoffmann |
| author_facet | Albert L. Juhasz Farzana Kastury Ruby Jones Mahima Seeborun Tanya Caceres Carina Herde Michelle Cavallaro Sarah Dilmetz Joshua Hutchings Yevgeniya Grebneva Chris Desire Peter Hoffmann |
| author_sort | Albert L. Juhasz |
| collection | DOAJ |
| description | A Sprague-Dawley rat model was utilized to elucidate perfluorooctanoic acid (PFOA), perfluorooctanesulfonic acid (PFOS) and perfluorohexanesulfonic acid (PFHxS) toxicokinetics with a goal of developing an in vivo approach for quantifying PFAS relative bioavailability in impacted soil. Following single dose administration (gavage) of ∼ 0.2–2000 µg kg−1 BW of PFOA, PFOS or PFHxS, differences in PFAS blood, organ and excreta concentrations were observed over 120 h although linear dose responses were determined for area under the blood plasma time curves (AUC; PFOA, PFHxS), liver accumulation (LA: PFOS) and urinary excretion (UE; PFOA, PFHxS). Oral and intravenous dose (∼20 µg kg−1 body weight) comparisons highlighted the high absolute bioavailability of PFOA (AUC: 100.3 ± 23.4 %; UE: 94.7 ± 26.6 %), PFOS (LA: 102.9 ± 15.6 %) and PFHxS (AUC: 88.3 ± 15.1 %; UE: 90.9 ± 7.3 %). Two spiked (14C-PFOA: 4360 ± 218 µg kg−1) and two PFAS impacted soils (PFOS: 1880–2250 µg kg−1; PFHxS: 61.2–65.5 µg kg−1) were utilized to measure PFAS relative bioavailability in soil matrices. In all soils, PFAS relative bioavailability was > 86 % (PFOA: 87.0–90.9 %; PFOS: 86.1–90.4 %; PFHxS: 86.5–97.0 %) although the method could quantify bioavailability reductions (25.6–88.9 %) when hydrophobic and electrostatic interactions were enhanced through the addition of carbon-based amendments (5–10 % w/w). |
| format | Article |
| id | doaj-art-3772ce5cecf343bda8ee9b8c31cb5a42 |
| institution | Kabale University |
| issn | 0160-4120 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Environment International |
| spelling | doaj-art-3772ce5cecf343bda8ee9b8c31cb5a422025-01-24T04:44:09ZengElsevierEnvironment International0160-41202025-01-01195109232PFOA, PFOS and PFHxS toxicokinetic considerations for the development of an in vivo approach for assessing PFAS relative bioavailability in soilAlbert L. Juhasz0Farzana Kastury1Ruby Jones2Mahima Seeborun3Tanya Caceres4Carina Herde5Michelle Cavallaro6Sarah Dilmetz7Joshua Hutchings8Yevgeniya Grebneva9Chris Desire10Peter Hoffmann11Future Industries Institute, UniSA STEM, University of South Australia, Mawson Lakes Campus, 5095, Australia; Corresponding author at: Future Industries Institute, UniSA STEM, University of South Australia, Building X, Mawson Lakes Campus, Adelaide, SA, 5095, Australia.Future Industries Institute, UniSA STEM, University of South Australia, Mawson Lakes Campus, 5095, AustraliaFuture Industries Institute, UniSA STEM, University of South Australia, Mawson Lakes Campus, 5095, AustraliaFuture Industries Institute, UniSA STEM, University of South Australia, Mawson Lakes Campus, 5095, AustraliaFuture Industries Institute, UniSA STEM, University of South Australia, Mawson Lakes Campus, 5095, AustraliaSouth Australian Health and Medical Research Institute, Preclinical, Imaging and Research Laboratories, 101 Blacks Road, Gilles Plains, Adelaide 5086, AustraliaSouth Australian Health and Medical Research Institute, Preclinical, Imaging and Research Laboratories, 101 Blacks Road, Gilles Plains, Adelaide 5086, AustraliaUniSA Clinical and Health Sciences, University of South Australia, City East Campus, 5000, AustraliaUniSA Clinical and Health Sciences, University of South Australia, City East Campus, 5000, AustraliaUniSA Clinical and Health Sciences, University of South Australia, City East Campus, 5000, AustraliaFuture Industries Institute, UniSA STEM, University of South Australia, Mawson Lakes Campus, 5095, AustraliaUniSA Clinical and Health Sciences, University of South Australia, City East Campus, 5000, AustraliaA Sprague-Dawley rat model was utilized to elucidate perfluorooctanoic acid (PFOA), perfluorooctanesulfonic acid (PFOS) and perfluorohexanesulfonic acid (PFHxS) toxicokinetics with a goal of developing an in vivo approach for quantifying PFAS relative bioavailability in impacted soil. Following single dose administration (gavage) of ∼ 0.2–2000 µg kg−1 BW of PFOA, PFOS or PFHxS, differences in PFAS blood, organ and excreta concentrations were observed over 120 h although linear dose responses were determined for area under the blood plasma time curves (AUC; PFOA, PFHxS), liver accumulation (LA: PFOS) and urinary excretion (UE; PFOA, PFHxS). Oral and intravenous dose (∼20 µg kg−1 body weight) comparisons highlighted the high absolute bioavailability of PFOA (AUC: 100.3 ± 23.4 %; UE: 94.7 ± 26.6 %), PFOS (LA: 102.9 ± 15.6 %) and PFHxS (AUC: 88.3 ± 15.1 %; UE: 90.9 ± 7.3 %). Two spiked (14C-PFOA: 4360 ± 218 µg kg−1) and two PFAS impacted soils (PFOS: 1880–2250 µg kg−1; PFHxS: 61.2–65.5 µg kg−1) were utilized to measure PFAS relative bioavailability in soil matrices. In all soils, PFAS relative bioavailability was > 86 % (PFOA: 87.0–90.9 %; PFOS: 86.1–90.4 %; PFHxS: 86.5–97.0 %) although the method could quantify bioavailability reductions (25.6–88.9 %) when hydrophobic and electrostatic interactions were enhanced through the addition of carbon-based amendments (5–10 % w/w).http://www.sciencedirect.com/science/article/pii/S0160412024008195PFOAPFOSPFHxSBioavailabilityExposureToxicokinetics |
| spellingShingle | Albert L. Juhasz Farzana Kastury Ruby Jones Mahima Seeborun Tanya Caceres Carina Herde Michelle Cavallaro Sarah Dilmetz Joshua Hutchings Yevgeniya Grebneva Chris Desire Peter Hoffmann PFOA, PFOS and PFHxS toxicokinetic considerations for the development of an in vivo approach for assessing PFAS relative bioavailability in soil Environment International PFOA PFOS PFHxS Bioavailability Exposure Toxicokinetics |
| title | PFOA, PFOS and PFHxS toxicokinetic considerations for the development of an in vivo approach for assessing PFAS relative bioavailability in soil |
| title_full | PFOA, PFOS and PFHxS toxicokinetic considerations for the development of an in vivo approach for assessing PFAS relative bioavailability in soil |
| title_fullStr | PFOA, PFOS and PFHxS toxicokinetic considerations for the development of an in vivo approach for assessing PFAS relative bioavailability in soil |
| title_full_unstemmed | PFOA, PFOS and PFHxS toxicokinetic considerations for the development of an in vivo approach for assessing PFAS relative bioavailability in soil |
| title_short | PFOA, PFOS and PFHxS toxicokinetic considerations for the development of an in vivo approach for assessing PFAS relative bioavailability in soil |
| title_sort | pfoa pfos and pfhxs toxicokinetic considerations for the development of an in vivo approach for assessing pfas relative bioavailability in soil |
| topic | PFOA PFOS PFHxS Bioavailability Exposure Toxicokinetics |
| url | http://www.sciencedirect.com/science/article/pii/S0160412024008195 |
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