Impact of Ramadan Intermittent Fasting on Oxidative Stress Measured by Urinary 15-F2t-Isoprostane
Fasting and caloric restriction have been associated with reduced incidence of chronic diseases and cancers. These effects have been attributed to reduced oxidative stress. Since Ramadan intermittent fasting (RIF) has been associated with reduced caloric intake, it was hypothesized that RIF would al...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Journal of Nutrition and Metabolism |
| Online Access: | http://dx.doi.org/10.1155/2012/802924 |
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| author | Mo'ez Al-Islam Ezzat Faris Rand Nidal Hussein Ref'at Ahmad Al-Kurd Mohammed Ahmed Al-Fararjeh Yasser Khalil Bustanji Mohammad Khalil Mohammad |
| author_facet | Mo'ez Al-Islam Ezzat Faris Rand Nidal Hussein Ref'at Ahmad Al-Kurd Mohammed Ahmed Al-Fararjeh Yasser Khalil Bustanji Mohammad Khalil Mohammad |
| author_sort | Mo'ez Al-Islam Ezzat Faris |
| collection | DOAJ |
| description | Fasting and caloric restriction have been associated with reduced incidence of chronic diseases and cancers. These effects have been attributed to reduced oxidative stress. Since Ramadan intermittent fasting (RIF) has been associated with reduced caloric intake, it was hypothesized that RIF would alleviate oxidative stress in healthy volunteers. The study was designed to elucidate the impact of RIF on oxidative stress measured by 15-F2t-Isoprostane (15FIP). Fifty healthy subjects (23 men and 27 women) who intended to
fast Ramadan were recruited. Urine and serum sampling and anthropometric and dietary assessments were conducted one week before Ramadan (T0), at the end of the third week of Ramadan (T1), and one month after Ramadan (T2). Biochemical measurements included urinary 15FIP, creatinine, and hematological indices. Results revealed that the urinary level of 15FIP measured at T0 was normal, while they showed a significantly (P<0.05) higher level when measured at T1 concomitant with a significant (P<0.05) increase in the body weight and total body fat percent. In conclusion, results suggest that increased body weight is associated with increased lipid peroxidation and oxidative stress, and the impact of RIF on oxidative stress is mediated by the changes in body weight at the end of the month. |
| format | Article |
| id | doaj-art-373e9e2b6d5046e1823efe57b10d9948 |
| institution | Kabale University |
| issn | 2090-0724 2090-0732 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Nutrition and Metabolism |
| spelling | doaj-art-373e9e2b6d5046e1823efe57b10d99482025-02-03T05:46:23ZengWileyJournal of Nutrition and Metabolism2090-07242090-07322012-01-01201210.1155/2012/802924802924Impact of Ramadan Intermittent Fasting on Oxidative Stress Measured by Urinary 15-F2t-IsoprostaneMo'ez Al-Islam Ezzat Faris0Rand Nidal Hussein1Ref'at Ahmad Al-Kurd2Mohammed Ahmed Al-Fararjeh3Yasser Khalil Bustanji4Mohammad Khalil Mohammad5Department of Clinical Nutrition, College of Applied Medical Sciences, University of Hail, P.O. Box 2440, Hail, Saudi ArabiaDepartment of Clinical Pharmacy and Biopharmaceutics, Faculty of Pharmacy, The University of Jordan, P.O. Box 11942, Amman, JordanDepartment of Nutrition, Faculty of Pharmacy and Medical Sciences, Petra University, P.O. Box 961343, Amman, JordanDepartment of Medical Laboratory Sciences, Faculty of Allied Health Sciences, The Hashemite University, P.O. Box 591504, Zarqa, JordanDepartment of Clinical Pharmacy and Biopharmaceutics, Faculty of Pharmacy, The University of Jordan, P.O. Box 11942, Amman, JordanDepartment of Clinical Pharmacy and Biopharmaceutics, Faculty of Pharmacy, The University of Jordan, P.O. Box 11942, Amman, JordanFasting and caloric restriction have been associated with reduced incidence of chronic diseases and cancers. These effects have been attributed to reduced oxidative stress. Since Ramadan intermittent fasting (RIF) has been associated with reduced caloric intake, it was hypothesized that RIF would alleviate oxidative stress in healthy volunteers. The study was designed to elucidate the impact of RIF on oxidative stress measured by 15-F2t-Isoprostane (15FIP). Fifty healthy subjects (23 men and 27 women) who intended to fast Ramadan were recruited. Urine and serum sampling and anthropometric and dietary assessments were conducted one week before Ramadan (T0), at the end of the third week of Ramadan (T1), and one month after Ramadan (T2). Biochemical measurements included urinary 15FIP, creatinine, and hematological indices. Results revealed that the urinary level of 15FIP measured at T0 was normal, while they showed a significantly (P<0.05) higher level when measured at T1 concomitant with a significant (P<0.05) increase in the body weight and total body fat percent. In conclusion, results suggest that increased body weight is associated with increased lipid peroxidation and oxidative stress, and the impact of RIF on oxidative stress is mediated by the changes in body weight at the end of the month.http://dx.doi.org/10.1155/2012/802924 |
| spellingShingle | Mo'ez Al-Islam Ezzat Faris Rand Nidal Hussein Ref'at Ahmad Al-Kurd Mohammed Ahmed Al-Fararjeh Yasser Khalil Bustanji Mohammad Khalil Mohammad Impact of Ramadan Intermittent Fasting on Oxidative Stress Measured by Urinary 15-F2t-Isoprostane Journal of Nutrition and Metabolism |
| title | Impact of Ramadan Intermittent Fasting on Oxidative Stress Measured by Urinary 15-F2t-Isoprostane |
| title_full | Impact of Ramadan Intermittent Fasting on Oxidative Stress Measured by Urinary 15-F2t-Isoprostane |
| title_fullStr | Impact of Ramadan Intermittent Fasting on Oxidative Stress Measured by Urinary 15-F2t-Isoprostane |
| title_full_unstemmed | Impact of Ramadan Intermittent Fasting on Oxidative Stress Measured by Urinary 15-F2t-Isoprostane |
| title_short | Impact of Ramadan Intermittent Fasting on Oxidative Stress Measured by Urinary 15-F2t-Isoprostane |
| title_sort | impact of ramadan intermittent fasting on oxidative stress measured by urinary 15 f2t isoprostane |
| url | http://dx.doi.org/10.1155/2012/802924 |
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