Role of Nanotechnology in Ischemic Stroke: Advancements in Targeted Therapies and Diagnostics for Enhanced Clinical Outcomes
Each year, the number of cases of strokes and deaths due to this is increasing around the world. This could be due to work stress, lifestyles, unhealthy food habits, and several other reasons. Currently, there are several traditional methods like thrombolysis and mechanical thrombectomy for managing...
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2025-01-01
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| Series: | Journal of Functional Biomaterials |
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| author | Virendra Kumar Yadav Rachna Gupta Abdullah A. Assiri Jalal Uddin Azfar A. Ishaqui Pankaj Kumar Khalid M. Orayj Shazia Tahira Ashish Patel Nisha Choudhary |
| author_facet | Virendra Kumar Yadav Rachna Gupta Abdullah A. Assiri Jalal Uddin Azfar A. Ishaqui Pankaj Kumar Khalid M. Orayj Shazia Tahira Ashish Patel Nisha Choudhary |
| author_sort | Virendra Kumar Yadav |
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| description | Each year, the number of cases of strokes and deaths due to this is increasing around the world. This could be due to work stress, lifestyles, unhealthy food habits, and several other reasons. Currently, there are several traditional methods like thrombolysis and mechanical thrombectomy for managing strokes. The current approach has several limitations, like delayed diagnosis, limited therapeutic delivery, and risks of secondary injuries. So, there is a need for some effective and reliable methods for the management of strokes, which could help in early diagnosis followed by the treatment of strokes. Nanotechnology has played an immense role in managing strokes, and recently, it has emerged as a transformative solution offering innovative diagnostic tools and therapeutic strategies. Nanoparticles (NPs) belonging to several classes, including metallic (metallic and metal oxide), organic (lipids, liposome), and carbon, can cross the blood–brain barrier and may exhibit immense potential for managing various strokes. Moreover, these NPs have exhibited promise in improving imaging specificity and therapeutic delivery by precise drug delivery and real-time monitoring of treatment efficacy. Nanomaterials like cerium oxide (CeO<sub>2</sub>) and liposome-encapsulated agents have neuroprotective properties that reduce oxidative stress and promote neuroregeneration. In the present article, the authors have emphasized the significant advancements in the nanomedicine management of stroke, including NPs-based drug delivery systems, neuroprotective and neuroregenerative therapies, and multimodal imaging advancements. |
| format | Article |
| id | doaj-art-37007299137843d8b43f006d5aad37af |
| institution | Kabale University |
| issn | 2079-4983 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Functional Biomaterials |
| spelling | doaj-art-37007299137843d8b43f006d5aad37af2025-01-24T13:36:05ZengMDPI AGJournal of Functional Biomaterials2079-49832025-01-01161810.3390/jfb16010008Role of Nanotechnology in Ischemic Stroke: Advancements in Targeted Therapies and Diagnostics for Enhanced Clinical OutcomesVirendra Kumar Yadav0Rachna Gupta1Abdullah A. Assiri2Jalal Uddin3Azfar A. Ishaqui4Pankaj Kumar5Khalid M. Orayj6Shazia Tahira7Ashish Patel8Nisha Choudhary9Marwadi University Research Center, Department of Microbiology, Faculty of Sciences, Marwadi University, Rajkot 360003, Gujarat, IndiaDepartment of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad 382021, Gujarat, IndiaDepartment of Clinical Pharmacy, College of Pharmacy, King Khalid University, Abha 61441, Saudi ArabiaDepartment of Pharmaceutical Chemistry, College of Pharmacy, King Khalid University, Abha 61441, Saudi ArabiaDepartment of Clinical Pharmacy, College of Pharmacy, King Khalid University, Abha 61441, Saudi ArabiaDepartment of Environmental Science, Parul Institute of Applied Sciences, Parul University, Vadodara 391760, Gujarat, IndiaDepartment of Clinical Pharmacy, College of Pharmacy, King Khalid University, Abha 61441, Saudi ArabiaInstitute of Professional Psychology, Bahria University Karachi Campus, Karachi 75260, PakistanDepartment of Life Sciences, Hemchandracharya North Gujarat University, Patan 384265, Gujarat, IndiaDepartment of Life Sciences, Hemchandracharya North Gujarat University, Patan 384265, Gujarat, IndiaEach year, the number of cases of strokes and deaths due to this is increasing around the world. This could be due to work stress, lifestyles, unhealthy food habits, and several other reasons. Currently, there are several traditional methods like thrombolysis and mechanical thrombectomy for managing strokes. The current approach has several limitations, like delayed diagnosis, limited therapeutic delivery, and risks of secondary injuries. So, there is a need for some effective and reliable methods for the management of strokes, which could help in early diagnosis followed by the treatment of strokes. Nanotechnology has played an immense role in managing strokes, and recently, it has emerged as a transformative solution offering innovative diagnostic tools and therapeutic strategies. Nanoparticles (NPs) belonging to several classes, including metallic (metallic and metal oxide), organic (lipids, liposome), and carbon, can cross the blood–brain barrier and may exhibit immense potential for managing various strokes. Moreover, these NPs have exhibited promise in improving imaging specificity and therapeutic delivery by precise drug delivery and real-time monitoring of treatment efficacy. Nanomaterials like cerium oxide (CeO<sub>2</sub>) and liposome-encapsulated agents have neuroprotective properties that reduce oxidative stress and promote neuroregeneration. In the present article, the authors have emphasized the significant advancements in the nanomedicine management of stroke, including NPs-based drug delivery systems, neuroprotective and neuroregenerative therapies, and multimodal imaging advancements.https://www.mdpi.com/2079-4983/16/1/8nanomedicinedrug deliverynanomaterialsstrokeblood–brain barrier |
| spellingShingle | Virendra Kumar Yadav Rachna Gupta Abdullah A. Assiri Jalal Uddin Azfar A. Ishaqui Pankaj Kumar Khalid M. Orayj Shazia Tahira Ashish Patel Nisha Choudhary Role of Nanotechnology in Ischemic Stroke: Advancements in Targeted Therapies and Diagnostics for Enhanced Clinical Outcomes Journal of Functional Biomaterials nanomedicine drug delivery nanomaterials stroke blood–brain barrier |
| title | Role of Nanotechnology in Ischemic Stroke: Advancements in Targeted Therapies and Diagnostics for Enhanced Clinical Outcomes |
| title_full | Role of Nanotechnology in Ischemic Stroke: Advancements in Targeted Therapies and Diagnostics for Enhanced Clinical Outcomes |
| title_fullStr | Role of Nanotechnology in Ischemic Stroke: Advancements in Targeted Therapies and Diagnostics for Enhanced Clinical Outcomes |
| title_full_unstemmed | Role of Nanotechnology in Ischemic Stroke: Advancements in Targeted Therapies and Diagnostics for Enhanced Clinical Outcomes |
| title_short | Role of Nanotechnology in Ischemic Stroke: Advancements in Targeted Therapies and Diagnostics for Enhanced Clinical Outcomes |
| title_sort | role of nanotechnology in ischemic stroke advancements in targeted therapies and diagnostics for enhanced clinical outcomes |
| topic | nanomedicine drug delivery nanomaterials stroke blood–brain barrier |
| url | https://www.mdpi.com/2079-4983/16/1/8 |
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