The Relevance of Interventional Time and Clinical Outcomes in Patients with NSTEMI Based on the GRACE Score
Objective. To investigate the relevance between interventional time and clinical outcomes in non-ST-elevation myocardial infarction (NSTEMI) patients of different risk stratifications, which were divided into different groups according to GRACE scores and the time from admission to percutaneous coro...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Applied Bionics and Biomechanics |
| Online Access: | http://dx.doi.org/10.1155/2022/7614619 |
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| author | Ji-Xiang Wang Jing Gao Jian-Yong Xiao Ming-Dong Gao Nan Zhang Peng-Ju Lu Yin Liu |
| author_facet | Ji-Xiang Wang Jing Gao Jian-Yong Xiao Ming-Dong Gao Nan Zhang Peng-Ju Lu Yin Liu |
| author_sort | Ji-Xiang Wang |
| collection | DOAJ |
| description | Objective. To investigate the relevance between interventional time and clinical outcomes in non-ST-elevation myocardial infarction (NSTEMI) patients of different risk stratifications, which were divided into different groups according to GRACE scores and the time from admission to percutaneous coronary intervention (PCI). Method. Patients were grouped according to the GRACE score and the time from admission to intervention therapy. The Cox multivariate risk regression model was used to analyze the correlation between the GRACE score and the time from admission to intervention therapy with major adverse cardiovascular events (MACEs). Cox interactive item regression was also used to investigate the correlation between the time of intervention therapy and GRACE risk stratification with clinical outcomes and to evaluate the efficacy of intervention therapy in different risk stratifications of patients with NSTEMI. Results. Interactive item Cox regression analysis and subgroup analysis show that high-risk NSTEMI patients with a GRACE score>140 points and the time from admission to intervention<24 h (p=0.0004) and 24–72 h (p=0.0143) have interactive effects on the impact of the MACE event with the reference of intervention time>72 h and GRACE score<108 points. The time from admission to intervention<24 h is an independent protective factor for the occurrence of MACE events (HR=0.166, 95% CI 0.052-0.532, p=0.0025). Middle-risk patients with NSTEMI with a GRACE score of 109–140 points and the time from admission to intervention<24 h (p=0.0370) and 24–72 h (p=0.0471) have an interactive effect on the impact of MACE. The time from admission to intervention>72 h is an independent protective factor for the occurrence of MACE (HR=0.201, 95% CI 0.045-0.897, p=0.0355). Conclusion. The time from admission to intervention<24 h could effectively reduce the risk of MACE events within 1 year in high-risk patients with NSTEMI (GRACE score>140 points); the time from admission to intervention>72 h can reduce the risk of MACE events within 1 year in low-risk patients with NSTEMI (GRACE score≤108 points). |
| format | Article |
| id | doaj-art-3702b161638f47a3b5c6897f2d1c20d2 |
| institution | Kabale University |
| issn | 1754-2103 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Applied Bionics and Biomechanics |
| spelling | doaj-art-3702b161638f47a3b5c6897f2d1c20d22025-02-03T01:22:56ZengWileyApplied Bionics and Biomechanics1754-21032022-01-01202210.1155/2022/7614619The Relevance of Interventional Time and Clinical Outcomes in Patients with NSTEMI Based on the GRACE ScoreJi-Xiang Wang0Jing Gao1Jian-Yong Xiao2Ming-Dong Gao3Nan Zhang4Peng-Ju Lu5Yin Liu6Cardiology InstituteInstitute of Cardiovascular DiseasesCardiology InstituteCardiology InstituteCardiology InstituteCardiology InstituteCardiology InstituteObjective. To investigate the relevance between interventional time and clinical outcomes in non-ST-elevation myocardial infarction (NSTEMI) patients of different risk stratifications, which were divided into different groups according to GRACE scores and the time from admission to percutaneous coronary intervention (PCI). Method. Patients were grouped according to the GRACE score and the time from admission to intervention therapy. The Cox multivariate risk regression model was used to analyze the correlation between the GRACE score and the time from admission to intervention therapy with major adverse cardiovascular events (MACEs). Cox interactive item regression was also used to investigate the correlation between the time of intervention therapy and GRACE risk stratification with clinical outcomes and to evaluate the efficacy of intervention therapy in different risk stratifications of patients with NSTEMI. Results. Interactive item Cox regression analysis and subgroup analysis show that high-risk NSTEMI patients with a GRACE score>140 points and the time from admission to intervention<24 h (p=0.0004) and 24–72 h (p=0.0143) have interactive effects on the impact of the MACE event with the reference of intervention time>72 h and GRACE score<108 points. The time from admission to intervention<24 h is an independent protective factor for the occurrence of MACE events (HR=0.166, 95% CI 0.052-0.532, p=0.0025). Middle-risk patients with NSTEMI with a GRACE score of 109–140 points and the time from admission to intervention<24 h (p=0.0370) and 24–72 h (p=0.0471) have an interactive effect on the impact of MACE. The time from admission to intervention>72 h is an independent protective factor for the occurrence of MACE (HR=0.201, 95% CI 0.045-0.897, p=0.0355). Conclusion. The time from admission to intervention<24 h could effectively reduce the risk of MACE events within 1 year in high-risk patients with NSTEMI (GRACE score>140 points); the time from admission to intervention>72 h can reduce the risk of MACE events within 1 year in low-risk patients with NSTEMI (GRACE score≤108 points).http://dx.doi.org/10.1155/2022/7614619 |
| spellingShingle | Ji-Xiang Wang Jing Gao Jian-Yong Xiao Ming-Dong Gao Nan Zhang Peng-Ju Lu Yin Liu The Relevance of Interventional Time and Clinical Outcomes in Patients with NSTEMI Based on the GRACE Score Applied Bionics and Biomechanics |
| title | The Relevance of Interventional Time and Clinical Outcomes in Patients with NSTEMI Based on the GRACE Score |
| title_full | The Relevance of Interventional Time and Clinical Outcomes in Patients with NSTEMI Based on the GRACE Score |
| title_fullStr | The Relevance of Interventional Time and Clinical Outcomes in Patients with NSTEMI Based on the GRACE Score |
| title_full_unstemmed | The Relevance of Interventional Time and Clinical Outcomes in Patients with NSTEMI Based on the GRACE Score |
| title_short | The Relevance of Interventional Time and Clinical Outcomes in Patients with NSTEMI Based on the GRACE Score |
| title_sort | relevance of interventional time and clinical outcomes in patients with nstemi based on the grace score |
| url | http://dx.doi.org/10.1155/2022/7614619 |
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