Anti-Yo Mediated Paraneoplastic Cerebellar Degeneration Associated with Pseudobulbar Affect in a Patient with Breast Cancer
Paraneoplastic cerebellar degeneration (PCD) is a rare anti-Yo mediated paraneoplastic syndromes rarely that is infrequently associated with breast cancer. We present a case of a 52-year-old female presenting with diplopia, gait instability, dysarthria, dysphagia, nystagmus, and, most notably, new o...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2017-01-01
|
| Series: | Case Reports in Oncological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2017/8120689 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832554626119892992 |
|---|---|
| author | Allison N. Martin Patrick M. Dillon David E. Jones David R. Brenin David A. Lapides |
| author_facet | Allison N. Martin Patrick M. Dillon David E. Jones David R. Brenin David A. Lapides |
| author_sort | Allison N. Martin |
| collection | DOAJ |
| description | Paraneoplastic cerebellar degeneration (PCD) is a rare anti-Yo mediated paraneoplastic syndromes rarely that is infrequently associated with breast cancer. We present a case of a 52-year-old female presenting with diplopia, gait instability, dysarthria, dysphagia, nystagmus, and, most notably, new onset paroxysmal episodes of uncontrollable crying concerning for pseudobulbar affect (PBA). Serologic testing showed anti-Yo antibodies. The patient was found to have stage IIIA breast cancer as the inciting cause of the paraneoplastic syndrome. The patient was treated with neoadjuvant chemotherapy, modified radical mastectomy, adjuvant Herceptin, and pertuzumab. She was given IVIG for paraneoplastic syndrome, antidepressants, and dextromethorphan-quinidine (Nuedexta), the first FDA-approved therapy for PBA. With multimodality therapy, she demonstrated significant improvement in neurologic and mood symptoms associated with PCD and PBA. |
| format | Article |
| id | doaj-art-3728b19758c0486c80f25534650ba2c2 |
| institution | Kabale University |
| issn | 2090-6706 2090-6714 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Oncological Medicine |
| spelling | doaj-art-3728b19758c0486c80f25534650ba2c22025-02-03T05:50:58ZengWileyCase Reports in Oncological Medicine2090-67062090-67142017-01-01201710.1155/2017/81206898120689Anti-Yo Mediated Paraneoplastic Cerebellar Degeneration Associated with Pseudobulbar Affect in a Patient with Breast CancerAllison N. Martin0Patrick M. Dillon1David E. Jones2David R. Brenin3David A. Lapides4Department of Surgery, University of Virginia, Charlottesville, VA, USADepartment of Medicine, University of Virginia, Charlottesville, VA, USADepartment of Neurology, University of Virginia, Charlottesville, VA, USADepartment of Surgery, University of Virginia, Charlottesville, VA, USADepartment of Neurology, University of Virginia, Charlottesville, VA, USAParaneoplastic cerebellar degeneration (PCD) is a rare anti-Yo mediated paraneoplastic syndromes rarely that is infrequently associated with breast cancer. We present a case of a 52-year-old female presenting with diplopia, gait instability, dysarthria, dysphagia, nystagmus, and, most notably, new onset paroxysmal episodes of uncontrollable crying concerning for pseudobulbar affect (PBA). Serologic testing showed anti-Yo antibodies. The patient was found to have stage IIIA breast cancer as the inciting cause of the paraneoplastic syndrome. The patient was treated with neoadjuvant chemotherapy, modified radical mastectomy, adjuvant Herceptin, and pertuzumab. She was given IVIG for paraneoplastic syndrome, antidepressants, and dextromethorphan-quinidine (Nuedexta), the first FDA-approved therapy for PBA. With multimodality therapy, she demonstrated significant improvement in neurologic and mood symptoms associated with PCD and PBA.http://dx.doi.org/10.1155/2017/8120689 |
| spellingShingle | Allison N. Martin Patrick M. Dillon David E. Jones David R. Brenin David A. Lapides Anti-Yo Mediated Paraneoplastic Cerebellar Degeneration Associated with Pseudobulbar Affect in a Patient with Breast Cancer Case Reports in Oncological Medicine |
| title | Anti-Yo Mediated Paraneoplastic Cerebellar Degeneration Associated with Pseudobulbar Affect in a Patient with Breast Cancer |
| title_full | Anti-Yo Mediated Paraneoplastic Cerebellar Degeneration Associated with Pseudobulbar Affect in a Patient with Breast Cancer |
| title_fullStr | Anti-Yo Mediated Paraneoplastic Cerebellar Degeneration Associated with Pseudobulbar Affect in a Patient with Breast Cancer |
| title_full_unstemmed | Anti-Yo Mediated Paraneoplastic Cerebellar Degeneration Associated with Pseudobulbar Affect in a Patient with Breast Cancer |
| title_short | Anti-Yo Mediated Paraneoplastic Cerebellar Degeneration Associated with Pseudobulbar Affect in a Patient with Breast Cancer |
| title_sort | anti yo mediated paraneoplastic cerebellar degeneration associated with pseudobulbar affect in a patient with breast cancer |
| url | http://dx.doi.org/10.1155/2017/8120689 |
| work_keys_str_mv | AT allisonnmartin antiyomediatedparaneoplasticcerebellardegenerationassociatedwithpseudobulbaraffectinapatientwithbreastcancer AT patrickmdillon antiyomediatedparaneoplasticcerebellardegenerationassociatedwithpseudobulbaraffectinapatientwithbreastcancer AT davidejones antiyomediatedparaneoplasticcerebellardegenerationassociatedwithpseudobulbaraffectinapatientwithbreastcancer AT davidrbrenin antiyomediatedparaneoplasticcerebellardegenerationassociatedwithpseudobulbaraffectinapatientwithbreastcancer AT davidalapides antiyomediatedparaneoplasticcerebellardegenerationassociatedwithpseudobulbaraffectinapatientwithbreastcancer |