Association between angiotensinogen M235T gene polymorphism and risk of ischemic stroke among the Ethiopian population: a case control study
Ischemic stroke (IS) is a multifaceted, complicated illness resulting from a confluence of genetic, environmental and vascular risk factors. Many genes that may contribute to ischemic stroke have been discovered in humans. The genetic contribution appears to be greater in IS patients with hypertensi...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2023-03-01
|
| Series: | Biotechnology & Biotechnological Equipment |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/13102818.2023.2190414 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850063868819144704 |
|---|---|
| author | Addisu Melake Marye Alemu Nega Berhane |
| author_facet | Addisu Melake Marye Alemu Nega Berhane |
| author_sort | Addisu Melake |
| collection | DOAJ |
| description | Ischemic stroke (IS) is a multifaceted, complicated illness resulting from a confluence of genetic, environmental and vascular risk factors. Many genes that may contribute to ischemic stroke have been discovered in humans. The genetic contribution appears to be greater in IS patients with hypertension. There is conflicting evidence about a positive correlation between the AGT M235T polymorphism and ischemic stroke. The aim of this study was to examine the possible association of the AGT M235T gene polymorphism with the risk of ischemic stroke. A hospital-based case-control study was carried out in 36 ischemic stroke patient cases and 36 age- and sex-matched healthy controls. Clinical parameters were measured to assess the associated risk factors. DNA was isolated from blood samples, and the AGT M235T genotypes were identified using polymerase chain reaction (PCR) and analyzed by agarose gel electrophoresis. The AGT-TT genotype (OR = 4.64, 95% CL = 1.23–17.4; p = 0.023 and T allele (OR = 2.54, 95% CL = 1.28–5.02; p = 0.003) were significantly more common in patients than in controls, indicating that it may be a major risk factor for the development of ischemic stroke. The results suggest that there may be a significant correlation between the AGT M235T gene polymorphism and the development of ischemic stroke in the studied Ethiopian population. |
| format | Article |
| id | doaj-art-372b0dcfe2dc4c82b636d100d2dacfa5 |
| institution | DOAJ |
| issn | 1310-2818 1314-3530 |
| language | English |
| publishDate | 2023-03-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Biotechnology & Biotechnological Equipment |
| spelling | doaj-art-372b0dcfe2dc4c82b636d100d2dacfa52025-08-20T02:49:29ZengTaylor & Francis GroupBiotechnology & Biotechnological Equipment1310-28181314-35302023-03-0137130230810.1080/13102818.2023.2190414Association between angiotensinogen M235T gene polymorphism and risk of ischemic stroke among the Ethiopian population: a case control studyAddisu Melake0Marye Alemu1Nega Berhane2Department of Biomedical Science, College of Health Science, Debre Tabor University, Debre Tabor, EthiopiaDepartment of Medical Biotechnology, Institute of Biotechnology, University of Gondar, Gondar, EthiopiaDepartment of Medical Biotechnology, Institute of Biotechnology, University of Gondar, Gondar, EthiopiaIschemic stroke (IS) is a multifaceted, complicated illness resulting from a confluence of genetic, environmental and vascular risk factors. Many genes that may contribute to ischemic stroke have been discovered in humans. The genetic contribution appears to be greater in IS patients with hypertension. There is conflicting evidence about a positive correlation between the AGT M235T polymorphism and ischemic stroke. The aim of this study was to examine the possible association of the AGT M235T gene polymorphism with the risk of ischemic stroke. A hospital-based case-control study was carried out in 36 ischemic stroke patient cases and 36 age- and sex-matched healthy controls. Clinical parameters were measured to assess the associated risk factors. DNA was isolated from blood samples, and the AGT M235T genotypes were identified using polymerase chain reaction (PCR) and analyzed by agarose gel electrophoresis. The AGT-TT genotype (OR = 4.64, 95% CL = 1.23–17.4; p = 0.023 and T allele (OR = 2.54, 95% CL = 1.28–5.02; p = 0.003) were significantly more common in patients than in controls, indicating that it may be a major risk factor for the development of ischemic stroke. The results suggest that there may be a significant correlation between the AGT M235T gene polymorphism and the development of ischemic stroke in the studied Ethiopian population.https://www.tandfonline.com/doi/10.1080/13102818.2023.2190414Angiotensinogenclinical risk factorsgenotypeischemic stroke |
| spellingShingle | Addisu Melake Marye Alemu Nega Berhane Association between angiotensinogen M235T gene polymorphism and risk of ischemic stroke among the Ethiopian population: a case control study Biotechnology & Biotechnological Equipment Angiotensinogen clinical risk factors genotype ischemic stroke |
| title | Association between angiotensinogen M235T gene polymorphism and risk of ischemic stroke among the Ethiopian population: a case control study |
| title_full | Association between angiotensinogen M235T gene polymorphism and risk of ischemic stroke among the Ethiopian population: a case control study |
| title_fullStr | Association between angiotensinogen M235T gene polymorphism and risk of ischemic stroke among the Ethiopian population: a case control study |
| title_full_unstemmed | Association between angiotensinogen M235T gene polymorphism and risk of ischemic stroke among the Ethiopian population: a case control study |
| title_short | Association between angiotensinogen M235T gene polymorphism and risk of ischemic stroke among the Ethiopian population: a case control study |
| title_sort | association between angiotensinogen m235t gene polymorphism and risk of ischemic stroke among the ethiopian population a case control study |
| topic | Angiotensinogen clinical risk factors genotype ischemic stroke |
| url | https://www.tandfonline.com/doi/10.1080/13102818.2023.2190414 |
| work_keys_str_mv | AT addisumelake associationbetweenangiotensinogenm235tgenepolymorphismandriskofischemicstrokeamongtheethiopianpopulationacasecontrolstudy AT maryealemu associationbetweenangiotensinogenm235tgenepolymorphismandriskofischemicstrokeamongtheethiopianpopulationacasecontrolstudy AT negaberhane associationbetweenangiotensinogenm235tgenepolymorphismandriskofischemicstrokeamongtheethiopianpopulationacasecontrolstudy |