The Role of Pseudocereals in Celiac Disease: Reducing Nutritional Deficiencies to Improve Well-Being and Health

Celiac disease or gluten-dependent enteropathy is a chronic autoimmune pathology triggered by dietary gluten in genetic predisposed individuals, mediated by transglutaminase 2 IgA autoantibodies and associated with a deteriorating immune and inflammatory response. This leads to intestinal villous at...

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Main Authors: Carolina Caeiro, Caroline Pragosa, Marisa Carreira Cruz, Cidália Daniela Pereira, Sónia Gonçalves Pereira
Format: Article
Language:English
Published: Wiley 2022-01-01
Series:Journal of Nutrition and Metabolism
Online Access:http://dx.doi.org/10.1155/2022/8502169
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author Carolina Caeiro
Caroline Pragosa
Marisa Carreira Cruz
Cidália Daniela Pereira
Sónia Gonçalves Pereira
author_facet Carolina Caeiro
Caroline Pragosa
Marisa Carreira Cruz
Cidália Daniela Pereira
Sónia Gonçalves Pereira
author_sort Carolina Caeiro
collection DOAJ
description Celiac disease or gluten-dependent enteropathy is a chronic autoimmune pathology triggered by dietary gluten in genetic predisposed individuals, mediated by transglutaminase 2 IgA autoantibodies and associated with a deteriorating immune and inflammatory response. This leads to intestinal villous atrophy, impairing the intestinal mucosa structure and function of secretion, digestion, and absorption. The result is macro- and micronutrient deficiency, including fat soluble vitamins and minerals, and a consequent nutritional status depletion. A lifelong gluten-free diet is the only available treatment for celiac patients in order to assure normal intestinal mucosa and remission of gastrointestinal symptoms. However, a gluten-free diet can itself cause other nutritional deficiencies due to its restrictive nature regarding gluten-containing cereals. A group of gluten-free cereals, known as pseudocereals, is increasingly recognized as valuable options for gluten-free diets due to their high nutritional value. Amaranth, quinoa, millet, and buckwheat are examples of gluten-free nutrient-dense grains that can be used as alternatives to the conventional gluten-containing grains and improve the variety and nutritional quality of the celiac diet. Current work reviews the nutritional pitfalls of a gluten-free diet and analyses how pseudocereals can contribute to revert those deficiencies and optimize the nutritional value of this mandatory diet for the celiac population.
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spelling doaj-art-3747e64e8dac4ca3833be30cf507b50a2025-02-03T01:02:14ZengWileyJournal of Nutrition and Metabolism2090-07322022-01-01202210.1155/2022/8502169The Role of Pseudocereals in Celiac Disease: Reducing Nutritional Deficiencies to Improve Well-Being and HealthCarolina Caeiro0Caroline Pragosa1Marisa Carreira Cruz2Cidália Daniela Pereira3Sónia Gonçalves Pereira4School of Health SciencesSchool of Health SciencesSchool of Health SciencesSchool of Health SciencesCenter for Innovative Care and Health TechnologyCeliac disease or gluten-dependent enteropathy is a chronic autoimmune pathology triggered by dietary gluten in genetic predisposed individuals, mediated by transglutaminase 2 IgA autoantibodies and associated with a deteriorating immune and inflammatory response. This leads to intestinal villous atrophy, impairing the intestinal mucosa structure and function of secretion, digestion, and absorption. The result is macro- and micronutrient deficiency, including fat soluble vitamins and minerals, and a consequent nutritional status depletion. A lifelong gluten-free diet is the only available treatment for celiac patients in order to assure normal intestinal mucosa and remission of gastrointestinal symptoms. However, a gluten-free diet can itself cause other nutritional deficiencies due to its restrictive nature regarding gluten-containing cereals. A group of gluten-free cereals, known as pseudocereals, is increasingly recognized as valuable options for gluten-free diets due to their high nutritional value. Amaranth, quinoa, millet, and buckwheat are examples of gluten-free nutrient-dense grains that can be used as alternatives to the conventional gluten-containing grains and improve the variety and nutritional quality of the celiac diet. Current work reviews the nutritional pitfalls of a gluten-free diet and analyses how pseudocereals can contribute to revert those deficiencies and optimize the nutritional value of this mandatory diet for the celiac population.http://dx.doi.org/10.1155/2022/8502169
spellingShingle Carolina Caeiro
Caroline Pragosa
Marisa Carreira Cruz
Cidália Daniela Pereira
Sónia Gonçalves Pereira
The Role of Pseudocereals in Celiac Disease: Reducing Nutritional Deficiencies to Improve Well-Being and Health
Journal of Nutrition and Metabolism
title The Role of Pseudocereals in Celiac Disease: Reducing Nutritional Deficiencies to Improve Well-Being and Health
title_full The Role of Pseudocereals in Celiac Disease: Reducing Nutritional Deficiencies to Improve Well-Being and Health
title_fullStr The Role of Pseudocereals in Celiac Disease: Reducing Nutritional Deficiencies to Improve Well-Being and Health
title_full_unstemmed The Role of Pseudocereals in Celiac Disease: Reducing Nutritional Deficiencies to Improve Well-Being and Health
title_short The Role of Pseudocereals in Celiac Disease: Reducing Nutritional Deficiencies to Improve Well-Being and Health
title_sort role of pseudocereals in celiac disease reducing nutritional deficiencies to improve well being and health
url http://dx.doi.org/10.1155/2022/8502169
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