sB7H3 in Children with Acute Appendicitis: Its Diagnostic Value and Association with Histological Findings
Background. Several efforts have been made to find out a valuable marker to assist the diagnosis and differentiation of gangrenous/perforated appendicitis. We aimed to determine the diagnostic capacity of soluble B7H3 (sB7H3) in acute appendicitis (AA) and its accuracy as a predictor of the severity...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2020/2670527 |
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| author | Xiaochen Du Yan Chen Jie Zhu Zhenjiang Bai Jun Hua Ying Li Haitao Lv Guangbo Zhang |
| author_facet | Xiaochen Du Yan Chen Jie Zhu Zhenjiang Bai Jun Hua Ying Li Haitao Lv Guangbo Zhang |
| author_sort | Xiaochen Du |
| collection | DOAJ |
| description | Background. Several efforts have been made to find out a valuable marker to assist the diagnosis and differentiation of gangrenous/perforated appendicitis. We aimed to determine the diagnostic capacity of soluble B7H3 (sB7H3) in acute appendicitis (AA) and its accuracy as a predictor of the severity of appendicitis. Methods. 182 children were allocated into four groups as follows: control group (CG, 90), simple appendicitis (SA, 12), purulent appendicitis (PA, 49), and gangrenous appendicitis (GA, 31). Prior to appendectomy, blood was collected and sent for analysis of routine examination and cytokines (sB7H3 and TNF-α). We compared values of all measured parameters according to histological findings. Furthermore, we assigned AA patients into the nonperforated appendicitis group and the perforated appendicitis group. The diagnostic effects of significant markers were assessed by ROC curves. Results. Only the levels of CRP, FIB, and sB7H3 had a remarkable rising trend in AA-based groups, while differences in the levels of CRP and FIB between simple appendicitis and purulent appendicitis were not statistically significant. In addition, sB7H3 was found as the only marker in children with AA, which was markedly associated with the degree of histological findings of the appendix. Furthermore, sB7H3 had a high diagnostic value in predicting AA and complex appendicitis (PA+GA) in children. However, the diagnostic performance of sB7H3 for distinguishing PA from GA was not remarkable. Additionally, only the levels of CRP and sB7H3 were statistically different between the nonperforated appendicitis group and the perforated appendicitis group. The diagnostic performance of CRP and sB7H3 could not merely predict perforation of AA in children; however, the diagnostic performance was improved after combination. Conclusions. sB7H3 could be used as a valuable marker to predict the presence of AA and complex AA in children. However, the diagnostic value of sB7H3 to predict gangrenous/perforated appendicitis was not found to be remarkable. The combination of sB7H3 and CRP might improve the prediction of perforated appendicitis. |
| format | Article |
| id | doaj-art-36f7927494054da6b0bdcecf196d5b10 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-36f7927494054da6b0bdcecf196d5b102025-02-03T06:43:32ZengWileyJournal of Immunology Research2314-88612314-71562020-01-01202010.1155/2020/26705272670527sB7H3 in Children with Acute Appendicitis: Its Diagnostic Value and Association with Histological FindingsXiaochen Du0Yan Chen1Jie Zhu2Zhenjiang Bai3Jun Hua4Ying Li5Haitao Lv6Guangbo Zhang7Department of Emergency and Intensive Care Unit, Children’s Hospital of Soochow University, Suzhou, Jiangsu Province 215025, ChinaDepartment of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province 215006, ChinaDepartment of Pediatric Surgery, Children’s Hospital of Soochow University, Suzhou, Jiangsu Province 215025, ChinaDepartment of Emergency and Intensive Care Unit, Children’s Hospital of Soochow University, Suzhou, Jiangsu Province 215025, ChinaDepartment of Emergency and Intensive Care Unit, Children’s Hospital of Soochow University, Suzhou, Jiangsu Province 215025, ChinaDepartment of Emergency and Intensive Care Unit, Children’s Hospital of Soochow University, Suzhou, Jiangsu Province 215025, ChinaDepartment of Cardiology, Children’s Hospital of Soochow University, Suzhou, Jiangsu Province 215025, ChinaInstitute of Clinical Immunology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province 215006, ChinaBackground. Several efforts have been made to find out a valuable marker to assist the diagnosis and differentiation of gangrenous/perforated appendicitis. We aimed to determine the diagnostic capacity of soluble B7H3 (sB7H3) in acute appendicitis (AA) and its accuracy as a predictor of the severity of appendicitis. Methods. 182 children were allocated into four groups as follows: control group (CG, 90), simple appendicitis (SA, 12), purulent appendicitis (PA, 49), and gangrenous appendicitis (GA, 31). Prior to appendectomy, blood was collected and sent for analysis of routine examination and cytokines (sB7H3 and TNF-α). We compared values of all measured parameters according to histological findings. Furthermore, we assigned AA patients into the nonperforated appendicitis group and the perforated appendicitis group. The diagnostic effects of significant markers were assessed by ROC curves. Results. Only the levels of CRP, FIB, and sB7H3 had a remarkable rising trend in AA-based groups, while differences in the levels of CRP and FIB between simple appendicitis and purulent appendicitis were not statistically significant. In addition, sB7H3 was found as the only marker in children with AA, which was markedly associated with the degree of histological findings of the appendix. Furthermore, sB7H3 had a high diagnostic value in predicting AA and complex appendicitis (PA+GA) in children. However, the diagnostic performance of sB7H3 for distinguishing PA from GA was not remarkable. Additionally, only the levels of CRP and sB7H3 were statistically different between the nonperforated appendicitis group and the perforated appendicitis group. The diagnostic performance of CRP and sB7H3 could not merely predict perforation of AA in children; however, the diagnostic performance was improved after combination. Conclusions. sB7H3 could be used as a valuable marker to predict the presence of AA and complex AA in children. However, the diagnostic value of sB7H3 to predict gangrenous/perforated appendicitis was not found to be remarkable. The combination of sB7H3 and CRP might improve the prediction of perforated appendicitis.http://dx.doi.org/10.1155/2020/2670527 |
| spellingShingle | Xiaochen Du Yan Chen Jie Zhu Zhenjiang Bai Jun Hua Ying Li Haitao Lv Guangbo Zhang sB7H3 in Children with Acute Appendicitis: Its Diagnostic Value and Association with Histological Findings Journal of Immunology Research |
| title | sB7H3 in Children with Acute Appendicitis: Its Diagnostic Value and Association with Histological Findings |
| title_full | sB7H3 in Children with Acute Appendicitis: Its Diagnostic Value and Association with Histological Findings |
| title_fullStr | sB7H3 in Children with Acute Appendicitis: Its Diagnostic Value and Association with Histological Findings |
| title_full_unstemmed | sB7H3 in Children with Acute Appendicitis: Its Diagnostic Value and Association with Histological Findings |
| title_short | sB7H3 in Children with Acute Appendicitis: Its Diagnostic Value and Association with Histological Findings |
| title_sort | sb7h3 in children with acute appendicitis its diagnostic value and association with histological findings |
| url | http://dx.doi.org/10.1155/2020/2670527 |
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