3D-printed gallium-infused scaffolds for osteolysis intervention and bone regeneration
Exacerbation of osteolysis in osteoporotic bone defects presents a significant challenge for implant-based treatments. This underscores the urgent need to develop implants that actively mitigate osteolysis while simultaneously promoting bone regeneration. In this study, the osteogenic potential of m...
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Elsevier
2025-04-01
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| Series: | Materials Today Bio |
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| author | Hanrui Xi Xihao Jiang Shilang Xiong Yinuo Zhang Jingyu Zhou Min Liu Zhigang Zhou Chengyu Zhang Shiwei Liu Zhisheng Long Jianguo Zhou Guowen Qian Long Xiong |
| author_facet | Hanrui Xi Xihao Jiang Shilang Xiong Yinuo Zhang Jingyu Zhou Min Liu Zhigang Zhou Chengyu Zhang Shiwei Liu Zhisheng Long Jianguo Zhou Guowen Qian Long Xiong |
| author_sort | Hanrui Xi |
| collection | DOAJ |
| description | Exacerbation of osteolysis in osteoporotic bone defects presents a significant challenge for implant-based treatments. This underscores the urgent need to develop implants that actively mitigate osteolysis while simultaneously promoting bone regeneration. In this study, the osteogenic potential of mesoporous bioactive glass (MBG) and β-tricalcium phosphate (β-TCP) was combined with the anti-bone resorption property of Ga doping. Ga-MBG was synthesized using a self-transformation method and subsequently incorporated into β-TCP at concentrations of 5 wt%, 10 wt% and 15 wt%. Scaffolds were prepared using extrusion-based 3D printing. The cytocompatibility of the composite scaffolds and their regulatory effects on the differentiation of osteoblasts and osteoclasts were systematically examined. In addition, the molecular mechanisms underlying bone regeneration and osteolysis regulation in osteoblasts were explored. Subsequently, cranial defects were repaired in a rat model of osteoporosis to assess the therapeutic efficacy and biological safety of the optimal concentration of the Ga-MBG/TCP composite scaffold. These findings indicated that the 10 wt% Ga-MBG/TCP composite scaffold exhibited excellent biocompatibility, enhanced new bone formation, and effectively mitigated osteolysis. These results provide a foundation for further investigation into the optimal concentration of Ga-MBG implants and highlight their potential application in future therapies for osteoporotic bone defects. |
| format | Article |
| id | doaj-art-37123cfd67174193829baa157290aa33 |
| institution | Kabale University |
| issn | 2590-0064 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj-art-37123cfd67174193829baa157290aa332025-02-03T04:16:53ZengElsevierMaterials Today Bio2590-00642025-04-01311015243D-printed gallium-infused scaffolds for osteolysis intervention and bone regenerationHanrui Xi0Xihao Jiang1Shilang Xiong2Yinuo Zhang3Jingyu Zhou4Min Liu5Zhigang Zhou6Chengyu Zhang7Shiwei Liu8Zhisheng Long9Jianguo Zhou10Guowen Qian11Long Xiong12Department of Orthopedics, Second Affiliated Hospital of Nanchang University, NO. 1 Minde Road, Nanchang, Jiangxi, 330006, China; Institute of Clinical Medicine, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi, 330006, ChinaSchool of Energy and Mechanical Engineering, Jiangxi University of Science and Technology, No. 1180 Shuanggang East Avenue, Nanchang, Jiangxi, 330013, ChinaDepartment of Orthopedics, Tenth People's Hospital of Tongji University, Shanghai, 200072, ChinaDepartment of Orthopedics, Huashan Hospital, Fudan University, Shanghai, 200040, ChinaDepartment of Orthopedics, Second Affiliated Hospital of Nanchang University, NO. 1 Minde Road, Nanchang, Jiangxi, 330006, China; Institute of Clinical Medicine, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi, 330006, ChinaDepartment of Orthopedics, Second Affiliated Hospital of Nanchang University, NO. 1 Minde Road, Nanchang, Jiangxi, 330006, China; Institute of Clinical Medicine, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi, 330006, ChinaDepartment of Orthopedics, Second Affiliated Hospital of Nanchang University, NO. 1 Minde Road, Nanchang, Jiangxi, 330006, China; Institute of Clinical Medicine, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi, 330006, ChinaDepartment of Orthopedics, Second Affiliated Hospital of Nanchang University, NO. 1 Minde Road, Nanchang, Jiangxi, 330006, ChinaDepartment of Joint Surgery, Ganzhou People's Hospital, No. 16, Mei Guan Road, Zhang Gong District, Ganzhou, Jiangxi, 341000, ChinaInstitute of Clinical Medicine, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi, 330006, China; Department of Orthopedic, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi, 330006, ChinaDepartment of Joint Surgery, Ganzhou People's Hospital, No. 16, Mei Guan Road, Zhang Gong District, Ganzhou, Jiangxi, 341000, China; Corresponding author. Department of Orthopedics, Ganzhou People's Hospital, No. 16, Mei Guan Road, Zhang Gong District, Ganzhou, Jiangxi, 341000, China.School of Energy and Mechanical Engineering, Jiangxi University of Science and Technology, No. 1180 Shuanggang East Avenue, Nanchang, Jiangxi, 330013, China; Corresponding author. School of Energy and Mechanical Engineering, Jiangxi University of Science and Technology, Nanchang, Jiangxi, 330013, China.Department of Orthopedics, Second Affiliated Hospital of Nanchang University, NO. 1 Minde Road, Nanchang, Jiangxi, 330006, China; Institute of Orthopedics of Jiangxi Province, Nanchang, Jiangxi, 330006, China; Jiangxi Provincial Key Laboratory of Spine and Spinal Cord Disease, Jiangxi, 330006, China; Institute of Minimally Invasive Orthopedics, Nanchang University, Jiangxi, 330006, China; Corresponding author. Department of Orthopedics, Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, 330006, China.Exacerbation of osteolysis in osteoporotic bone defects presents a significant challenge for implant-based treatments. This underscores the urgent need to develop implants that actively mitigate osteolysis while simultaneously promoting bone regeneration. In this study, the osteogenic potential of mesoporous bioactive glass (MBG) and β-tricalcium phosphate (β-TCP) was combined with the anti-bone resorption property of Ga doping. Ga-MBG was synthesized using a self-transformation method and subsequently incorporated into β-TCP at concentrations of 5 wt%, 10 wt% and 15 wt%. Scaffolds were prepared using extrusion-based 3D printing. The cytocompatibility of the composite scaffolds and their regulatory effects on the differentiation of osteoblasts and osteoclasts were systematically examined. In addition, the molecular mechanisms underlying bone regeneration and osteolysis regulation in osteoblasts were explored. Subsequently, cranial defects were repaired in a rat model of osteoporosis to assess the therapeutic efficacy and biological safety of the optimal concentration of the Ga-MBG/TCP composite scaffold. These findings indicated that the 10 wt% Ga-MBG/TCP composite scaffold exhibited excellent biocompatibility, enhanced new bone formation, and effectively mitigated osteolysis. These results provide a foundation for further investigation into the optimal concentration of Ga-MBG implants and highlight their potential application in future therapies for osteoporotic bone defects.http://www.sciencedirect.com/science/article/pii/S2590006425000821Gallium dopingMesoporous bioglassTricalcium phosphateOsteoporosisBone regeneration |
| spellingShingle | Hanrui Xi Xihao Jiang Shilang Xiong Yinuo Zhang Jingyu Zhou Min Liu Zhigang Zhou Chengyu Zhang Shiwei Liu Zhisheng Long Jianguo Zhou Guowen Qian Long Xiong 3D-printed gallium-infused scaffolds for osteolysis intervention and bone regeneration Materials Today Bio Gallium doping Mesoporous bioglass Tricalcium phosphate Osteoporosis Bone regeneration |
| title | 3D-printed gallium-infused scaffolds for osteolysis intervention and bone regeneration |
| title_full | 3D-printed gallium-infused scaffolds for osteolysis intervention and bone regeneration |
| title_fullStr | 3D-printed gallium-infused scaffolds for osteolysis intervention and bone regeneration |
| title_full_unstemmed | 3D-printed gallium-infused scaffolds for osteolysis intervention and bone regeneration |
| title_short | 3D-printed gallium-infused scaffolds for osteolysis intervention and bone regeneration |
| title_sort | 3d printed gallium infused scaffolds for osteolysis intervention and bone regeneration |
| topic | Gallium doping Mesoporous bioglass Tricalcium phosphate Osteoporosis Bone regeneration |
| url | http://www.sciencedirect.com/science/article/pii/S2590006425000821 |
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