The Decreased Growth Hormone Response to Growth Hormone Releasing Hormone in Obesity Is Associated to Cardiometabolic Risk Factors
The aim of the present study was to evaluate the relationship between GHRH-induced GH secretion in obese premenopausal women and cardiovascular risk markers or insulin resistance. Premenopausal obese women, aged 35–52 years, were studied. GH secretion, IGF-I, serum cardiovascular risk markers, insul...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2010/434562 |
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| author | Fernando Cordido Jesús Garcia-Buela Susana Sangiao-Alvarellos Teresa Martinez Ovidio Vidal |
| author_facet | Fernando Cordido Jesús Garcia-Buela Susana Sangiao-Alvarellos Teresa Martinez Ovidio Vidal |
| author_sort | Fernando Cordido |
| collection | DOAJ |
| description | The aim of the present study was to evaluate the relationship between GHRH-induced GH secretion in obese premenopausal women and cardiovascular risk markers or insulin resistance.
Premenopausal obese women, aged 35–52 years, were studied. GH secretion, IGF-I, serum cardiovascular risk markers, insulin, leptin, mid-waist and hip circumference, total body fat, and truncal fat were measured. Subjects were classified as meeting the criteria for GH deficiency (GHD) when peak GH after stimulation with GHRH was ≤3 μg/L. Mean total and LDL cholesterol, fasting insulin, and HOMA-IR were all higher, in subjects who would have been classified as GH-deficient compared with GH-sufficient. Peak GH secretion after stimulation was inversely associated with fasting insulin (R=−0.650, P=.012), HOMA-IR (R=−0.846, P=.001), total cholesterol (R=−0.532, P=.034), and LDL cholesterol (R=−0.692, P=.006) and positively associated with HDL cholesterol (R=0.561, P=.037).
These data strongly suggest a role for insulin resistance in the decreased GH secretion of obesity and that the blunted GH secretion of central obesity could be the pituitary expression of the metabolic syndrome. |
| format | Article |
| id | doaj-art-372a4a0da6214864b5d14da6ade4bbdc |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-372a4a0da6214864b5d14da6ade4bbdc2025-02-03T01:11:38ZengWileyMediators of Inflammation0962-93511466-18612010-01-01201010.1155/2010/434562434562The Decreased Growth Hormone Response to Growth Hormone Releasing Hormone in Obesity Is Associated to Cardiometabolic Risk FactorsFernando Cordido0Jesús Garcia-Buela1Susana Sangiao-Alvarellos2Teresa Martinez3Ovidio Vidal4Department of Endocrinology, Hospital A Coruña, 15006 A Coruña, SpainDepartment of Laboratory, Hospital A Coruña, 15006 A Coruña, SpainDepartment of Investigation, Hospital A Coruña, 15006 A Coruña, SpainDepartment of Endocrinology, Hospital A Coruña, 15006 A Coruña, SpainDepartment of Endocrinology, Hospital A Coruña, 15006 A Coruña, SpainThe aim of the present study was to evaluate the relationship between GHRH-induced GH secretion in obese premenopausal women and cardiovascular risk markers or insulin resistance. Premenopausal obese women, aged 35–52 years, were studied. GH secretion, IGF-I, serum cardiovascular risk markers, insulin, leptin, mid-waist and hip circumference, total body fat, and truncal fat were measured. Subjects were classified as meeting the criteria for GH deficiency (GHD) when peak GH after stimulation with GHRH was ≤3 μg/L. Mean total and LDL cholesterol, fasting insulin, and HOMA-IR were all higher, in subjects who would have been classified as GH-deficient compared with GH-sufficient. Peak GH secretion after stimulation was inversely associated with fasting insulin (R=−0.650, P=.012), HOMA-IR (R=−0.846, P=.001), total cholesterol (R=−0.532, P=.034), and LDL cholesterol (R=−0.692, P=.006) and positively associated with HDL cholesterol (R=0.561, P=.037). These data strongly suggest a role for insulin resistance in the decreased GH secretion of obesity and that the blunted GH secretion of central obesity could be the pituitary expression of the metabolic syndrome.http://dx.doi.org/10.1155/2010/434562 |
| spellingShingle | Fernando Cordido Jesús Garcia-Buela Susana Sangiao-Alvarellos Teresa Martinez Ovidio Vidal The Decreased Growth Hormone Response to Growth Hormone Releasing Hormone in Obesity Is Associated to Cardiometabolic Risk Factors Mediators of Inflammation |
| title | The Decreased Growth Hormone Response to Growth Hormone Releasing Hormone in Obesity Is Associated to Cardiometabolic Risk Factors |
| title_full | The Decreased Growth Hormone Response to Growth Hormone Releasing Hormone in Obesity Is Associated to Cardiometabolic Risk Factors |
| title_fullStr | The Decreased Growth Hormone Response to Growth Hormone Releasing Hormone in Obesity Is Associated to Cardiometabolic Risk Factors |
| title_full_unstemmed | The Decreased Growth Hormone Response to Growth Hormone Releasing Hormone in Obesity Is Associated to Cardiometabolic Risk Factors |
| title_short | The Decreased Growth Hormone Response to Growth Hormone Releasing Hormone in Obesity Is Associated to Cardiometabolic Risk Factors |
| title_sort | decreased growth hormone response to growth hormone releasing hormone in obesity is associated to cardiometabolic risk factors |
| url | http://dx.doi.org/10.1155/2010/434562 |
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