Study on the extraction of flavonoids from Artemisia integrifolia and its anti-lung cancer activity
Objective: To extract flavonoids from Artemisia integrifolia and determine their content, to evaluate their activity. Method: Total flavonoids were extracted using ultrasonic extraction, and the inhibitory effect on the proliferation of lung cancer cells H1299 was investigated. Additionally, a preli...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
EDP Sciences
2025-01-01
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| Series: | BIO Web of Conferences |
| Online Access: | https://www.bio-conferences.org/articles/bioconf/pdf/2025/33/bioconf_icfsb2025_01011.pdf |
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| Summary: | Objective: To extract flavonoids from Artemisia integrifolia and determine their content, to evaluate their activity. Method: Total flavonoids were extracted using ultrasonic extraction, and the inhibitory effect on the proliferation of lung cancer cells H1299 was investigated. Additionally, a preliminary study was conducted on the treatment of liver degeneration. Results: Using a 50% ethanol solution, ultrasonic treatment at 90°C for 50 minutes followed by reflux for 3 hours resulted in the highest total flavonoid extraction rate. The study showed that it has a certain inhibitory effect on the proliferation of lung cancer H1299 cells, with an IC50 value of approximately 200μg/mL measured by MTT assay. The treatment also showed therapeutic effects on liver degeneration. |
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| ISSN: | 2117-4458 |