Choline Deficiency Attenuates Body Weight Gain and Improves Glucose Tolerance in ob/ob Mice
Previous studies demonstrated that choline supply is directly linked to high-fat-diet-induced obesity and insulin resistance in mice. The aim of this study was to evaluate if choline supply could also modulate obesity and insulin resistance caused by a genetic defect. Eight-week-old male ob/ob mice...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Journal of Obesity |
| Online Access: | http://dx.doi.org/10.1155/2012/319172 |
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| author | Gengshu Wu Liyan Zhang Tete Li Gary Lopaschuk Dennis E. Vance René L. Jacobs |
| author_facet | Gengshu Wu Liyan Zhang Tete Li Gary Lopaschuk Dennis E. Vance René L. Jacobs |
| author_sort | Gengshu Wu |
| collection | DOAJ |
| description | Previous studies demonstrated that choline supply is directly linked to high-fat-diet-induced obesity and insulin resistance in mice. The aim of this study was to evaluate if choline supply could also modulate obesity and insulin resistance caused by a genetic defect. Eight-week-old male ob/ob mice were fed for two months with either choline-deficient or choline-supplemented diet. Tissue weight including fat mass and lean mass was assessed. Intracellular signaling, plasma glucagon and insulin, and glucose and insulin tolerance tests were also investigated. The choline-deficient diet slowed body weight gain and decreased fat mass. Choline deficiency also decreased plasma glucose level and improved glucose and insulin tolerance although fatty liver was exacerbated. Increased adipose lipolytic activity, decreased plasma glucagon and reduced expression of hepatic glucagon receptor were also observed with the choline-deficient diet. Our results demonstrate that a choline-deficient diet can decrease fat mass and improve glucose tolerance in obese and diabetic mice caused by a genetic defect. |
| format | Article |
| id | doaj-art-370f307f547f44f180d46e8cb91d9484 |
| institution | Kabale University |
| issn | 2090-0708 2090-0716 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Obesity |
| spelling | doaj-art-370f307f547f44f180d46e8cb91d94842025-02-03T06:44:18ZengWileyJournal of Obesity2090-07082090-07162012-01-01201210.1155/2012/319172319172Choline Deficiency Attenuates Body Weight Gain and Improves Glucose Tolerance in ob/ob MiceGengshu Wu0Liyan Zhang1Tete Li2Gary Lopaschuk3Dennis E. Vance4René L. Jacobs5Group on the Molecular and Cell Biology of Lipids and Department of Biochemistry, University of Alberta, Edmonton, AB, T6G 2S2, CanadaCardiovascular Research Group, University of Alberta, Edmonton, AB, T6G 2S2, CanadaGroup on the Molecular and Cell Biology of Lipids and Department of Biochemistry, University of Alberta, Edmonton, AB, T6G 2S2, CanadaCardiovascular Research Group, University of Alberta, Edmonton, AB, T6G 2S2, CanadaGroup on the Molecular and Cell Biology of Lipids and Department of Biochemistry, University of Alberta, Edmonton, AB, T6G 2S2, CanadaDepartment of Agricultural, Food and Nutritional Sciences, University of Alberta, Edmonton, AB, T6G 2S2, CanadaPrevious studies demonstrated that choline supply is directly linked to high-fat-diet-induced obesity and insulin resistance in mice. The aim of this study was to evaluate if choline supply could also modulate obesity and insulin resistance caused by a genetic defect. Eight-week-old male ob/ob mice were fed for two months with either choline-deficient or choline-supplemented diet. Tissue weight including fat mass and lean mass was assessed. Intracellular signaling, plasma glucagon and insulin, and glucose and insulin tolerance tests were also investigated. The choline-deficient diet slowed body weight gain and decreased fat mass. Choline deficiency also decreased plasma glucose level and improved glucose and insulin tolerance although fatty liver was exacerbated. Increased adipose lipolytic activity, decreased plasma glucagon and reduced expression of hepatic glucagon receptor were also observed with the choline-deficient diet. Our results demonstrate that a choline-deficient diet can decrease fat mass and improve glucose tolerance in obese and diabetic mice caused by a genetic defect.http://dx.doi.org/10.1155/2012/319172 |
| spellingShingle | Gengshu Wu Liyan Zhang Tete Li Gary Lopaschuk Dennis E. Vance René L. Jacobs Choline Deficiency Attenuates Body Weight Gain and Improves Glucose Tolerance in ob/ob Mice Journal of Obesity |
| title | Choline Deficiency Attenuates Body Weight Gain and Improves Glucose Tolerance in ob/ob Mice |
| title_full | Choline Deficiency Attenuates Body Weight Gain and Improves Glucose Tolerance in ob/ob Mice |
| title_fullStr | Choline Deficiency Attenuates Body Weight Gain and Improves Glucose Tolerance in ob/ob Mice |
| title_full_unstemmed | Choline Deficiency Attenuates Body Weight Gain and Improves Glucose Tolerance in ob/ob Mice |
| title_short | Choline Deficiency Attenuates Body Weight Gain and Improves Glucose Tolerance in ob/ob Mice |
| title_sort | choline deficiency attenuates body weight gain and improves glucose tolerance in ob ob mice |
| url | http://dx.doi.org/10.1155/2012/319172 |
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