Bioinspired hierarchical porous tough adhesive to promote sealing of high-pressure bleeding
Timely and stable sealing of uncontrolled high-pressure hemorrhage in emergency situations outside surgical units remains a major clinical challenge, contributing to the high mortality rate associated with trauma. The currently widely used hemostatic bioadhesives are ineffective for hemorrhage from...
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KeAi Communications Co., Ltd.
2025-03-01
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| Series: | Bioactive Materials |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X24004870 |
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| author | Yinghao Li Dongling Xiao Weixi Yan Meilin Jiang Ju Tan Zhongliang Qin Jingting Zhou Yue Sun Mingcan Yang Guanyuan Yang Yawei Gu Yong Liu Chuhong Zhu |
| author_facet | Yinghao Li Dongling Xiao Weixi Yan Meilin Jiang Ju Tan Zhongliang Qin Jingting Zhou Yue Sun Mingcan Yang Guanyuan Yang Yawei Gu Yong Liu Chuhong Zhu |
| author_sort | Yinghao Li |
| collection | DOAJ |
| description | Timely and stable sealing of uncontrolled high-pressure hemorrhage in emergency situations outside surgical units remains a major clinical challenge, contributing to the high mortality rate associated with trauma. The currently widely used hemostatic bioadhesives are ineffective for hemorrhage from major arteries and the heart due to the absence of biologically compatible flexible structures capable of simultaneously ensuring conformal tough adhesion and biomechanical support. Here, inspired by the principle of chromatin assembly, we present a tissue-conformable tough matrix for robust sealing of severe bleeding. This hierarchical matrix is fabricated through a phase separation process, which involves the in-situ formation of nanoporous aggregates within a microporous double-network (DN) matrix. The dispersed aggregates disrupt the rigid physical crosslinking of the original DN matrix and function as a dissipative component, enabling the aggregate-based DN (aggDN) matrix to efficiently dissipate energy during stress and achieve improved conformal attachment to soft tissues. Subsequently, pre-activated bridging polymers facilitate rapid interfacial bonding between the matrix and tissue surfaces. They synergistically withstand considerable hydraulic pressure of approximately 700 mmHg and demonstrate exceptional tissue adhesion and sealing in rat cardiac and canine aortic hemorrhages, outperforming the commercially available bioadhesives. Our findings present a promising biomimetic strategy for engineering biomechanically compatible and tough adhesive hydrogels, facilitating prompt and effective treatment of hemorrhagic wounds. |
| format | Article |
| id | doaj-art-375f285316784dedae316f956a2d8288 |
| institution | Kabale University |
| issn | 2452-199X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Bioactive Materials |
| spelling | doaj-art-375f285316784dedae316f956a2d82882025-01-26T05:04:19ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2025-03-014588101Bioinspired hierarchical porous tough adhesive to promote sealing of high-pressure bleedingYinghao Li0Dongling Xiao1Weixi Yan2Meilin Jiang3Ju Tan4Zhongliang Qin5Jingting Zhou6Yue Sun7Mingcan Yang8Guanyuan Yang9Yawei Gu10Yong Liu11Chuhong Zhu12Department of Anatomy, Engineering Research Center for Organ Intelligent Biological Manufacturing of Chongqing, Key Lab for Biomechanics and Tissue Engineering of Chongqing, Third Military Medical University, Chongqing, 400038, China; Engineering Research Center of Tissue and Organ Regeneration and Manufacturing, Ministry of Education, Chongqing, 400038, China; State Key Laboratory of Trauma and Chemical Poisoning, Chongqing, 400038, ChinaDepartment of Anatomy, Engineering Research Center for Organ Intelligent Biological Manufacturing of Chongqing, Key Lab for Biomechanics and Tissue Engineering of Chongqing, Third Military Medical University, Chongqing, 400038, China; Engineering Research Center of Tissue and Organ Regeneration and Manufacturing, Ministry of Education, Chongqing, 400038, China; State Key Laboratory of Trauma and Chemical Poisoning, Chongqing, 400038, ChinaDepartment of Anatomy, Engineering Research Center for Organ Intelligent Biological Manufacturing of Chongqing, Key Lab for Biomechanics and Tissue Engineering of Chongqing, Third Military Medical University, Chongqing, 400038, China; Engineering Research Center of Tissue and Organ Regeneration and Manufacturing, Ministry of Education, Chongqing, 400038, China; State Key Laboratory of Trauma and Chemical Poisoning, Chongqing, 400038, ChinaDepartment of Anatomy, Engineering Research Center for Organ Intelligent Biological Manufacturing of Chongqing, Key Lab for Biomechanics and Tissue Engineering of Chongqing, Third Military Medical University, Chongqing, 400038, China; Engineering Research Center of Tissue and Organ Regeneration and Manufacturing, Ministry of Education, Chongqing, 400038, China; State Key Laboratory of Trauma and Chemical Poisoning, Chongqing, 400038, ChinaDepartment of Anatomy, Engineering Research Center for Organ Intelligent Biological Manufacturing of Chongqing, Key Lab for Biomechanics and Tissue Engineering of Chongqing, Third Military Medical University, Chongqing, 400038, China; Engineering Research Center of Tissue and Organ Regeneration and Manufacturing, Ministry of Education, Chongqing, 400038, China; State Key Laboratory of Trauma and Chemical Poisoning, Chongqing, 400038, ChinaDepartment of Anatomy, Engineering Research Center for Organ Intelligent Biological Manufacturing of Chongqing, Key Lab for Biomechanics and Tissue Engineering of Chongqing, Third Military Medical University, Chongqing, 400038, China; Engineering Research Center of Tissue and Organ Regeneration and Manufacturing, Ministry of Education, Chongqing, 400038, China; Zhong Zhi Yi Gu Research Institute, Chongqing Jiukang Medical Research Institute Co., Ltd., ChinaDepartment of Anatomy, Engineering Research Center for Organ Intelligent Biological Manufacturing of Chongqing, Key Lab for Biomechanics and Tissue Engineering of Chongqing, Third Military Medical University, Chongqing, 400038, China; Engineering Research Center of Tissue and Organ Regeneration and Manufacturing, Ministry of Education, Chongqing, 400038, China; State Key Laboratory of Trauma and Chemical Poisoning, Chongqing, 400038, ChinaDepartment of Anatomy, Engineering Research Center for Organ Intelligent Biological Manufacturing of Chongqing, Key Lab for Biomechanics and Tissue Engineering of Chongqing, Third Military Medical University, Chongqing, 400038, China; Engineering Research Center of Tissue and Organ Regeneration and Manufacturing, Ministry of Education, Chongqing, 400038, China; State Key Laboratory of Trauma and Chemical Poisoning, Chongqing, 400038, ChinaDepartment of Anatomy, Engineering Research Center for Organ Intelligent Biological Manufacturing of Chongqing, Key Lab for Biomechanics and Tissue Engineering of Chongqing, Third Military Medical University, Chongqing, 400038, China; Engineering Research Center of Tissue and Organ Regeneration and Manufacturing, Ministry of Education, Chongqing, 400038, China; State Key Laboratory of Trauma and Chemical Poisoning, Chongqing, 400038, ChinaDepartment of Anatomy, Engineering Research Center for Organ Intelligent Biological Manufacturing of Chongqing, Key Lab for Biomechanics and Tissue Engineering of Chongqing, Third Military Medical University, Chongqing, 400038, China; Engineering Research Center of Tissue and Organ Regeneration and Manufacturing, Ministry of Education, Chongqing, 400038, China; State Key Laboratory of Trauma and Chemical Poisoning, Chongqing, 400038, ChinaDepartment of Anatomy, Engineering Research Center for Organ Intelligent Biological Manufacturing of Chongqing, Key Lab for Biomechanics and Tissue Engineering of Chongqing, Third Military Medical University, Chongqing, 400038, China; Engineering Research Center of Tissue and Organ Regeneration and Manufacturing, Ministry of Education, Chongqing, 400038, China; State Key Laboratory of Trauma and Chemical Poisoning, Chongqing, 400038, ChinaDepartment of Anatomy, Engineering Research Center for Organ Intelligent Biological Manufacturing of Chongqing, Key Lab for Biomechanics and Tissue Engineering of Chongqing, Third Military Medical University, Chongqing, 400038, China; Engineering Research Center of Tissue and Organ Regeneration and Manufacturing, Ministry of Education, Chongqing, 400038, China; Zhong Zhi Yi Gu Research Institute, Chongqing Jiukang Medical Research Institute Co., Ltd., ChinaDepartment of Anatomy, Engineering Research Center for Organ Intelligent Biological Manufacturing of Chongqing, Key Lab for Biomechanics and Tissue Engineering of Chongqing, Third Military Medical University, Chongqing, 400038, China; Engineering Research Center of Tissue and Organ Regeneration and Manufacturing, Ministry of Education, Chongqing, 400038, China; State Key Laboratory of Trauma and Chemical Poisoning, Chongqing, 400038, China; Corresponding author. Department of Anatomy, Engineering Research Center for Organ Intelligent Biological Manufacturing of Chongqing, Key Lab for Biomechanics and Tissue Engineering of Chongqing, Third Military Medical University, Chongqing, 400038, China.Timely and stable sealing of uncontrolled high-pressure hemorrhage in emergency situations outside surgical units remains a major clinical challenge, contributing to the high mortality rate associated with trauma. The currently widely used hemostatic bioadhesives are ineffective for hemorrhage from major arteries and the heart due to the absence of biologically compatible flexible structures capable of simultaneously ensuring conformal tough adhesion and biomechanical support. Here, inspired by the principle of chromatin assembly, we present a tissue-conformable tough matrix for robust sealing of severe bleeding. This hierarchical matrix is fabricated through a phase separation process, which involves the in-situ formation of nanoporous aggregates within a microporous double-network (DN) matrix. The dispersed aggregates disrupt the rigid physical crosslinking of the original DN matrix and function as a dissipative component, enabling the aggregate-based DN (aggDN) matrix to efficiently dissipate energy during stress and achieve improved conformal attachment to soft tissues. Subsequently, pre-activated bridging polymers facilitate rapid interfacial bonding between the matrix and tissue surfaces. They synergistically withstand considerable hydraulic pressure of approximately 700 mmHg and demonstrate exceptional tissue adhesion and sealing in rat cardiac and canine aortic hemorrhages, outperforming the commercially available bioadhesives. Our findings present a promising biomimetic strategy for engineering biomechanically compatible and tough adhesive hydrogels, facilitating prompt and effective treatment of hemorrhagic wounds.http://www.sciencedirect.com/science/article/pii/S2452199X24004870Uncontrolled hemorrhageBio-inspired phase separationHierarchical porosityAggregate-based matrixTissue-conformable tough adhesion |
| spellingShingle | Yinghao Li Dongling Xiao Weixi Yan Meilin Jiang Ju Tan Zhongliang Qin Jingting Zhou Yue Sun Mingcan Yang Guanyuan Yang Yawei Gu Yong Liu Chuhong Zhu Bioinspired hierarchical porous tough adhesive to promote sealing of high-pressure bleeding Bioactive Materials Uncontrolled hemorrhage Bio-inspired phase separation Hierarchical porosity Aggregate-based matrix Tissue-conformable tough adhesion |
| title | Bioinspired hierarchical porous tough adhesive to promote sealing of high-pressure bleeding |
| title_full | Bioinspired hierarchical porous tough adhesive to promote sealing of high-pressure bleeding |
| title_fullStr | Bioinspired hierarchical porous tough adhesive to promote sealing of high-pressure bleeding |
| title_full_unstemmed | Bioinspired hierarchical porous tough adhesive to promote sealing of high-pressure bleeding |
| title_short | Bioinspired hierarchical porous tough adhesive to promote sealing of high-pressure bleeding |
| title_sort | bioinspired hierarchical porous tough adhesive to promote sealing of high pressure bleeding |
| topic | Uncontrolled hemorrhage Bio-inspired phase separation Hierarchical porosity Aggregate-based matrix Tissue-conformable tough adhesion |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X24004870 |
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