Simulation of single-species bacterial-biofilm growth using the Glazier-Graner-Hogeweg model and the CompuCell3D modeling environment
The CompuCell3D modeling environment provides a convenientplatform for biofilm simulations using the Glazier-Graner-Hogeweg (GGH)model, a cell-oriented framework designed to simulate growth and patternformation due to biological cells' behaviors. We show how to develop sucha simulation, based o...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
AIMS Press
2008-02-01
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| Series: | Mathematical Biosciences and Engineering |
| Subjects: | |
| Online Access: | https://www.aimspress.com/article/doi/10.3934/mbe.2008.5.355 |
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| Summary: | The CompuCell3D modeling environment provides a convenientplatform for biofilm simulations using the Glazier-Graner-Hogeweg (GGH)model, a cell-oriented framework designed to simulate growth and patternformation due to biological cells' behaviors. We show how to develop sucha simulation, based on the hybrid (continuum-discrete) model of Picioreanu,van Loosdrecht, and Heijnen (PLH), simulate the growth of a single-speciesbacterial biofilm, and study the roles of cell-cell and cell-field interactions indetermining biofilm morphology. In our simulations, which generalize the PLHmodel by treating cells as spatially extended, deformable bodies, differentialadhesion between cells, and their competition for a substrate (nutrient), sufficeto produce a fingering instability that generates the finger shapes of biofilms.Our results agree with most features of the PLH model, although our inclu-sion of cell adhesion, which is difficult to implement using other modelingapproaches, results in slightly different patterns. Our simulations thus pro-vide the groundwork for simulations of medically and industrially importantmultispecies biofilms. |
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| ISSN: | 1551-0018 |